长梗米蒿中倍半萜类化学成分研究

doi:10.5246/jcps.2018.08.058

中国药学(英文版) ›› 2018, Vol. 27 ›› Issue (8): 576-581.DOI: 10.5246/jcps.2018.08.058

长梗米蒿中倍半萜类化学成分研究

薛杨¹, 章宸¹, 武志博², 张圃铭¹, 赵明波¹, 姜勇^1*, 屠鹏飞^1*

1. 北京大学医学部药学院天然药物及仿生药物国家重点实验室, 北京 100191
2. 阿拉善盟林业治沙研究所, 内蒙古阿拉善盟 750306

收稿日期:2018-05-22 修回日期:2018-07-08 出版日期:2018-09-04 发布日期:2018-07-15
通讯作者: Tel.: +86-010-82802719; +86-010-82802750, E-mail: yongjiang@bjmu.edu.cn; pengfeitu@vip.163.com
基金资助:
National Natural Science Foundation of China (NSFC, Grant No. 81373294) and National Key Technology R&D Program “New Drug Innovation” of China (Grant No. 2018ZX09711001-008-003).

Sesquiterpenes from Artemisia giraldii var. longipedunculata

Yang Xue¹, Chen Zhang¹, Zhibo Wu², Puming Zhang¹, Mingbo Zhao¹, Yong Jiang^1*, Pengfei Tu^1*

1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
2. Alashan League Institute of Forestry Sand Control, Alashan 750306, China

Received:2018-05-22 Revised:2018-07-08 Online:2018-09-04 Published:2018-07-15
Contact: Tel.: +86-010-82802719; +86-010-82802750, E-mail: yongjiang@bjmu.edu.cn; pengfeitu@vip.163.com
Supported by:
National Natural Science Foundation of China (NSFC, Grant No. 81373294) and National Key Technology R&D Program “New Drug Innovation” of China (Grant No. 2018ZX09711001-008-003).

摘要/Abstract

摘要：

本研究运用硅胶、C₁₈反相、MCI柱色谱及半制备HPLC等多种色谱分离方法从长梗米蒿中分离得到10个倍半萜。通过NMR和MS数据分析, 并结合文献数据对比旋光等方法, 鉴定了它们的结构, 包括12-hydroxy-α-cyperone (1), 1β,6α-dihydroxyeudesma-4(15)-ene (2), carainterol A (3), oplodiol (4), douglanin (5), 1α-hydroxyisodauc-4-en-15-al (6), 3α,6α-dihydroxybisabola-4,10-diene (7), 4α,5β-dihydroxybisabola-2,10-diene (8), opposit-4(15)-ene-1β,7-diol (9)和saniculamoid D (10)。所有化合物均为首次从该植物中分离得到, 其中5个化合物为首次从本属植物中分离得到。另外基于2D NMR对化合物1的碳谱数据进行了首次全归属。

关键词: 长梗米蒿, 倍半萜类成分, 桉叶烷

Abstract:

A phytochemical investigation on the aerial parts of Artemisia giraldii var. longipedunculata led to the isolation of 10 known sesquiterpenes, including12-hydroxy-α-cyperone (1), 1β,6α-dihydroxyeudesma-4(15)-ene (2), carainterol A (3), oplodiol (4),douglanin (5), 1α-hydroxyisodauc-4-en-15-al (6), 3α,6α-dihydroxybisabola-4,10-diene (7), 4α,5β-dihydroxybisabola-2,10-diene(8), opposit-4(15)-ene-1β,7-diol (9), and saniculamoid D (10), respectively. Their structures were elucidated by analysis of the MS and NMR spectroscopic data and comparison with the literature. All the isolates were obtained from A. giraldii var. longipedunculata for the first time, and five of them were obtained from the genus Artemisia for the first time. Additionally, the ¹³C NMR data of 1 were fully assigned based on the 2D NMR data for the first time.

Key words: Artemisia giraldii var. longipedunculata, Sesquiterpene, Eudesmane

中图分类号:

R284

Supporting:

薛杨, 章宸, 武志博, 张圃铭, 赵明波, 姜勇, 屠鹏飞. 长梗米蒿中倍半萜类化学成分研究[J]. 中国药学(英文版), 2018, 27(8): 576-581.

Yang Xue, Chen Zhang, Zhibo Wu, Puming Zhang, Mingbo Zhao, Yong Jiang, Pengfei Tu. Sesquiterpenes from Artemisia giraldii var. longipedunculata[J]. Journal of Chinese Pharmaceutical Sciences, 2018, 27(8): 576-581.

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长梗米蒿中倍半萜类化学成分研究

Sesquiterpenes from Artemisia giraldii var. longipedunculata

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