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中国药学(英文版)

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毛莲蒿中倍半萜类化学成分研究

田帅华, 魏荷琳, 赵明波, 章宸, 屠鹏飞*   

  1. 北京大学医学部 药学院 天然药物及仿生药物国家重点实验室, 北京 100191
  • 收稿日期:2013-03-30 修回日期:2013-04-15 出版日期:2013-11-15 发布日期:2014-01-22
  • 通讯作者: 屠鹏飞*

Sesquiterpenes from the aerial parts of Artemisia vestita Wall.

Shuaihua Tian, Helin Wei, Mingbo Zhao, Chen Zhang, Pengfei Tu*   

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
  • Received:2013-03-30 Revised:2013-04-15 Online:2013-11-15 Published:2014-01-22
  • Contact: Pengfei Tu*

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摘要：

研究蒿属植物毛莲蒿地上部分倍半萜类化学成分, 通过硅胶柱色谱、反相硅胶柱色谱、制备高效液相色谱等色谱方法分离得到12个倍半萜类成分, 经多种波谱方法鉴定其结构, 分别为negunfurol (1), schensianol A (2), artemine (3), eudesm-4(14)-en-12-oic acid, erivanin (4), 1,5-diepi-artemin (5), acetylartemin (6), naphtho[1,2-b]furan-2(3H)-one,6-(acetyloxy)-decahydro-9a-hydroxy-3,5a-dimethyl-9-methylene-(3S,3aS,5aS,6S,9aS,9bS) (7), naphtho[1,2-b]furan-2(3H)-one,6-(acetyloxy)-3a,4,5,5a,6,7,8,9b-octahydro-8-hydroxy-3,5a,9-trimethyl-(3S,3aS,5aR,6S,8S,9bS) (8), isoerivanin (9), barrelierin (10), (11S)-1-oxoeudesm-4(14)-eno-13,6α-lactone (11), 1-epi-dehydroisoeranin (12)。其中化合物1和2为首次从蒿属植物中分离得到, 其它化合物均为首次从毛莲蒿中分离得到。

关键词: 毛莲蒿, 倍半萜内酯, 桉叶烷, 呋喃型倍半萜, 化学成分

Abstract:

A chemical investigation of the aerial parts of Artemisia vestita Wall. led to the isolation of 12 known sesquiterpenes, including 2 furan-containing sesquiterpenoids and 10 eudesmane sesquiterpene lactones. Their structures were identified as negunfurol (1), schensianol A (2), artemine (3), erivanin (4), 1,5-diepi-artemin (5), acetylartemin (6), naphtho[1,2-b]furan-2(3H)-one, 6-(acetyloxy)decahydro-9a-hydroxy-3,5a-dimethyl-9-methylene-(3S,3aS,5aS,6S,9aS,9bS) (7), naphtho[1,2-b]furan-2(3H)-one, 6-(acetyloxy)-3a,4,5,5a,6,7,8,9b-octahydro-8-hydroxy-3,5a,9-trimethyl- (3S,3aS,5aR,6S,8S,9bS) (8), isoerivanin (9), barrelierin (10), (11S)-1-oxoeudesm-4(14)-eno-13,6α-lactone (11), 1-epi-dehydroisoeranin (12), respectively. All of these compounds were isolated from Artemisia vestita for the first time, and compounds 1 and 2 were isolated from the genus Artemisia for the first time.

Key words: Artemisia vestita, Sesquiterpene lactones, Eudesmane, Furan-containing sesquiterpenoid, Chemical constituents

中图分类号: 

Supporting:

Foundation items: National Natural Science Foundation of China (Grant No. 30973629) and National Key Technology R&D Program “New Drug Innovation” of China (Grant No. 2012ZX09301002-002-002, 2012ZX09304-005). #br# *Corresponding author. Tel.: 86-10-82802750

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