内源性抗氧化蛋白DJ-1: 弱精症治疗的潜在靶点

doi:10.5246/jcps.2017.10.079

中国药学(英文版) ›› 2017, Vol. 26 ›› Issue (10): 697-708.DOI: 10.5246/jcps.2017.10.079

• 【综述】 • 下一篇

内源性抗氧化蛋白DJ-1: 弱精症治疗的潜在靶点

王玉鹏, 孙懿^*, 蒲小平^*

北京大学医学部药学院天然药物及仿生药物国家重点实验室; 分子与细胞药理学系, 北京 100191

收稿日期:2017-08-26 修回日期:2017-09-20 出版日期:2017-10-31 发布日期:2017-09-27
通讯作者: Tel.: +86-010-82802648; +86-010-82802431, E-mail: sunyi@bjmu.edu.cn; pxp123@bjmu.edu.cn
作者简介:蒲小平, 教授, 女, 1990–1995年, 留学日本北海道大学药学部, 获得硕士、博士学位。1995–1997年, 在军事医学科学院基础所从事博士后研究。1997至今, 在北京大学药学院分子与细胞药理学系工作。2002年7月任教授, 2005年1月任博士生导师。在国内外学术刊物上发表科研论文100余篇。其中, 国外SCI论文60余篇, 授权中国专利6项。2005年获教育部提名国家科学技术奖自然科学一等奖一项。主持完成或正在实施多项科研基金。此外负责完成企业多项西药或中药新药临床前药理及毒理研究。主编或参编8本专著或译著。研究方向包括药物对帕金森病相关蛋白和基因的调节作用, 中药对肝纤维化预防和治疗作用研究, 以及吗啡或新型毒品依赖动物血清蛋白质组学研究。
基金资助:
National Natural Science Foundation of China (Grant No. 81401259, U1603128).

Endogenous antioxidant DJ-1: A potential target for asthenozoospermia

Yupeng Wang, Yi Sun^*, Xiaoping Pu^*

State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2017-08-26 Revised:2017-09-20 Online:2017-10-31 Published:2017-09-27
Contact: Tel.: +86-010-82802648; +86-010-82802431, E-mail: sunyi@bjmu.edu.cn; pxp123@bjmu.edu.cn
About author:During 1990–1995, Dr. Pu obtained her M.Sc. and Ph.D. degree in Faculty of Pharmaceutical Sciences, Hokkaido University. In the period of 1995–1997, she did postdoctoral research at Institute of Basic Medical Sciences, Academy of Military Medical Sciences, China. During 1997–2002, she joined the department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences at Peking University as an Associate Professor. In 2002, Dr. Pu joined as a professor at School of Pharmaceutical Sciences in Peking University. She has published more than 100 articles in domestic and international journals, including about 60 SCI articles. She has also obtained 6 patents in China. Dr. Pu was granted the First-Class Natural Science Award (ranked No. 2) of the State Science and Technology Award by Ministry of Education of the People’s Republic of China. She has also directed several pre-clinical pharmacological and toxicological studies of new drugs. Dr. Pu has also authored 8 original or translated books including Manual of Protein Techniques, Innovative Pharmaceutical Chemistry, and Laboratory Guide in Experimental Pharmacology. Her main research interest is including Drug regulation of Parkinson’s disease genes and proteins, protective and therapeutic effects of TCM on experimental hepatic fibrosis and proteomic study on blood serum in morphine or New-type Drugs dependent animals.
Supported by:
National Natural Science Foundation of China (Grant No. 81401259, U1603128).

摘要/Abstract

摘要：

弱精症是一种常见的男性不育疾病, 表现为精子前向运动能力的减退, 其病因尚不明确。DJ-1蛋白广泛存在于肝脏、骨骼肌、肾脏、大脑和睾丸, 与包括男性不育症在内的许多疾病相关。本文旨在说明DJ-1对精子的内源性抗氧化作用与弱精症有关, DJ-1的抗氧化作用可能成为弱精症治疗的潜在靶点。

关键词: 弱精症, DJ-1, 氧化应激, 线粒体

Abstract:

Asthenozoospermia is a common cause of male infertility and is characterized by reduced forward motility of spermatozoa. The pathogenesis of asthenozoospermia remains unclear. DJ-1 is a ubiquitous protein, widely expressed in the liver, skeletal muscle, kidney, brain and testis. It has been found correlated with many diseases including male infertility. This review presents the novel concept that the endogenous antioxidant properties of DJ-1 in sperm is associated with asthenozoospermia. Thus, DJ-1 is likely a new target for the treatment of asthenozoospermia.

Key words: Asthenozoospermia, DJ-1, Oxidative stress, Mitochondria

中图分类号:

R969

Supporting:

王玉鹏, 孙懿, 蒲小平. 内源性抗氧化蛋白DJ-1: 弱精症治疗的潜在靶点[J]. 中国药学(英文版), 2017, 26(10): 697-708.

Yupeng Wang, Yi Sun, Xiaoping Pu. Endogenous antioxidant DJ-1: A potential target for asthenozoospermia[J]. Journal of Chinese Pharmaceutical Sciences, 2017, 26(10): 697-708.

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内源性抗氧化蛋白DJ-1: 弱精症治疗的潜在靶点

Endogenous antioxidant DJ-1: A potential target for asthenozoospermia

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