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中国药学(英文版) ›› 2023, Vol. 32 ›› Issue (8): 603-615.DOI: 10.5246/jcps.2023.08.050

• 【综 述】 •    下一篇

An overview of flavonoids from Sophora flavescens (kushen) with some emphasis on the anticancer properties of kurarinone and sophoraflavanone G

Eric Wei Chiang Chan1,*(), Ying Ki Ng1, Hung Tuck Chan2, Siu Kuin Wong3   

  1. 1. Faculty of Applied Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia
    2. Secretariat of International Society for Mangrove Ecosystems (ISME), Faculty of Agriculture, University of the Ryukyus, Okinawa 903-0129, Japan
    3. School of Foundation Studies, Xiamen University Malaysia, Bandar Sunsuria, 43900 Sepang, Selangor, Malaysia
  • 收稿日期:2023-02-12 修回日期:2023-03-15 接受日期:2023-04-23 出版日期:2023-08-31 发布日期:2023-08-31
  • 通讯作者: Eric Wei Chiang Chan
  • 作者简介:

An overview of flavonoids from Sophora flavescens (kushen) with some emphasis on the anticancer properties of kurarinone and sophoraflavanone G

Eric Wei Chiang Chan1,*(), Ying Ki Ng1, Hung Tuck Chan2, Siu Kuin Wong3   

  1. 1 Faculty of Applied Sciences, UCSI University, 56000 Cheras, Kuala Lumpur, Malaysia
    2 Secretariat of International Society for Mangrove Ecosystems (ISME), Faculty of Agriculture, University of the Ryukyus, Okinawa 903-0129, Japan
    3 School of Foundation Studies, Xiamen University Malaysia, Bandar Sunsuria, 43900 Sepang, Selangor, Malaysia
  • Received:2023-02-12 Revised:2023-03-15 Accepted:2023-04-23 Online:2023-08-31 Published:2023-08-31
  • Contact: Eric Wei Chiang Chan
  • About author:
    Dr Eric Wei Chiang CHAN is Associate Professor at the Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Malaysia. Dr Eric Chan has 10 publications in JCPS with 91 papers, 2597 citations and 24 h-index in Scopus. Dr Chan’s publications were ranked top 2% in the world (Pharmacology and Pharmacy) from 2020−2022 by University of Stanford.
    Dr Siu Kuin WONG is Lecturer at the School of Foundation Studies, Xiamen University Malaysia, Sepang, Selangor. Dr Wong has 10 papers in JCPS with 44 papers, 1558 citations and 17 h-index in Scopus.

摘要:

In this overview, the current knowledge of the constituents of flavonoids isolated from the roots of Sophora flavescens (kushen) is updated. Flavonoids consist of several classes, such as flavanones, flavonols, chalcones, isoflavones, biflavonoids, flavanols, and flavones. The most common compounds are kurarinone (KRN), sophoraflavanone G (SFG), 2?-methoxykurarinone, kuraridine, isoxanthohumol, and formononetin. KRN and SFG are two major flavanones with more vital anticancer properties than other flavonoids. From the literature, the cytotoxic values of KRN and SFG are variable and depend on the type of cancer cells tested. The anticancer activities of these two flavonoids involve different molecular mechanisms. Clinical trials are needed before anticancer drugs from KRN and SFG can be developed.

关键词: Kushen, Flavanones, Cytotoxicity, Molecular mechanisms

Abstract:

In this overview, the current knowledge of the constituents of flavonoids isolated from the roots of Sophora flavescens (kushen) is updated. Flavonoids consist of several classes, such as flavanones, flavonols, chalcones, isoflavones, biflavonoids, flavanols, and flavones. The most common compounds are kurarinone (KRN), sophoraflavanone G (SFG), 2?-methoxykurarinone, kuraridine, isoxanthohumol, and formononetin. KRN and SFG are two major flavanones with more vital anticancer properties than other flavonoids. From the literature, the cytotoxic values of KRN and SFG are variable and depend on the type of cancer cells tested. The anticancer activities of these two flavonoids involve different molecular mechanisms. Clinical trials are needed before anticancer drugs from KRN and SFG can be developed.

Key words: Kushen, Flavanones, Cytotoxicity, Molecular mechanisms

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