南刘寄奴的化学成分研究

南刘寄奴的化学成分研究

昝珂, 陈筱清, 付强, 周思祥, 肖美添, 温晶, 屠鹏飞^*

1. 中国药科大学中药学院, 江苏南京 210009
2. 北京大学医学部天然药物及仿生药物国家重点实验室, 北京 100191
3. 华侨大学化工与制药工程系, 福建泉州 361021

收稿日期:2009-12-03 修回日期:2010-02-10 出版日期:2010-03-15 发布日期:2010-03-15
通讯作者: 屠鹏飞*

Chemical ingredients isolated from the aerial parts of Artemisia anomala

Ke Zan, Xiao-Qing Chen, Qiang Fu, Si-Xiang Zhou, Mei-Tian Xiao, Jing Wen, Peng-Fei Tu^*

1. School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210009, China
2. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China
3. Department of Chemical and Pharmaceutical Engineering, Huaqiao University, Quanzhou 362021, China

Received:2009-12-03 Revised:2010-02-10 Online:2010-03-15 Published:2010-03-15
Contact: Peng-Fei Tu*

摘要/Abstract

摘要：

从南刘寄奴中分离并鉴定了14个化合物, 分别为zhepiresinol (1), (-)-lariciresinol (2), ficusal (3), medioresinol (4), (+)-syringaresinol (5), 1β,2β-epoxy-3β,4α,10α-trihydroxyguaian-6α,12-olide (6), 5β,10α-dihydroxy-1αH-dehydroleucodin (7), 3α-chloro-8α-acetoxy-4β,10α-dihydroxy-1β,2β-epoxy-5α,7αH-guai-11(13)-en-12,6α-olide (8), 13-O-desacetyl eudesma-afraglaucolide (9), 1,10-seco-4ξ-hydroxy-muurol-5-ene-1,10-diketone (10), 1α-hydroxyafraglaucolide (11), aurantiamide (12), indole-3-aldehyde (13), loliolide (14)。所有化合物均为首次从该植物中分离得到, 其中化合物1–4, 8, 10, 13为首次从蒿属植物中分离得到。

关键词: 南刘寄奴, 奇蒿, 菊科, 化学成分, 木脂素, 倍半萜

Abstract:

Fourteen known compounds were isolated from the aerial parts of Artemisia anomala and identified as follows: zhepiresinol (1), (-)-lariciresinol (2), ficusal (3), medioresinol (4), (+)-syringaresinol (5), 1β,2β-epoxy-3β,4α,10α-trihydroxyguaian-6α,12-olide (6), 5β,10α-dihydroxy-1αH-dehydroleucodin (7), 3α-chloro-8α-acetoxy-4β,10α-dihydroxy-1β,2β-epoxy-5α,7αH-guai-11(13)-en-12,6α-olide (8), 13-O-desacetyleudesma-afraglaucolide (9), 1,10-seco-4ξ-hydroxy-muurol-5-ene-1,10-diketone (10), 1α-hydroxyafraglaucolide (11), aurantiamide (12), indole-3-aldehyde (13), loliolide (14). All these compounds were isolated from this plant for the first time and compounds 1–4, 8, 10, 13 were obtained from genus Artemisia for the first time.

Key words: Artemisia anomala, Compositae, Chemical constituents, Lignans, Sesquiterpenoids

中图分类号:

R284.2

Supporting:

Foundation item: National Natural Science Foundation of China (Grant No. 30973629).
^*Correspounding author: Tel.: 86-10-82802750

昝珂, 陈筱清, 付强, 周思祥, 肖美添, 温晶, 屠鹏飞^*

南刘寄奴的化学成分研究

[J]. .

Ke Zan, Xiao-Qing Chen, Qiang Fu, Si-Xiang Zhou, Mei-Tian Xiao, Jing Wen, Peng-Fei Tu^* . Chemical ingredients isolated from the aerial parts of Artemisia anomala [J]. .

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