蛇婆子地上部分化学成分研究

doi:10.5246/jcps.2019.07.045

中国药学(英文版) ›› 2019, Vol. 28 ›› Issue (7): 468-475.DOI: 10.5246/jcps.2019.07.045

蛇婆子地上部分化学成分研究

花一鸣, 张晓雯, 曾克武, 张庆英, 屠鹏飞^*

北京大学医学部药学院天然药物及仿生药物国家重点实验室, 北京 100191

收稿日期:2019-04-17 修回日期:2019-05-23 出版日期:2019-07-31 发布日期:2019-05-29
通讯作者: Tel.: +86-010-82802750, E-mail: pengfeitu@vip.163.com
基金资助:
National Natural Science Foundation of China (Grant No. 81473106 and 81773864), and The Drug Innovation Major Project of China (Grant No. 2018ZX09711001-008-003).

Chemical constituents from the aerial parts of Waltheria indica Linn.

Yiming Hua, Xiaowen Zhang, Kewu Zeng, Qingying Zhang, Pengfei Tu^*

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2019-04-17 Revised:2019-05-23 Online:2019-07-31 Published:2019-05-29
Contact: Tel.: +86-010-82802750, E-mail: pengfeitu@vip.163.com
Supported by:
National Natural Science Foundation of China (Grant No. 81473106 and 81773864), and The Drug Innovation Major Project of China (Grant No. 2018ZX09711001-008-003).

摘要/Abstract

摘要：

运用多种色谱和波谱方法对蛇婆子地上部分的化学成分进行研究, 从中分离鉴定了16个化合物, 包括5个萜类(1–5), 4个香豆素(6–9), 6个黄酮(10–15)和1个其它类化合物(16)。除了化合物12和15外, 其余14个化合物均为首次从蛇婆子中分离得到, 其中香豆素类化合物为首次报道从蛇婆子中分离得到。对分离得到的16个化合物进行了体外NO生成抑制活性筛选, 结果显示化合物10, 13和14有弱的NO生成抑制活性。

关键词: 蛇婆子, 萜, 黄酮, 香豆素, NO生成抑制活性

Abstract:

A phytochemical investigation on the aerial parts of Waltheria indica Linn. led to the isolation of 16 compounds,including five terpenoids (1–5), four coumarins (6–9), six flavonoids (10–15), and one phenylpropanoid glycoside (16). The structuresof these compounds were identified by spectroscopic data analysis and comparison with those reported in the literatures. Except for12 and 15, all the compounds were isolated from W. indica for the first time. Moreover, coumarins were firstly reported to be obtained from this herb. The NO production inhibitory activities of all the isolated compounds in LPS-induced BV-2 cells were also presented.

Key words: Waltheria indica, Terpenoids, Flavonoids, Coumarins, NO production inhibitory activities

中图分类号:

R284

Supporting:

花一鸣, 张晓雯, 曾克武, 张庆英, 屠鹏飞. 蛇婆子地上部分化学成分研究[J]. 中国药学(英文版), 2019, 28(7): 468-475.

Yiming Hua, Xiaowen Zhang, Kewu Zeng, Qingying Zhang, Pengfei Tu. Chemical constituents from the aerial parts of Waltheria indica Linn.[J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(7): 468-475.

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蛇婆子地上部分化学成分研究

Chemical constituents from the aerial parts of Waltheria indica Linn.

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