山蒿中木脂素和黄酮类化学成分研究

doi:10.5246/jcps.2018.06.043

中国药学(英文版)

山蒿中木脂素和黄酮类化学成分研究

张圃铭, 章宸, 曾克武, 姜勇^*, 屠鹏飞^*

北京大学医学部药学院天然药物及仿生药物国家重点实验室, 北京 100191

收稿日期:2018-05-05 修回日期:2018-05-15 出版日期:2018-06-30 发布日期:2018-06-01
通讯作者: Tel.: +86-010-82802750, E-mail: yongjiang@bjmu.edu.cn; pengfeitu@vip.163.com
基金资助:
National Natural Science Foundation of China (Grant No. 81373294) and National Key Technology R&D Program “New Drug Innovation” of China (Grant No. 2018ZX09711001-008-003).

Lignans and flavonoids from Artemisia brachyloba

Puming Zhang, Chen Zhang, Kewu Zeng, Yong Jiang^*, Pengfei Tu^*

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2018-05-05 Revised:2018-05-15 Online:2018-06-30 Published:2018-06-01
Contact: Tel.: +86-010-82802750, E-mail: yongjiang@bjmu.edu.cn; pengfeitu@vip.163.com
Supported by:
National Natural Science Foundation of China (Grant No. 81373294) and National Key Technology R&D Program “New Drug Innovation” of China (Grant No. 2018ZX09711001-008-003).

摘要/Abstract

摘要：

运用硅胶柱色谱、反相硅胶柱色谱、Sephadex LH-20柱色谱及半制备HPLC等多种分离方法对山蒿化学成分进行了研究, 分离得到13个化合物, 通过NMR数据分析, 并结合文献对比, 鉴定了化合物的结构, 其中8个木脂素和5个黄酮,均为首次从山蒿中分离得到。借助2D NMR技术首次对化合物1的波谱数据进行了全归属。对分离到的所有化合物进行了抑制脂多糖诱导的BV-2小胶质细胞NO生成实验, 化合物1, 4和10有一定的抑制NO生成活性。

关键词: 山蒿, 木脂素, 黄酮, NO

Abstract:

A phytochemical investigation on the aerial parts of Artemisia brachyloba led to the isolation of 13 compounds (1−13) for the first time, including eight lignans (1−8) and five flavonoids (9−13). The structures of the isolated compounds were elucidated by analysis of the NMR spectroscopic data and comparison with the literature.The ¹H and ¹³C NMR data of 1 were fully assigned for the first time by the 2D NMR analysis. All the isolates were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-challenged BV-2 microglial cells.

Key words: Artemisia brachyloba, Lignans, Flavonoids, NO

中图分类号:

R284

Supporting:

张圃铭, 章宸, 曾克武, 姜勇, 屠鹏飞. 山蒿中木脂素和黄酮类化学成分研究[J]. 中国药学(英文版), DOI: 10.5246/jcps.2018.06.043.

Puming Zhang, Chen Zhang, Kewu Zeng, Yong Jiang, Pengfei Tu. Lignans and flavonoids from Artemisia brachyloba[J]. Journal of Chinese Pharmaceutical Sciences, DOI: 10.5246/jcps.2018.06.043.

参考文献

[1] Editorial Committee of Flora of China, Flora of China. 2011, 20, 685.

[2] Jakupovic, J.; Eid, F.; Bohlmann, F.; El-Dahmy, S. Malabaricane derivatives from pyrethrum santolinoides. Phytochemistry. 1987, 26, 1536-1538.

[3] In, S.J.; Seo, K.H.; Song, N.Y.; Lee, D.S.; Kim, Y.C.; Baek, N.I. Lignans and neolignans from the stems of Vibrunum erosum and their neuroprotective and anti-inflammatory activity. Arch. Pharm. Res. 2015, 38, 26-34.

[4] Jia, S.H.; Liu, F.L.; Lv, F.; Chen, Y.; Dai, R. J.; Meng, W.W.; Deng, Y.L. Study on the chemical constituents of Dregea sinensis Hemsl. Nat. Prod. Res. Dev. 2013, 25, 631-633.

[5] Yu, Y.; Gao, H.; Dai, Y.; Li, X.X.; Li, J.M.; Yao, X.S. A new lignan from Gardenia jasminoides. Chin. Tradit. Herb. Drugs. 2010, 41, 509-514.

[6] Lee, D.Y.; Song, M.C.; Yoo, K.Y.; Bang, M.H.; Chung, I.S.; Kim, S.H.; Kim, D.K.; Kwon, B.M.; Jeong, T.S.; Park, M.H.; Baek, N.I. Lignans from the fruits of Cornus kousa Burg. and their cytotoxic effects on human cancer cell Lines. Arch. Pharm. Res. 2007, 30, 402-407.

[7] Wang, H.; Cong, W.L.; Fu, Z.L.; Chen, D.F.; Wang, Q. Anti-complementary constituents of Viola kunawarensis. Nat. Prod. Res. 2017, 31, 2312-2315.

[8] Duan, K.; Liu, H.; Fan, H.; Zhang, J.; Wang, Q. Synthesis and anticholinesterase inhibitory activity of Mannich base derivatives of flavonoids. J. Chem. Res. 2014, 38, 443-446.

[9] Abdellatif, Z.; Akino, J.; Bernard, B. DNA Topoisomerase I Inhibitors: Cytotoxic Flavones from Lethedon tannaensis. J. Nat. Prod. 1996, 59, 701-703.

[10] Maver, M.; Queiroz, E.F.; Wolfender, J.; Hostettmann, K. Flavonoids from the stem of Eriophorum scheuchzeri. J. Nat. Prod. 2005, 68, 1094-1098.

[11] Suleimenov, E.M.; Jose, R.A.; Rakhmadieva, S.B.; Borggraeve, W.D.; Dehaen, W. Flavonoids from Senecio viscosus. Chem. Nat. Compd. 2009, 45, 731-732.
[12] Liu, M.J.; Liu, M.C.; Gong, H.Y.; Zhao, H.J.; Yang, S. Chemical Constituents of Thalictrum ichangense. Chem. Nat. Compd. 2015, 51, 175-177.

[1]	Eric Wei Chiang Chan, Ying Ki Ng, Hung Tuck Chan, Siu Kuin Wong. An overview of flavonoids from Sophora flavescens (kushen) with some emphasis on the anticancer properties of kurarinone and sophoraflavanone G[J]. 中国药学(英文版), 2023, 32(8): 603-615.
[2]	Neha Dangi, Shikha Sharma. Cancer chemotherapy with novel bioactive natural products[J]. 中国药学(英文版), 2022, 31(8): 589-607.
[3]	Revika Rachmaniar, Dolih Gozali, Camellia Panatarani, Wahyu Priyo Legowo, Sohadi Warya, Taofik Rusdiana. Solubility enhancement of ethyl p-methoxycinnamate under nanoscale confinement[J]. 中国药学(英文版), 2022, 31(6): 461-470.
[4]	谢文军, 肖浩然, 王新童, 黄宗泽, 卞希玲, 王克威, 孙崎. 基于Sonogashira偶联反应得到的新型α7尼古丁乙酰胆碱受体正向变构调节剂[J]. 中国药学(英文版), 2022, 31(5): 374-381.
[5]	北京大学药学院天然药物及仿生药物国家重点实验室. 王晶团队利用APEX2邻近标记铜伴侣蛋白Atox1鉴定细胞核铜结合蛋白CRIP2调节自噬[J]. 中国药学(英文版), 2021, 30(9): 781-782.
[6]	北京大学药学院天然药物及仿生药物国家重点实验室. 周德敏团队在长效靶向调节性T细胞的细胞因子类药物治疗自身免疫性疾病方面取得重要进展[J]. 中国药学(英文版), 2021, 30(9): 783-784.
[7]	乔自鹏, 王奇志, 刘建福, 王明元. 胜红蓟内生真菌乙酸乙酯提取物的抗氧化及抑菌活性研究[J]. 中国药学(英文版), 2021, 30(5): 421-433.
[8]	张莹, 李聪, 刘一, 褚琳, 邹俊成, 鄢尤奇, 胡新, 凌笑梅. 基于CeZnO纳米粒子的简单灵敏的电化学阻抗免疫传感器, 用于检测载脂蛋白E4[J]. 中国药学(英文版), 2021, 30(3): 239-245.
[9]	陈佳倩, 金晨, 徐博伦, 詹煌, 付容容, 李风琴, 黄慧莲. 菝葜总黄酮主成分鉴定及苯酚胶浆诱导大鼠盆腔炎的抗炎作用评价[J]. 中国药学(英文版), 2021, 30(2): 157-168.
[10]	Ahsan Zamir Siddiqi, Muneeba Akhtar, Agha Zeeshan Mirza. Preparation and antibacterial activities of metal complexes of norfloxacin[J]. 中国药学(英文版), 2021, 30(10): 838-844.
[11]	Eric Wei Chiang Chan, Oi Yoon Michelle Soo, Yong Hui Tan, Siu Kuin Wong, Hung Tuck Chan. Nobiletin and tangeretin (citrus polymethoxyflavones): an overview on their chemistry, pharmacology and cytotoxic activities against breast cancer[J]. 中国药学(英文版), 2020, 29(7): 443-454.
[12]	北京大学药学院. 齐宪荣教授团队为脑胶质瘤精准诊疗提供新的递送策略[J]. 中国药学(英文版), 2020, 29(6): 441-442.
[13]	刘继梅, 陈明华, 陈日道, 解可波, 陈大伟, 司书毅, 戴均贵. 内生真菌Periconia sp. F-31中的三个新化合物[J]. 中国药学(英文版), 2020, 29(4): 244-251.
[14]	Thananchanoke Rattanathada, Tullayakorn Plengsuriyakarn, Rathapon Asasujarit, Anurak Cheoymang, Juntra Karbwang, Kesara Na-Bangchang. Development of oral pharmaceutical formulation of standardized crude ethanolic extract of Atractylodes lancea (Thunb) DC.[J]. 中国药学(英文版), 2020, 29(4): 280-293.
[15]	徐方方, 孙彪, 张晓琦, 刘博. 北枳椇子中的黄酮碳苷类成分[J]. 中国药学(英文版), 2020, 29(11): 813-818.

山蒿中木脂素和黄酮类化学成分研究

Lignans and flavonoids from Artemisia brachyloba

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价