Solid formulations represent the most widely used dosage forms, and their structural attributes significantly impact the efficacy of drugs. Consequently, delving into the study of solid formulation structures is of paramount importance. This paper employs bibliometrics to summarize references on solid formulations and physical structure over the past 5 years, providing a visual representation through CiteSpace. Additionally, we explore influential factors affecting the structure of solid formulations at three distinct levels: raw material, intermediate, and final product. It delves into the discussion of various characterization techniques employed to analyze the physical structure of solid formulations. The techniques include scanning electron microscopy, transmission electron microscopy, X-ray diffraction, nuclear magnetic resonance, LF-nuclear magnetic resonance, thermal analysis, and terahertz. Emphasis is placed on the significance of investigating formulation structures, serving as a found ational step for future research and development in this field. This comprehensive approach aims to contribute to the understanding and advancement of solid formulations for enhanced drug effectiveness.

This study systematically examined the dissolution behavior of furazolidone in 12 different pure solvents and in aqueous solutions containing ethylenediaminetetraacetic acid disodium salt (EDTA-2Na). The solubility data indicated that polar aprotic solvents demonstrated a marginally higher solubility of furazolidone compared to alcohols and water. Interestingly, a co-solvency effect was observed in the aqueous solutions of EDTA-2Na, where the solubility of furazolidone initially increased and then decreased with the gradual addition of EDTA-2Na, peaking at a mass fraction of 0.03 (1.949 × 10^–5 at 323.15 K). The analysis using the Kamlet-Abboud-Taft Linear Solvation Energy Relationship (KAT-LSER) model suggested that the dissolution of furazolidone in these systems was predominantly influenced by non-specific solute-solvent and solvent-solvent interactions. Furthermore, Hansen solubility parameter calculations revealed that N,N-dimethylformamide (DMF) and N,N-dimethylacetamide (DMAC) exhibited superior dissolution capabilities compared to other solvents. It was also found that the partial solubility parameters played a crucial role in determining the overall solubility behavior.

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