Solubility enhancement of ethyl p-methoxycinnamate under nanoscale confinement

doi:10.5246/jcps.2022.06.040

中国药学(英文版) ›› 2022, Vol. 31 ›› Issue (6): 461-470.DOI: 10.5246/jcps.2022.06.040

Solubility enhancement of ethyl p-methoxycinnamate under nanoscale confinement

Revika Rachmaniar¹^,²^,⁴^,⁵, Dolih Gozali¹^,², Camellia Panatarani³^,⁴, Wahyu Priyo Legowo⁵, Sohadi Warya⁵, Taofik Rusdiana¹^,²^,^*()

1. Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Jatinangor 45363, West Java, Indonesia
2. Pharmaceutical Development Study Centre, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Jatinangor 45363, West Java, Indonesia
3. Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Jatinangor 45363, West Java, Indonesia
4. Functional Nano Powder, University Center of Excellence, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Jatinangor 45363, West Java, Indonesia
5. Department of Pharmaceutics, Indonesian School of Pharmacy, Jl. Soekarno-Hatta No. 354, Bandung 40266, West Java, Indonesia

收稿日期:2022-01-13 修回日期:2022-02-14 接受日期:2022-03-11 出版日期:2022-06-30 发布日期:2022-06-30
通讯作者: Taofik Rusdiana
作者简介:
+ Tel.: +62 812-2227-8287, E-mail: t.rusdiana@unpad.ac.id
基金资助:
The authors gratefully acknowledge the financial support of the Ministry of Education and Culture for funding this research through the Research and Technology Grant Program/National Research and Innovation Agency Number: 1827/UN6.3.1/LT/2020.

Solubility enhancement of ethyl p-methoxycinnamate under nanoscale confinement

Revika Rachmaniar¹^,²^,⁴^,⁵, Dolih Gozali¹^,², Camellia Panatarani³^,⁴, Wahyu Priyo Legowo⁵, Sohadi Warya⁵, Taofik Rusdiana¹^,²^,^*()

1 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Jatinangor 45363, West Java, Indonesia
2 Pharmaceutical Development Study Centre, Faculty of Pharmacy, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Jatinangor 45363, West Java, Indonesia
3 Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Jatinangor 45363, West Java, Indonesia
4 Functional Nano Powder, University Center of Excellence, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang KM 21, Jatinangor 45363, West Java, Indonesia
5 Department of Pharmaceutics, Indonesian School of Pharmacy, Jl. Soekarno-Hatta No. 354, Bandung 40266, West Java, Indonesia

Received:2022-01-13 Revised:2022-02-14 Accepted:2022-03-11 Online:2022-06-30 Published:2022-06-30
Contact: Taofik Rusdiana

摘要/Abstract

摘要：

The low solubility of ethyl p-methoxycinnamate (EPMC) inhibits its absorption in the gastrointestinal tract, impairing its pharmacological effect. The solubility of EPMC can be increased by utilizing a carrier in the type of mesoporous silica nanoparticles (MSN). In the present study, we aimed to confine EPMC under the nanoscale of MSN (MSN-EPMC) to increase the water solubility of EPMC. MSN was prepared using sodium silica as a precursor and Tween 80 and Span 80 as templates. Briefly, 500 mg MSN was dispersed into 2% w/v EPMC solution, stirred at 100 r/min for 24 h, and dried at 60 °C. The results showed that the MSN formed had a particle size of 87.1305 nm, a surface area of 68.86 m²/g, a pore diameter of 20.45 nm, and a pore volume of 0.352 cm³/g. EPMC was successfully confined under the nanoscale of MSN. MSN-EPMC had an amorphous structure, a loading capacity of 10.6%, and a loading efficiency of 18.18%. The solubility of MSN-EPMC was increased by 2.63 folds at 30 min compared with EPMC. The amorphous structure of MSN-EPMC was responsible for the enhancement of the water solubility. It could be concluded that the confining of EPMC in MSN had the potential to increase the solubility of a water-soluble isolate of a plant.

关键词: Solubility, Ethyl p-methoxycinnamate, Mesoporous silica nanoparticles

Abstract:

Key words: Solubility, Ethyl p-methoxycinnamate, Mesoporous silica nanoparticles

Supporting:

Revika Rachmaniar, Dolih Gozali, Camellia Panatarani, Wahyu Priyo Legowo, Sohadi Warya, Taofik Rusdiana. Solubility enhancement of ethyl p-methoxycinnamate under nanoscale confinement[J]. 中国药学(英文版), 2022, 31(6): 461-470.

图/表 6

Figure 1. Internal morphology of MSN. Figure B (scale bar 20 nm) is an enlargement of Figure A (scale bar 50 nm).

Figure 2. EPMC loading into MSN process.

Figure 3. The infrared spectrum of EPMC, MSN, and MSN-EPMC.

Figure 4. Difractogram of EPMC, MSN, and MSN-EPMC.

Figure 5. Solubility graphic of EPMC and MSN-EPMC.

Figure 6. Simulation of (A) EPMC and (B) MSN-EPMC solubility process.

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Solubility enhancement of ethyl p-methoxycinnamate under nanoscale confinement

Solubility enhancement of ethyl p-methoxycinnamate under nanoscale confinement

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