An overview of flavonoids from Sophora flavescens (kushen) with some emphasis on the anticancer properties of kurarinone and sophoraflavanone G

doi:10.5246/jcps.2023.08.050

中国药学(英文版) ›› 2023, Vol. 32 ›› Issue (8): 603-615.DOI: 10.5246/jcps.2023.08.050

• 【综述】 • 下一篇

An overview of flavonoids from Sophora flavescens (kushen) with some emphasis on the anticancer properties of kurarinone and sophoraflavanone G

Eric Wei Chiang Chan¹^,^*(), Ying Ki Ng¹, Hung Tuck Chan², Siu Kuin Wong³

1. Faculty of Applied Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia
2. Secretariat of International Society for Mangrove Ecosystems (ISME), Faculty of Agriculture, University of the Ryukyus, Okinawa 903-0129, Japan
3. School of Foundation Studies, Xiamen University Malaysia, Bandar Sunsuria, 43900 Sepang, Selangor, Malaysia

收稿日期:2023-02-12 修回日期:2023-03-15 接受日期:2023-04-23 出版日期:2023-08-31 发布日期:2023-08-31
通讯作者: Eric Wei Chiang Chan
作者简介:
+ E-mail: erchan@yahoo.com

An overview of flavonoids from Sophora flavescens (kushen) with some emphasis on the anticancer properties of kurarinone and sophoraflavanone G

Eric Wei Chiang Chan¹^,^*(), Ying Ki Ng¹, Hung Tuck Chan², Siu Kuin Wong³

1 Faculty of Applied Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia
2 Secretariat of International Society for Mangrove Ecosystems (ISME), Faculty of Agriculture, University of the Ryukyus, Okinawa 903-0129, Japan
3 School of Foundation Studies, Xiamen University Malaysia, Bandar Sunsuria, 43900 Sepang, Selangor, Malaysia

Received:2023-02-12 Revised:2023-03-15 Accepted:2023-04-23 Online:2023-08-31 Published:2023-08-31
Contact: Eric Wei Chiang Chan

About author:

Dr Eric Wei Chiang CHAN is Associate Professor at the Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia. Dr Eric Chan has 10 publications in JCPS with 91 papers, 2597 citations and 24 h-index in Scopus. Dr Chan’s publications were ranked top 2% in the world (Pharmacology and Pharmacy) from 2020−2022 by University of Stanford.

Dr Siu Kuin WONG is Lecturer at the School of Foundation Studies, Xiamen University Malaysia, Sepang, Selangor. Dr Wong has 10 papers in JCPS with 44 papers, 1558 citations and 17 h-index in Scopus.

摘要/Abstract

摘要：

In this overview, the current knowledge of the constituents of flavonoids isolated from the roots of Sophora flavescens (kushen) is updated. Flavonoids consist of several classes, such as flavanones, flavonols, chalcones, isoflavones, biflavonoids, flavanols, and flavones. The most common compounds are kurarinone (KRN), sophoraflavanone G (SFG), 2?-methoxykurarinone, kuraridine, isoxanthohumol, and formononetin. KRN and SFG are two major flavanones with more vital anticancer properties than other flavonoids. From the literature, the cytotoxic values of KRN and SFG are variable and depend on the type of cancer cells tested. The anticancer activities of these two flavonoids involve different molecular mechanisms. Clinical trials are needed before anticancer drugs from KRN and SFG can be developed.

关键词: Kushen, Flavanones, Cytotoxicity, Molecular mechanisms

Abstract:

Key words: Kushen, Flavanones, Cytotoxicity, Molecular mechanisms

Supporting:

Eric Wei Chiang Chan, Ying Ki Ng, Hung Tuck Chan, Siu Kuin Wong. An overview of flavonoids from Sophora flavescens (kushen) with some emphasis on the anticancer properties of kurarinone and sophoraflavanone G[J]. 中国药学(英文版), 2023, 32(8): 603-615.

图/表 5

Figure 1. Sophora flavescens flowers (left), slices of dried roots (middle), and fruits (right).

Table 1. Flavonoids isolated from the roots of Sophora flavescens (kushen).

Figure 2. Chemical structures of sophoflavescenol (a), kuraridin (b), genistein (c), luteolin (d), sophobiflavonoid E (e), and kushenol H (f), representing flavonols, chalcones, isoflavones, flavones, biflavonoids, and flavanols in the roots of Sophora flavescens, respectively.

Figure 3. The chemical structures of KRN (left) and SFG (right), showing the highlighted lavandulyl moiety at C8, and the encircled naringenin moiety of rings A?C.

Table 2. Anticancer activities of KRN, SFG, and other flavonoids.

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An overview of flavonoids from Sophora flavescens (kushen) with some emphasis on the anticancer properties of kurarinone and sophoraflavanone G

An overview of flavonoids from Sophora flavescens (kushen) with some emphasis on the anticancer properties of kurarinone and sophoraflavanone G

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