胃癌抗氧化治疗的研究进展

doi:10.5246/jcps.2016.06.052

中国药学(英文版) ›› 2016, Vol. 25 ›› Issue (6): 466-476.DOI: 10.5246/jcps.2016.06.052

• 【短篇综述】 • 上一篇

胃癌抗氧化治疗的研究进展

于丽娜, 高彩霞, 马俊, 郝雯瑾, 郑秋生^*

滨州医学院, 山东烟台 264000

收稿日期:2015-12-17 修回日期:2016-02-22 出版日期:2016-06-29 发布日期:2016-04-07
通讯作者: Tel.: +86-13963871815, E-mail: zqsyr@sohu.com
作者简介:郑秋生教授, 博士生导师, 教育部新世纪优秀人才, 医药领域国家科技重大专项“十二五”计划技术管理候选专家, 新疆特种植物药资源教育部重点实验室主任, 西北天然药物(中藏药)产业技术创新战略联盟专家技术委员会委员, 国家“863”计划专家库成员, 国家学位和研究生教育专家组成员, 兰州大学、中国海洋大学兼职教授, 石河子大学“绿洲学者”特聘教授, 药理学省级重点学科学术带头人。曾主持科技部重大新药创制科技专项、国家科技支撑计划、 “973”前期项目、国家自然科学基金等重大研究项目20余项; 先后参与十多个新药开发项目评价研究工作, 申请相关专利十余项。在国内外学术期刊发表论文160余篇, 其中SCI与EI收录论文近100篇, 出版专著5部, 获得省部级科技进步一等奖2项, 二等奖5项, 三等奖1项。现为Journal of Chemistry客座主编, Chinese Journal of Biology (The Editorial Board)编委。
基金资助:
National Natural Science Foundation of China (Grant Nos. 31471338, 81260338).

Research progress on the antioxidant therapy for gastric cancer

Lina Yu, Caixia Gao, Jun Ma, Wenjin Hao, Qiusheng Zheng^*

Binzhou Medical University, Yantai 264000, China

Received:2015-12-17 Revised:2016-02-22 Online:2016-06-29 Published:2016-04-07
Contact: Tel.: +86-13963871815, E-mail: zqsyr@sohu.com
About author:Professor Qiusheng Zheng is the “splendid elite” in 21st century authorized by the Ministry of Education. He is the candidate expert on the technical management in the field of medicine belong to the major projects in the 12th Five-Year Plan of National science and technology program. He is the chief director of the key laboratory from the Ministry of Education on special plant medicine resources in Xinjiang. He is one of the members of the experts in the technical committee of the innovation strategic alliance of industry technology on the North-west natural medicine (Chinese-Tibetan Medicine) and the expert database in the science and technology plan of National High-tech R&D Program (863 Program). He is one of the members of the expert groups in the National Degree and Postgraduate Education. He is the guest professor of Lanzhou University and Ocean University of China and the distinguished visiting professor honored as “The oasis scholar” of Shihezi University. He is the academic leader of the provincial key discipline in pharmacology. He is the general leader of approximately 20 major research projects including the major drug development in the science and technology projects by Ministry of Science and Technology, the support plan of the National Science and Technology projects, preliminary work of National Basic Research Program of China (973 Program) and the projects in Natural Science Foundation of China (NSFC). He has participated in more than 10 evaluation researches of new drug development project and applied more than 10 associated patents. He has published 160 academic journal papers and 5 books. He won the first prize of Provincial science and technology progress award for 2 times and second prize for 5 times. He is the Guest editor of Journal of Chemistry and the Editorial Board of Chinese Journal of Biology at present time.
Supported by:
National Natural Science Foundation of China (Grant Nos. 31471338, 81260338).

摘要/Abstract

摘要：

胃癌是全球常见的恶性肿瘤之一,许多因素包括幽门螺杆菌感染、慢性炎症、遗传等均可导致胃癌。其中,幽门螺杆菌感染可显著增加活性氧(ROS)和活性氮(RNS)在胃中的产生,会导致氧化应激,而氧化应激是胃肠溃疡和癌症的重要发病机理。由于手术和化疗等治疗方法具有很大的副作用,抗氧化治疗受到越来越多的关注。抗氧化治疗系统主要包括各种抗氧化剂(超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶和肌肽)和起预防作用的中草药,如茶多酚、白藜芦醇和维生素等。本文我们旨在对于胃癌相关的风险因素、氧化应激和抗氧化剂治疗的致病机理作出一些简短的总结。

关键词: 胃癌, 幽门螺杆菌, COX-2, ROS/RNS, 氧化应激, 抗氧化疗法

Abstract:

Gastric cancer is one of common malignant tumors from a global perspective, and its morbidity ranks the forth and also the second largest cause of cancer-related death worldwide. Many factors can cause gastric cancer, including helicobacter pylori infection, chronic inflammation, genetic factors et al. Among all of these, helicobacter pylori infection can significantly increase the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in human stomach, which can cause the oxidative stress. Oxidative stress plays an important role in the pathogenesis of gastro-intestinal diseases such as mucosal damage, gastro-intestinal ulcers and cancer. Modern therapeutic treatments such as surgery and chemotherapy have undesired side effects, so the antioxidant therapy gains more and more attentions. Antioxidant therapy system comprises of various antioxidants (SOD, catalase, glutathione peroxidase and carnosine) and Chinese herbal medicine, which is mainly focused on the chemoprevention. Natural products and their derivatives, such as tea polyphenol, resveratrol and vitamins, have some potential benefits on their chemoprevention. Besides, much work has been done to understand the role of dietary factors playing in the prevention of gastrointestinal cancers. In this review based on some valuable studies, we aim to make some brief summaries about risk factors, pathogenic mechanism of oxidative stress and antioxidants therapy in gastric cancer.

Key words: Gastric cancer, Helicobacter pylori, COX-2, ROS/RNS, Oxidant stress, Antioxidant therapy

中图分类号:

Supporting:

于丽娜, 高彩霞, 马俊, 郝雯瑾, 郑秋生. 胃癌抗氧化治疗的研究进展[J]. 中国药学(英文版), 2016, 25(6): 466-476.

Lina Yu, Caixia Gao, Jun Ma, Wenjin Hao, Qiusheng Zheng. Research progress on the antioxidant therapy for gastric cancer[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(6): 466-476.

参考文献

[1] Jemal, A.; Bray, F.; Center, M.M.; Ferlay, J.; Ward, E.; Forman, D. CA Cancer J. Clin. 2011, 61, 69-90.
[2] Parkin, D.M.; Bray, F.I.; Devesa, S.S. Eur. J. Cancer. 2001, 37, S4-66.
[3] Handa, O.; Naito, Y.; Yoshikawa, T. Inflamm. Res. 2010, 59, 997-1003.
[4] Su, Z.Y.; Shu, L.; Khor, T.O.; Lee, J.H.; Fuentes, F.; Kong, A.N. Top Curr. Chem. 2013, 133-162.
[5] Tamimi, R.M.; Lagiou, P.; Adami, H.O.; Trichopoulos, D. J. Intern. Med. 2002, 251, 286-300.
[6] Sihvo, E.I.; Salminen, J.T.; Rantanen, T.K.; Rämö, O.J.; Ahotupa, M.; Färkkilä, M.; Auvinen, M.I.; Salo, J.A. Int. J. Cancer. 2002, 102, 551-555.
[7] Halici, M.; Odabasoglu, F.; Suleyman, H.; Cakir, A.; Aslan, A.; Bayir, Y. Phytomedicine. 2005, 12, 656-662.
[8] De, Martel, C.; Ferlay, J.; Franceschi, S.; Vignat, J.; Bray, F.; Forman, D.; lummer, M. Lancet Oncol. 2012, 13, 607-615.
[9] Webb, P.M.; Knight, T.; Greaves, S.; Wilson, A.; Newell, D.G.; Elder, J.; Forman, D. BMJ. 1994, 308, 750-753.
[10] Yaghoobi, M.; Bijarchi, R.; Narod, S.A. Br. J. Cancer. 2010, 102, 237-242.
[11] Shin, C.M.; Kim, N.; Lee, H.S.; Lee, D.H.; Kim, J.S.; Jung, H.C.; Song, I.S. Eur. J. Gastroenterol. Hepatol. 2011, 23, 411-417.
[12] Wang, G.; Alamuri, P.; Maier, R.J. Mol. Microbiol. 2006, 61, 847-860.
[13] Malfertheiner, P.; Megraud, F.; O'Morain, C.A.; Atherton, J.; Axon, A.T.; Bazzoli, F.; Gensini, G.F.; Gisbert, J.P.; Graham, D.Y.; Rokkas, T.; El-Omar, E.M.; Kuipers, E.J. Gut. 2012, 61, 646-664.
[14] Robbins, D.; Zhao, Y. J. Signal. Transduct. 2012, 2012, 101465.
[15] Shibata, D.; Weiss, L.M. Am. J. Pathol. 1992, 140, 769-774.
[16] Iizasa, H.; Nanbo, A.; Nishikawa, J.; Jinushi, M.; Yoshiyama, H. Viruses. 2012, 4, 3420-3439.
[17] Hofman, P.; Waidner, B.; Hofman, V.; Bereswill, S.; Brest, P.; Kist, M. Helicobacter. 2004, 1, 15-22.
[18] Wang, D.; Dubois, R.N. Gut. 2006, 55, 1, 115-122.
[19] Oshima, H.; Hioki, K.; Popivanova, B.K.; Oguma, K.; Rooijen, N.; Ishikawa, T.O.; Oshima, M. Gastroenterology. 2011, 140, 596-607.
[20] Brown, J.R.; DuBois, R.N. J. Clin. Oncol. 2005, 23, 2840-2855.
[21] Uefuji, K.; Ichikura, T.; Mochizuk, H. Clin. Cancer Res. 2000, 6, 135-138.
[22] Strillacci, A.; Griffoni, C.; Sansone, P.; Paterini, P.; Piazzi, G.; Lazzarini, G.; Spisni, E.; Pantaleo, M.A.; Biasco, G.; Tomasi, V. Exp. Cell Res. 2009, 315, 1439-1447.
[23] Kong, D.; Piao, Y.S.; Yamashita, S.; Oshima, H.; Oguma, K.; Fushida, S.; Fujimura, T.; Minamoto, T.; Seno, H.; Yamada, Y.; Satou, K.; Ushijima, T.; Ishikawa, T.O.; Oshima, M. Oncogene. 2012, 31, 3949-3960.
[24] Uefuji, K.; Ichikura, T.; Mochizuki, H. Clin. Cancer Res. 2000, 6, 135-138.
[25] Halliwell, B. Annu. Rev. Nutr. 1996, 16, 33-50.
[26] Ames, B.N.; Shigenaga, M.K.; Hagen, T.M. Proc. Natl. Acad. Sci. USA. 1993, 90, 7915-7922.
[27] Sullivan, L.B.; Chandel, N.S. Cancer Metab. 2014, 2, 17.
[28] IBSEN, K.H. Cancer Res. 1961, 21, 829-841.
[29] Wu, M.; Neilson, A.; Swift, A.L.; Moran, R.; Tamagnine, J.; Parslow, D.; Armistead, S.; Lemire, K.; Orrell, J.; Teich, J.; Chomicz, S.; Ferrick, D.A. Am. J. Physiol. Cell Physiol. 2007, 292, C125-C136.
[30] Floyd, R.A.; Watson, J.J.; Wong, P.K.; Altmille, D.H.; Rickard, R.C. Free Radic. Res. Commun. 1986, 1, 163-172.
[31] Ding, S.Z.; Minohara, Y.; Fan, X.J.; Wang, J.; Reyes, V.E.; Patel, J.;, Dirden-Kramer, B.; Boldogh, I.; Ernst, P.B.; Crowe, S.E. Infect Immun. 2007, 75, 4030-4039.
[32] Lee, J.H.; Lee, D.U.; Jeong, C.S. Food Chem. Toxicol. 2009, 47, 1127-1131.
[33] Park, J.H.; Kim, T.Y.; Jong, H.S.; Kim, T.Y.; Chun, Y.S.; Park, J.W.; Lee, C.T.; Jung, H.C.; Kim, N.K.; Bang, Y.J. Clin. Cancer Res. 2003, 9, 433-440.
[34] O’Ryan, M.L.; Lucero, Y.; Rabello, M.; Mamani, N.; Salinas, A.M.; Peña, A.; Torres-Torreti, J.P.; Mejías, A.; Ramilo, O.; Suarez, N.; Reynolds, H.E.; Orellana, A.; Lagomarcino, A.J. Clin. Infect. Dis. 2015, 61, 211-218.
[35] Handa, O.; Naito, Y.; Yoshikawa, T. Redox Rep. 2011, 16, 1-7.
[36] Shi, Y.Y.; Chen, M.; Zhang, Y.X.; Zhang, J.; Ding, S.G. J. Zhejiang Univ. Sci. B. 2014, 15, 500-506.
[37] Ritz, D.; Beckwith, J. Annu. Rev. Microbiol. 2001, 55, 21-48.
[38] Zhang, Y.N.; Ding, S.G.; Huang, L.H.; Zhang, J.; Shi, Y.Y.; Zhong, L.J. J. Zhejiang Univ. Sci. B. 2011, 12, 820-827.
[39] Annibale, B.; Capurso, G.; Fave, G. Dig. Liver Dis. 2002, 2, S72-S77.
[40] Chaudière, J.; Ferrari-Iliou, R. Food Chem. Toxicol. 1999, 37, 949-962.
[41] Sullivan, L.B.; Chandel, N.S. Cancer Metab. 2014, 2, 17.
[42] Buetler, T.M.; Krauskopf, A.; Ruegg, U.T. News Physiol. Sci. 2004, 19, 120-123.
[43] Landis, G.N.; Tower, J. Mech. Ageing Dev. 2005, 126, 365-379.
[44] Zelko, I.N.; Mariani, T.J.; Folz, R.J. Free Radic. Biol. Med. 2002, 33, 337-349.
[45] Attatippaholkun, W.; Wikainapaku, l.K. Asian Pac. J. Cancer Prev. 2013, 14, 3955-3961.
[46] Hur, G.C.; Cho, S.J.; Kim, C.H.; Kim, M.K.; Bae, S.; Nam, S.Y.; Park, J.W.; Kim, W.H.; Lee, B.L. Clin. Cancer Res. 2003, 9, 5768-5775.
[47] Masella, R.; Benedetto, R.; Varì, R.; Filesi, C.; Giovannini, C. J. Nutr. Biochem. 2005, 16, 577-586.
[48] Aburatani, H.; Hippo, Y.; Ishida, T.; Takashima, R.; Matsuba, C.; Kodama, T.; Takao, M.; Yasui, A.; Yamamoto, K.; Asano, M. Cancer Res. 1997, 57, 2151-2156.
[49] Michiels, C.; Raes, M.; Toussaint, O.; Remacle, J. Free Radic. Biol. Med. 1994, 17, 235-248.
[50] Dreher, D.; Junod, A.F. J. Eur. J. Cancer. 1996, 32A, 30-38.
[51] Wang, J.Y.; Yang, I.P.; Wu, D.C.; Huang, S.W.; Wu, J.Y.; Juo, S.H. Clin. Chim. Acta. 2010, 411, 19-20, 1432-1436.
[52] Agnani, D.; Camacho-Vanegas, O.; Camacho, C.; Lele, S.; Odunsi, K.; Cohen, S.; Dottino, P.; Martignetti, J.A. J. Ovarian Res. 2011, 4, 18.
[53] Martín Mateo, M.C.; Martín, B.; Santos, M.; Rabadán, J. Biol. Trace Elem. Res. 1997, 57, 79-90.
[54] Vo, T.K.; Druez, C.; Delzenne, N.; Taper, H.S.; Roberfroid, M. Carcinogenesis. 1988, 9, 2009-2013.
[55] Goldstein, B.D.; Czerniecki, B.; Witz, G. Environ. Health Perspect. 1989, 81, 55-57.
[56] Kewitz, S.; Volkmer, I.; Staege, M.S. Cancer Growth Metastasis. 2013, 6, 35-52.
[57] Liang, T.; Zhang, X.; Xue, W.; Zhao, S.; Zhang, X.; Pei, J. Int. J. Mol. Sci. 2014, 15, 15754-15765.
[58] Li, Y.; Hu, Y.; Shi, S.; Jiang, L. Int. J. Biol. Macromol. 2014, 68, 113-116.
[59] Liu, M.L.; Zhang, S.J. J. BUON. 2014, 19, 713-717.
[60] Lin, L.L.; Hsia, C.R.; Hsu, C.L.; Huang, H.C.; Juan, H.F. BMC Genomics. 2015, 16, 41.
[61] Iacopini, F.; Consolazio, A.; Bosco, D.; Marcheggiano, A.; Bella, A.; Pica, R.; Paoluzi, O.A.; Crispino, P.; Rivera, M.; Mottolese, M.; Nardi, F.; Paoluzi, P. Helicobacter. 2003, 8, 503-512.
[62] Acar, U.; Atilgan, H.I.; Acar, D.E.; Yalniz-Akkaya, Z.; Yumusak, N.; Korkmaz, M.; Koca, G. Ann. Nucl. Med. 2013, 27, 886-891.
[63] Prasad, K.N.; Edwards-Prasad, J. J. Am. Coll. Nutr. 1990, 9, 28-34.
[64] Wattenberg, L.W. Cancer Res. 1992, 52, 2085-2091.
[65] Scholar, E.M.; Wolterman, K.; Birt, D.F.; Bresnick, E. Nutr. Cancer. 1989, 12, 121-126.
[66] Prasad, K.N.; Edwards-Prasad, J. J. Am. Coll. Nutr. 1992, 11, 487-500.
[67] Shah, C.P.; Svoboda, T.; Goel, S. Canadian. J. Public Health. 1996, 87, 272-274.
[68] Sun, Y.Q.; Girgensone, I.; Leanderson, P.; Petersson, F.; Borch, K. Helicobacter. 2005, 10, 33-42.
[69] Mirvish, S.S. Cancer. 1986, 58, 1842-1850.
[70] Everett, S.M.; Drake, I.M.; White, K.L.; Mapstone, N.P.; Chalmers, D.M.; Schorah, C.J.; Axon, A.T. Br. J. Nutr. 2002, 87, 3-11.
[71] Aditi, A.; Graham, D.Y. Dig. Dis. Sci. 2012, 57, 2504-2515.
[72] Wilson, J.X. Ann. Rev. Nutr. 2005, 25, 105-125.
[73] Zhang, Z.W.; Farthing, M.J. Chin. J. Dig. Dis. 2005, 6, 53-58.
[74] Iacopini, F.; Consolazio, A.; Bosco, D.; Marcheggiano, A.; Bella, A.; Pica, R.; Paoluz,i O.A.; Crispino, P.; Rivera, M.; Mottolese, M.; Nardi, F.; Paoluzi, P. Helicobacter. 2003, 8, 503-512.
[75] Drake, I.M.; Davies, M.J.; Mapstone, N.P.; Dixon, M.F.; Schorah, C.J.; White, K.L.; Chalmers, D.M.; Axon, A.T. Carcinogenesis. 1996, 17, 559-562.
[76] Liu, C.; Russell, R.M. Nutr. Rev. 2008, 66, 237-249.
[77] Bolhassani, A.; Khavari, A.; Bathaie, S.Z. Biochim. Biophys. Acta. 2014, 1845, 20-30.
[78] Velmurugan, B.; Mani, A.; Nagini, S. Eur. J. Cancer Prev. 2005, 14, 387-393.
[79] Velmurugan, B.; Nagini, S. J. Med. Food. 2005, 8, 494-501.
[80] Krinsky, N.I.; Johnson, E.J. Mol. Aspects Med. 2005, 26, 459-516.
[81] Liu, C.; Russell, R.M.; Wang, X.D. J. Nutr. 2006, 136, 106-111.
[82] Kelley, D.S.; Bendich, A. Am. J. Clin. Nutr. 1996, 63, 994S-996S.
[83] Liu, B.H.; Lee, Y.K. Int. Immunopharmacol. 2003, 3, 979-986.
[84] Di Mascio, P.; Kaiser, S.; Sies, H. Arch Biochem. Biophys. 1989, 274, 532-538.
[85] Liu, C.C.; Huang, C.C.; Lin, W.T.; Hsieh, C.C.; Huang, S.Y.; Lin, S.J.; Yang, S.C. Br. J. Nutr. 2005, 94, 595-601.
[86] Gunasekera, R.S.; Sewgobind, K.; Desai, S.; Dunn, L.; Black, H.S.; McKeehan, W.L.; Patil, B. Nutr. Cancer. 2007, 58, 171-177.
[87] Dias, M.C.; Vieiralves, N.F.; Gomes, M.I.; Salvadori, D.M.; Rodrigues, M.A.; Barbisan, L.F. Food Chem. Toxicol. 2010, 48, 772-780.
[88] Karppi, J.; Kurl, S.; Nurmi, T.; Rissanen, T.H.; Pukkala, E.; Nyyssönen, K. Ann. Epidemiol. 2009, 19, 512-518.
[89] Tang, F.Y.; Cho, H.J.; Pai, M.H.; Chen, Y.H. J. Nutr. Biochem. 2009, 20, 426-434.
[90] Velmurugan, B.; Bhuvaneswari, V.; Nagini, S. Fitoterapia. 2002, 73, 7-8, 604-611.
[91] Wu, W.K.; Sung, J.J.; Lee, C.W.; Yu, J.; Cho, C.H. Cancer Lett. 2010, 295, 7-16.
[92] Bhattacharyya, A.; Chattopadhyay, R.; Mitra, S.; Crowe, S.E. Physiol. Rev. 2014, 94, 329-354.

胃癌抗氧化治疗的研究进展

Research progress on the antioxidant therapy for gastric cancer

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	陈小青, 彭波, 姜红梅, 张昌旭, 李海燕, 李子银. 丹酚酸B通过介导SIRT3/FOXO1信号通路减轻非酒精性脂肪肝的氧化应激反应[J]. 中国药学(英文版), 2022, 31(9): 698-710.
[2]	王子翼, 刘晓岩, 朱元军, 刘晔, 张平平, 王银叶. W026B对大鼠全脑缺血再灌注损伤的保护作用[J]. 中国药学(英文版), 2022, 31(2): 108-116.
[3]	吕慧婕, 许拓, 彭俊, 罗刚, 何剑琴, 杨丝丝, 张天成, 奉水东, 凌宏艳. 氢杨梅素改善高脂饮食诱导的肥胖小鼠肝脏脂肪沉积及机制[J]. 中国药学(英文版), 2022, 31(11): 824-839.
[4]	张明康, 陈宇玥, 周燕, 武新安. 槲皮素对四氯化碳致大鼠肝纤维化的缓解作用及其机制研究[J]. 中国药学(英文版), 2022, 31(11): 840-852.
[5]	韩春杨, 孙桃桃, 范广太, 刘亚伟, 刘翠艳. 黄精通过氧化应激和线粒体凋亡途径保护CCl4诱导的大鼠急性肝损伤[J]. 中国药学(英文版), 2021, 30(4): 306-318.
[6]	李荣, 宋利华, 刘杰, 白杨, 杜玉茗, 林春华, 苏秀媛, 于宗学. 利格列汀对糖尿病Wistar大鼠心脏保护作用的研究[J]. 中国药学(英文版), 2021, 30(4): 334-346.
[7]	黄晋, 杨玲馨, 杨宁, 袁博文, 张浩, 王梦月. 荨麻抑制前列腺增生药理作用研究[J]. 中国药学(英文版), 2020, 29(4): 236-243.
[8]	王玉鹏, 孙懿, 蒲小平. 内源性抗氧化蛋白DJ-1: 弱精症治疗的潜在靶点[J]. 中国药学(英文版), 2017, 26(10): 697-708.
[9]	冀莎莎, 雷芸, 黄霄天, 高志芹. β-二氢沉香呋喃倍半萜抗Aβ25-35诱导的神经细胞凋亡和氧化损伤的保护作用[J]. 中国药学(英文版), 2016, 25(8): 582-589.
[10]	李方园, 张贵育, 欧日兰, 王莹, 戚笑笑, 刘中秋, 卢琳琳. 中草药对幽门螺旋杆菌导致的胃癌的预防作用[J]. 中国药学(英文版), 2016, 25(4): 250-265.
[11]	杨倩, 陈刚, 杨洋, 蔡雪婷, 庞中化, 胡春萍, 张双全, 曹鹏. 刺芒柄花素通过诱导Nrf2表达缓解DSS诱导的小鼠溃疡性结肠炎[J]. 中国药学(英文版), 2016, 25(3): 178-188.
[12]	张聪慧, 王秀伶, 梁晓琳, 张红蕾, 郝庆红. 左旋-5羟基-雌马酚对秀丽隐杆线虫寿命及抗性的影响[J]. 中国药学(英文版), 2014, 23(6): 378-384.
[13]	吴妮, 徐嵬, 张友波, 杨秀伟. 马拉巴酮C的大鼠肝微粒体生物转化及其体外对人胃癌细胞株的细胞毒活性研究[J]. 中国药学(英文版), 2014, 23(4): 241-245.
[14]	王增, 蔡鑫君, 刘孟娟, 卢红阳, 林能明. 年龄、性别及2型糖尿病对于胃癌发生的风险: 一项单一机构的回顾性分析[J]. 中国药学(英文版), 2014, 23(11): 799-803.
[15]	司霞, 马卓, 陈月, 黄琳, 冯婉玉*. 20-羟基蜕皮甾酮对H2O2诱导SH-SY5Y细胞损伤的保护作用[J]. 中国药学(英文版), 2014, 23(1): 33-38.