Preparation and antibacterial activities of metal complexes of norfloxacin

doi:10.5246/jcps.2021.10.072

中国药学(英文版) ›› 2021, Vol. 30 ›› Issue (10): 838-844.DOI: 10.5246/jcps.2021.10.072

Preparation and antibacterial activities of metal complexes of norfloxacin

Ahsan Zamir Siddiqi¹^,², Muneeba Akhtar³, Agha Zeeshan Mirza⁴^,^*()

1. Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan
2. Highnoon Laboratories Limited, Lahore, Pakistan
3. Department of Pharmaceutics, Faculty of Pharmacy, University of Central Punjab, Lahore-54782, Pakistan
4. Chemistry Department, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia

收稿日期:2021-04-12 修回日期:2021-06-17 接受日期:2021-07-11 出版日期:2021-10-24 发布日期:2021-10-24
通讯作者: Agha Zeeshan Mirza
作者简介:
+ E-mail: dr.zeeshan80@gmail.com

Preparation and antibacterial activities of metal complexes of norfloxacin

Ahsan Zamir Siddiqi¹^,², Muneeba Akhtar³, Agha Zeeshan Mirza⁴^,^*()

1 Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan
2 Highnoon Laboratories Limited, Lahore, Pakistan
3 Department of Pharmaceutics, Faculty of Pharmacy, University of Central Punjab, Lahore-54782, Pakistan
4 Chemistry Department, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia

Received:2021-04-12 Revised:2021-06-17 Accepted:2021-07-11 Online:2021-10-24 Published:2021-10-24
Contact: Agha Zeeshan Mirza

摘要/Abstract

摘要：

The metal complexes of norfloxacin were prepared, and their structures were characterized using spectroscopic techniques like IR, ¹H NMR, UV, atomic absorption, and CHN analysis. The solubility, melting point, and conductance measurements were also performed. These studies suggested that norfloxacin formed complexes with the metals utilizing carbonyl oxygen atom of the ring and carboxylic group oxygen atom. The antibacterial activities of these metal complexes against 14 different Gram-positive and Gram-negative microorganisms were studied by the disk susceptibility method. It was observed that the complexes of norfloxacin with magnesium, calcium, cobalt, nickel, and copper showed improved activity compared with the stated drug.

关键词: Norfloxacin, Metal complexes, Characterization, Antibacterial activities

Abstract:

Key words: Norfloxacin, Metal complexes, Characterization, Antibacterial activities

Supporting:

Ahsan Zamir Siddiqi, Muneeba Akhtar, Agha Zeeshan Mirza. Preparation and antibacterial activities of metal complexes of norfloxacin[J]. 中国药学(英文版), 2021, 30(10): 838-844.

Ahsan Zamir Siddiqi, Muneeba Akhtar, Agha Zeeshan Mirza. Preparation and antibacterial activities of metal complexes of norfloxacin[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(10): 838-844.

图/表 7

Figure 1. Structure of norfloxacin.

Table 1. Physical characteristics of norfloxacin metal complex.

Table 2. Proton NMR assignments of norfloxacin and its metal complexes.

Figure 2. Proposed structure of?norfloxacin?metal complex.

Table 3. Elemental analysis of norfloxacin and its metal complexes.

Table 4. Zone of inhibition (mm) of norfloxacin and its metal complexes.

Table 5. Zone of inhibition (mm) of norfloxacin and its metal complexes.

参考文献 18

[1]	Vincent, T.A. The Quinolones, Academic Press. 1998, 2^nd edition, 89, 31.
[2]	Siddiqui, F.A.; Arayne, M.S.; Sultana, N.; Mirza, A.Z.; Zuberi, M.H.; Qureshi, F. Med. Chem. Res. 2010, 19, 1259.
[3]	Scott, L.D. Antibacterial Chemotherapeutic Agents, Blackie Academic and Professional, 1997, 298.
[4]	Neu, H.C.; Labthavikul, P. Antimicrob. Agents Chemother. 1982, 22, 23.
[5]	Chen, L.; Hu, Y. Chin. J. Magn. Resonance. 1987, 4, 155.
[6]	Gao, F.; Yang, P.; Xie, J.; Wang, H. J. Inorg. Biochem. 1995, 60, 61.
[7]	Campbell, N.R.C.; Kara, M.; Hasinoff, B.B. Br. J. Clin. Pharmacol. 1992, 33, 115.
[8]	Shiba, K.; Sakamoto, M.; Nakazawa, Y.; Sakai, O. Drugs. 1995, 49, 360.
[9]	Siddiqui, F.A.; Arayne, M.S.; Sultana, N.; Qureshi, F.; Mirza, A.Z.; Shehnaz, H. Chem. Anal. (Warsaw). 2009, 54, 1465.
[10]	Anamika, D.; Firasat, H.; Dhanraj, T.M. Bioinorganic Chem. Applications. Article. 2014, ID 457478, 1.
[11]	Sultana, N.; Araye, M.S.; Siddiqi, A.Z.; Mirza, A.Z. Synthesis and antibacterial studies of ciprofloxacin-metal complexes. J. Chin. Pharm. Sci. 2019, 28, 422–429.
[12]	Arayne, M.S.; Sultana, N.; Mirza, A.Z. J. Mol. Struct. 2009, 927, 54–59.
[13]	Bauer, A.W.; Kirby, W.M.M.; Sherris, J.C.; Turck, M. Am. J. Clin. Pathol. 1966, 45, 493.
[14]	Freddo, R.J.; Dalla, C.T. J. Pharm. Sci. 2002, 91, 2433.
[15]	Jamil, A.M. Acta Chim. Solv. 2002, 49, 457.
[16]	Marija, Z.; Iztok, T.; Peter, B.; Andrew, J.P.W.; David, J.W. Croat. Chem. Acta. 2001, 74, 61.
[17]	Marija, Z.; Iztok, A.; Peter ,B.; Alojz, K. Croat. Chem. Acta. 2002, 75, 1.
[18]	Victor, L.M.D. Antibiotics in Laboratory Medicine. Williams and Wilkins, 1991, 3^rd edition, 17.

Preparation and antibacterial activities of metal complexes of norfloxacin

Preparation and antibacterial activities of metal complexes of norfloxacin

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

图/表 7

参考文献 18

相关文章 1

编辑推荐

Metrics

本文评价