中草药对幽门螺旋杆菌导致的胃癌的预防作用

doi:10.5246/jcps.2016.04.029

中国药学(英文版) ›› 2016, Vol. 25 ›› Issue (4): 250-265.DOI: 10.5246/jcps.2016.04.029

• 【传统中药和植物药的癌症预防专栏】 • 上一篇下一篇

中草药对幽门螺旋杆菌导致的胃癌的预防作用

李方园, 张贵育, 欧日兰, 王莹, 戚笑笑, 刘中秋, 卢琳琳^*

广州中医药大学国际中医药转化医学研究所, 广东广州 510006

收稿日期:2015-11-26 修回日期:2015-12-26 出版日期:2016-04-21 发布日期:2015-12-28
通讯作者: Tel.: +86-20-39357902, Fax: +86-20-39358071, E-mail: lllu@gzucm.edu.cn
作者简介:卢琳琳, 2014 年毕业于南方医科大学药学院获得博士学位, 药剂学专业。2014年起在广州中医药大学国际中医药转化医学研究所工作。目前作为第一负责人承担国家自然科学基金、广东省自然科学基金等项目的研究工作。主要研究方向包括: (1) 药物代谢酶在 HBV诱导的肝癌中的作用及分子机制; (2) 中草药对肺癌的化学预防及分子机制。
基金资助:
Natural Science Foundation of China (Grant No. 81120108025) and the Science and Technology Department of Guangzhou City (Grant No. 201509010004).

The role of Helicobacter pylori infection in gastric carcinogenesis and its prevention by using Chinese medicinal herbs

Fangyuan Li, Guiyu Zhang, Rilan Ou, Ying Wang, Xiaoxiao Qi, Zhongqiu Liu, Linlin Lu^*

International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China

Received:2015-11-26 Revised:2015-12-26 Online:2016-04-21 Published:2015-12-28
Contact: Tel.: +86-20-39357902, Fax: +86-20-39358071, E-mail: lllu@gzucm.edu.cn
About author:Linlin Lu graduated from Southern Medical University in 2014 and obtained her Doctorate degree, majoring in pharmacy. After graduation, she was working in the International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine. At present, she is charge of National Science Foundation, Natural Science Foundation of Guangdong Province and other research projects. Her research interests include: (1) The effects and molecular mechanism of metabolic enzymes in HBV-induced HCC; (2) The chemoprevention and molecular mechanism of Chinese herbal medicine on lung cancer.
Supported by:
Natural Science Foundation of China (Grant No. 81120108025) and the Science and Technology Department of Guangzhou City (Grant No. 201509010004).

摘要/Abstract

摘要：

胃癌是全球最常见的恶性肿瘤之一,发病率和死亡率分别居于第五和第三,不仅危害着人类的健康,也给人类带来了很大的经济负担。幽门螺旋杆菌感染导致胃部炎症的发生,长期的炎症刺激导致胃上皮发生异型增生,最终发展成胃癌。幽门螺旋杆菌的致病因子在炎症到胃癌的发生中起着重要的作用,包括尿素酶、鞭毛、空泡毒素(VacA)、细胞毒素相关抗原(CagA)等。而这些致病因子诱发炎症的机制主要是启动了NF-κB通路, MAPK通路以及氧化应激,这三者之间也存在内在的联系。临床上治疗胃部炎症以及胃癌主要以抗生素、化疗药和外科手术为主,然而抗生素耐药、化疗药物的副作用以及术后复发使得治疗结果并不理想。因此,化学预防的提出给肿瘤的治疗提供了新的方向,特别是中草药的化学预防成为了研究的热点。本文主要总结了中草药对幽门螺旋杆菌导致胃癌的预防作用及其相关机制和治疗前景。

关键词: 胃癌, 幽门螺旋杆菌, 致病因子, 炎症, 中草药, 化学预防

Abstract:

As the fifth most common cancer and the third most common cause of cancer deaths worldwide, gastric cancer remains a significant public health concern and an economic burden in developed and developing countries. Gastric inflammation induced by Helicobacter pylori may initiate superficial gastritis, which then progresses to atrophic gastritis, gastric epithelial dysplasia, and finally gastric cancer. The pathogenesis of H. pylori infection is related to its virulence factors, including urease, flagella, vacuolating cytotoxin A and cytotoxin-associated gene antigen. The relevant mechanisms of H. pylori-induced inflammation include activation of nuclear factor-κB, mitogen-activated protein kinase pathway, and oxidative stress. To date, therapeutic strategies and results in this infection remain undesirable. Complicated treatment issues include antibiotic resistance, adverse effects of chemical drugs, and recurrence after operation. Therefore, chemoprevention has been regarded as an important measure, and Chinese medicinal herbs have been the research hotspot. This review aimed to summarize the effects of Chinese medicinal herbs on the prevention of gastric cancer, mechanism of action and the treatment prospects, with emphasis H. pylori-induced effects.

Key words: Gastric cancer, H. pylori, Virulence factors, Inflammation, Medicinal plants, Chemoprevention

中图分类号:

R962

Supporting:

李方园, 张贵育, 欧日兰, 王莹, 戚笑笑, 刘中秋, 卢琳琳. 中草药对幽门螺旋杆菌导致的胃癌的预防作用[J]. 中国药学(英文版), 2016, 25(4): 250-265.

Fangyuan Li, Guiyu Zhang, Rilan Ou, Ying Wang, Xiaoxiao Qi, Zhongqiu Liu, Linlin Lu. The role of Helicobacter pylori infection in gastric carcinogenesis and its prevention by using Chinese medicinal herbs[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(4): 250-265.

参考文献

[1] International Agency for Research on Cancer. Available from: URL: http://globocan.iarc.fr/
[2] Fock, K.M.; Ang, T.L. J. Gastroenterol. Hepatol. 2010, 25, 479-486.
[3] Correa, P.; Piazuelo, M.B. Dig. Liver. Dis. 2008, 40, 490-496.
[4] Chen, Y.C.; Wang, Y.; Li, J.Y.; Xu, W.R.; Zhang, Y.L. World J. Gastroenterol. 2006, 12, 5972-5977.
[5] Liu, Z.; Xu, X.; Chen, L.; Li, W.; Sun, Y.; Zeng, J.; Yu, H.; Chen, C.; Jia, J. J. Cell. Biochem. 2012, 113, 1080-1086.
[6] Chiba, T.; Marusawa, H.; Seno, H.; Watanabe, N. J. Gastroenterol. Hepatol. 2008, 23, 1175-1181.
[7] Rahman, R.; Asombang, A.W.; Ibdah, J.A. World J. Gastroenterol. 2014, 20, 4483-4490.
[8] Zou, X.M. World J. Gastroenterology. 2008, 14, 4810.
[9] de Martel, C.; Forman, D.; Plummer, M. Gastroenterol Clin. North Am. 2013, 42, 219-240.
[10] Ladeiras-Lopes, R.; Pereira, A.K.; Nogueira, A.; Pinheiro-Torres, T.; Pinto, I.; Santos-Pereira, R.; Lunet, N. Cancer Causes Control. 2008, 19, 689-701.
[11] Shi, J.; Qu, Y.P.; Hou, P. World J. Gastroenterol. 2014, 20, 13804-13819.
[12] Malfertheiner, P.; Megraud, F.; O'Morain, C.A.; Atherton, J.; Axon, A.T.; Bazzoli, F.; Gensini, G.F.; Gisbert, J.P.; Graham, D.Y.; Rokkas, T.; El-Omar, E.M.; Kuipers, E.J. Gut. 2012, 61, 646-664.
[13] Smith, S.M.; O'Morain, C.; McNamara, D. World J. Gastroenterol. 2014, 20, 9912-9921.
[14] Smith, S.M. World J. Gastrointest. Pathophysiol. 2014, 5, 133-146.
[15] Shigematsu, Y.; Niwa, T.; Rehnberg, E.; Toyoda, T.; Yoshida, S.; Mori, A.; Wakabayashi, M.; Iwakura, Y.; Ichinose, M.; Kim, Y.J.; Ushijima, T. Cancer Lett. 2013, 340, 141-147.
[16] Huang, Q.; Lan, F.; Wang, X.; Yu, Y.; Ouyang, X.; Zheng, F.; Han, J.; Lin, Y.; Xie, Y.; Xie, F.; Liu, W.; Yang, X.; Wang, H.; Dong, L.; Wang, L.; Tan, J. Mol. Cancer. 2014, 13, 18.
[17] He, B.S.; Pan, Y.Q.; Xu, Y.F.; Zhu, C.; Qu, L.L.; Wang, S.K. Dig. Dis. Sci. 2011, 56, 2017-2023.
[18] Lee, K.E.; Khoi, P.N.; Xia, Y.; Park, J.S.; Joo, Y.E.; Kim, K.K.; Choi, S.Y.; Jung, Y.D. World J. Gastroenterol. 2013, 19, 8192-8202.
[19] Kuai, W.X.; Wang, Q.; Yang, X.Z.; Zhao, Y.; Yu, R.; Tang, X.J. World J. Gastroenterol. 2012, 18, 979-985.
[20] Li, A.; Dubey, S.; Varney, M.L.; Dave, B.J.; Singh, R.K. J. Immunol. 2003, 170, 3369-3376.
[21] Xue, H.; Liu, J.; Lin, B.; Wang, Z.; Sun, J.; Huang, G. PLoS One. 2012, 7, e28083.
[22] Thiel, A.; Mrena, J.; Ristimaki, A. Cancer Metastasis Rev. 2011, 30, 387-395.
[23] Cheng, J.; Fan, X.M. World J. Gastroenterol. 2013, 19, 7361-7368.
[24] Li, Q.; Liu, N.; Shen, B.; Zhou, L.; Wang, Y.; Wang, Y.; Sun, J.; Fan, Z.; Liu, R.H. Cancer Lett. 2009, 278, 97-103.
[25] Lee, I.O.; Kim, J.H.; Choi, Y.J.; Pillinger, M.H.; Kim, S.Y.; Blaser, M.J.; Lee, Y.C. J. Biol. Chem. 2010, 285, 16042-16050.
[26] Yu, H.; Zeng, J.; Liang, X.; Wang, W.; Zhou, Y.; Sun, Y.; Liu, S.; Li, W.; Chen, C.; Jia, J. PLoS One. 2014, 9, e105306.
[27] Tsutsumi, R.; Takahashi, A.; Azuma, T.; Higashi, H.; Hatakeyama, M. Mol. Cell Biol. 2006, 26, 261-276.
[28] Suzuki, M.; Mimuro, H.; Suzuki, T.; Park, M.; Yamamoto, T.; Sasakawa, C. J. Exp. Med. 2005, 202, 1235-1247.
[29] Yamahashi, Y.; Hatakeyama, M. Cell Adh. Migr. 2013, 7, 11-18.
[30] Weydig, C.; Starzinski-Powitz, A.; Carra, G.; Lower, J.; Wessler, S. Exp. Cell Res. 2007, 313, 3459-3471.
[31] Murata-Kamiya, N.; Kurashima, Y.; Teishikata, Y.; Yamahashi, Y.; Saito, Y.; Higashi, H.; Aburatani, H.; Akiyama, T.; Peek, R.M.Jr.; Azuma, T.; Hatakeyama, M. Oncogene. 2007, 26, 4617-4626.
[32] Oguma, K.; Oshima, H.; Oshima, M. Future Oncol. 2010, 6, 515-526.
[33] Mimuro, H.; Suzuki, T.; Tanaka, J.; Asahi, M.; Haas, R.; Sasakawa, C. Mol. Cell. 2002, 10, 745-755.
[34] Churin, Y.; Al-Ghoul, L.; Kepp, O.; Meyer, T.F.; Birchmeier, W.; Naumann, M. J. Cell Biol. 2003, 161, 249-255.
[35] Zhao, J.; Dong, Y.; Kang, W.; Go, M.Y.; Tong, J.H.; Ng, E.K.; Chiu, P.W.; Cheng, A.S.; To, K.F.; Sung, J.J.; Yu, J. Oncoscience. 2014, 1, 468-475.
[36] Palframan, S.L.; Kwok, T.; Gabriel, K. Front. Cell Infect. Microbiol. 2012, 2, 92.
[37] Gupta, V.R.; Patel, H.K.; Kostolansky, S.S.; Ballivian, R.A.; Eichberg, J.; Blanke, S.R. PLoS Pathog. 2008, 4, e1000073.
[38] Sewald, X.; Gebert-Vogl, B.; Prassl, S.; Barwig, I.; Weiss, E.; Fabbri, M.; Osicka, R.; Schiemann, M.; Busch, D.H.; Semmrich, M.; Holzmann, B.; Sebo, P.; Haas, R. Cell Host. Microbe. 2008, 3, 20-29.
[39] Immo, E.S. Mitochondrion. 2001, 1, 3-31.
[40] Calore, F.; Genisset, C.; Casellato, A.; Rossato, M.; Codolo, G.; Esposti, M.D.; Scorrano, L.; de Bernard, M. Cell Death Differ. 2010, 17, 1707-1716.
[41] Watanabe, T.; Tsuge, H.; Imagawa, T.; Kise, D.; Hirano, K.; Beppu, M.; Takahashi, A.; Yamaguchi, K.; Fujiki, H.; Suganuma, M. J. Cancer Res. Clin. Oncol. 2010, 136, 911-921.
[42] Tang, C.L.; Hao, B.; Zhang, G.X.; Shi, R.H.; Cheng, W.F. World J. Gastroenterol. 2013, 19, 399-403.
[43] Suganuma, M.; Watanabe, T.; Yamaguchi, K.; Takahashi, A.; Fujiki, H. Cancer Lett. 2012, 322, 133-138.
[44] Kuzuhara, T.; Suganuma, M.; Kurusu, M.; Fujiki, H. J. Cancer Res. Clin. Oncol. 2007, 133, 287-296.
[45] Watanabe, T.; Takahashi, A.; Suzuki, K.; Kurusu-Kanno, M.; Yamaguchi, K.; Fujiki, H.; Suganuma, M. Int. J. Cancer. 2014, 134, 2373-2382.
[46] Ismail, S.; Hampton, M.B.; Keenan, J.I. Infection Immunity. 2003, 71, 5670-5675.
[47] Chitcholtan, K.; Hampton, M.B.; Keenan, J.I. Carcinogenesis. 2008, 29, 2400-2405.
[48] Choi, I.J. Korean J. Intern. Med. 2013, 28, 525-537.
[49] Lin, J.; Huang, W.W. World J. Gastroenterol. 2009, 15, 4715-4719.
[50] Lu, B.; Li, M. World J. Gastroenterol. 2014, 20, 5660-5665.
[51] Fera, M.T.; Giannone, M.; Pallio, S.; Tortora, A.; Blandino, G.; Carbone, M. Int. J. Antimicrob. Agents. 2001, 17, 151-154.
[52] Park, J.B.; Imamura, L.; Kobashi, K. Biol. Pharm. Bull. 1996, 19, 182-187.
[53] Midolo, P.D.; Norton, A.; von Itzstein, M.; Lambert, J.R. FEMS Microbiol. Lett. 1997, 157, 229-232.
[54] Sorba, G.; Bertinaria, M.; Di Stilo, A.; Gasco, A.; Scaltrito, M.M.; Brenciaglia, M.I.; Dubini, F. Bioorg. Med. Chem. Lett. 2001, 11, 403-406.
[55] Kumar, D.; Dhar, A.; Dattagupta, S.; Ahuja, V.; Mathur, M.; Sharma, M.P. Indian J. Gastroenterol. 2002, 21, 7-10.
[56] Wu, J.; Hu, D.; Wang, K.X. J. Chin. Med. Mater. 2008, 31, 707-710.
[57] Yu, X.D.; Zheng, R.B.; Xie, J.H.; Su, J.Y.; Huang, X.Q.; Wang, Y.H.; Zheng, Y.F.; Mo, Z.Z.; Wu, X.L.; Wu, D.W.; Liang, Y.E.; Zeng, H.F.; Su, Z.R.; Huang, P. J. Ethnopharmacol. 2015, 162, 69-78.
[58] Yu, X.D.; Xie, J.H.; Wang, Y.H.; Li, Y.C.; Mo, Z.Z.; Zheng, Y.F.; Su, J.Y.; Liang, Y.E.; Liang, J.Z.; Su, Z.R.; Huang, P. Phytother. Res. 2015, 29, 67-72.
[59] Lee, H.K.; Song, H.E.; Lee, H.B.; Kim, C.S.; Koketsu, M.; Ngan, L.T.; Ahn, Y.J. PLoS One. 2014, 9, e95530.
[60] Pastene, E.; Parada, V.; Avello, M.; Ruiz, A.; Garcia, A. Phytother. Res. 2014, 28, 1637-1645.
[61] Cai, J.; Kim, T. S.; Jang, J. Y.; Kim, J.; Shin, K.; Lee, S.P.; Choi, E.K.; Kim, S.H.; Park, M.; Kim, J.B.; Kim, Y.B. Lab. Anim. Res. 2014, 30, 28-34.
[62] Moon, S.H.; Lee, J.H.; Kim, K.T.; Park, Y.S.; Nah, S.Y.; Ahn, D.U.; Paik, H.D. Int. J. Environ. Res. Public Health. 2013, 10, 5459-5469.
[63] Amin, M.; Anwar, F.; Naz, F.; Mehmood, T.; Saari, N. Molecules. 2013, 18, 2135-2149.
[64] Ngan, L.T.; Moon, J.K.; Shibamoto, T.; Ahn, Y.J. J. Agric. Food Chem. 2012, 60, 9062-9073.
[65] Tharmalingam, N.; Kim, S. H.; Park, M.; Woo, H.J.; Kim, H.W.; Yang, J.Y.; Rhee, K.J.; Kim, J.B. Infect Agent Cancer. 2014, 9, 43.
[66] O’Mahony, R.; Al-Khtheeri, H.; Weerasekera, D.; Fernando, N.; Vaira, D.; Holton, J.; Basset, C. World J. Gastroenterol. 2005, 11, 7499-7507.
[67] Wittschier, N.; Faller, G.; Hensel, A. J. Ethnopharmacol. 2009, 125, 218-223.
[68] Wittschier, N.; Faller, G.; Hensel, A. Phytomedicine. 2007, 14, 285-288.
[69] Asha, M.K.; Debraj, D.; Prashanth, D.; Edwin, J.R.; Srikanth, H.S.; Muruganantham, N.; Dethe, S.M.; Anirban, B.; Jaya, B.; Deepak, M.; Agarwal, A. J. Ethnopharmacol. 2013, 145, 581-586.
[70] Cui, K.; Lu, W.; Zhu, L.; Shen, X.; Huang, J. Biochem. Biophys Res. Commun. 2013, 435, 289-294.
[71] De, R.; Kundu, P.; Swarnakar, S.; Ramamurthy, T.; Chowdhury, A.; Nair, G.B.; Mukhopadhyay, A.K. Antimicrob. Agents Chemother. 2009, 53, 1592-1597.
[72] Zhang, L.; Kong, Y.; Wu, D.; Zhang, H.; Wu, J.; Chen, J.; Ding, J.; Hu, L.; Jiang, H.; Shen, X. Protein Sci. 2008, 17, 1971-1978.
[73] Kim, S.H.; Park, M.; Woo, H.; Tharmalingam, N.; Lee, G.; Rhee, K.J.; Eom, Y.B.; Han, S.I.; Seo, W.D.; Kim, J.B. Int. J. Med. Sci. 2012, 9, 838-842.
[74] Kim, S.H.; Woo, H.; Park, M.; Rhee, K.J.; Moon, C.; Lee, D.; Seo, W.D.; Kim, J.B. Int. J. Med. Sci. 2014, 11, 742-747.
[75] Kim, J.M.; Kim, K.M.; Park, E.H.; Seo, J.H.; Song, J.Y.; Shin, S.C.; Kang, H.L.; Lee, W.K.; Cho, M.J.; Rhee, K.H.; Youn, H.S.; Baik, S.C. Microbiol. Immunol. 2013, 57, 366-373.
[76] Wang, Y.C.; Huang, K.M. Food Chem. Toxicol. 2013, 53, 376-383.
[77] Han, R.M.; Tian, Y.X.; Liu, Y.; Chen, C.H.; Ai, X.C.; Zhang, J.P.; Skibsted, L.H. J. Agric. Food Chem. 2009, 57, 3780-3785.
[78] Kuo, C.H.; Weng, B.C.; Wu, C.C.; Yang, S.F.; Wu, D.C.; Wang, Y.C. J. Ethnopharmacol. 2014, 151, 1031-1039.
[79] Foryst-Ludwig, A.; Neumann, M.; Schneider-Brachert, W.; Naumann, M. Biochem. Biophys. Res. Commun. 2004, 316, 1065-1072.
[80] Zaidi, S.F.; Yamamoto, T.; Refaat, A.; Ahmed, K.; Sakurai, H.; Saiki, I.; Kondo, T.; Usmanghani, K.; Kadowaki, M.; Sugiyama, T. Helicobacter. 2009, 14, 588-595.
[81] Kundu, P.; De, R.; Pal, I.; Mukhopadhyay, A.K.; Saha, D.R.; Swarnakar, S. PLoS One. 2011, 6, e16306.
[82] Santos, A.M.; Lopes, T.; Oleastro, M.; Gato, I.V.; Floch, P.; Benejat, L.; Chaves, P.; Pereira, T.; Seixas, E.; Machado, J.; Guerreiro, A.S. Nutrients. 2015, 7, 306-320.
[83] Sintara, K.; Thong-Ngam, D.; Patumraj, S.; Klaikeaw, N.; Chatsuwan, T. World J. Gastroenterol. 2010, 16, 4039-4046.
[84] Zaidi, S.F.; Ahmed, K.; Yamamoto, T.; Kondo, T.; Usmanghani, K.; Kadowaki, M.; Sugiyama, T. Biol. Pharm. Bull. 2009, 32, 1931-1935.
[85] Kim, J.M.; Kim, K.M.; Park, E.H.; Seo, J.H.; Song, J.Y.; Shin, S.C.; Kang, H.L.; Lee, W.K.; Cho, M.J.; Rhee, K.H.; Youn, H.S.; Baik, S.C. Microbiol Immunol. 2013, 57, 366-373.
[86] Park, J.M.; Park, S.H.; Hong, K.S.; Han, Y.M.; Jang, S.H.; Kim, E.H.; Hahm, K.B. Helicobacter. 2014, 19, 221-236.
[87] Jang, S.H.; Lim, J.W.; Kim, H. J. Physiol. Pharmacol. 2009, 60, Suppl 7: 131-137.
[88] Toyoda, T.; Tsukamoto, T.; Takasu, S.; Shi, L.; Hirano, N.; Ban, H.; Kumagai, T.; Tatematsu, M. Int. J. Cancer. 2009, 125, 1786-1795.
[89] Abdel-Latif, M.M.; Windle, H.J.; Homasany, B.S.; Sabra, K.; Kelleher, D. Br. J. Pharmacol. 2005, 146, 1139-1147.
[90] Wu, H.; Li, W.; Wang, T.; Shu, Y.; Liu, P. Biomed. Pharmacother. 2008, 62, 659-666.
[91] Lee, K.M.; Yeo, M.; Choue, J.S.; Jin, J.H.; Park, S.J.; Cheong, J.Y.; Lee, K.J.; Kim, J.H.; Hahm, K.B. Helicobacter. 2004, 9, 632-642.
[92] Shih, Y.T.; Wu, D.C.; Liu, C.M.; Yang, Y.C.; Chen, I.J.; Lo, Y.C. J. Ethnopharmacol. 2007, 112, 537-544.
[93] Lee, I.O.; Lee, K.H.; Pyo, J.H.; Kim, J.H.; Choi, Y.J.; Lee, Y.C. Helicobacter. 2007, 12, 510-517.
[94] Yamada, T.; Wei, M.; Toyoda, T.; Yamano, S.; Wanibuchi, H. Food Chem. Toxicol. 2014, 70, 107-113.
[95] Gonzalez-Segovia, R.; Quintanar, J.L.; Salinas, E.; Ceballos-Salazar, R.; Aviles-Jimenez, F.; Torres-Lopez, J. J. Gastroenterol. 2008, 43, 441-447.
[96] Takabayashi, F.; Harada, N.; Yamada, M.; Murohisa, B.; Oguni, I. J. Gastroenterol. 2004, 39, 61-63.
[97] Jang, S.H.; Lim, J.W.; Morio, T.; Kim, H. Free Radic. Biol. Med. 2012, 52, 607-615.
[98] Choi, K.S.; Song, H.; Kim, E.H.; Choi, J.H.; Hong, H.; Han, Y.M.; Hahm, K.B. J. Ginseng Res. 2012, 36, 135-145.
[99] Park, S.; Yeo, M.; Jin, J.H.; Lee, K.M.; Kim, S.S.; Choi, S.Y.; Hahm, K.B. Dig. Dis. Sci. 2007, 52, 973-982.
[100] Sekiguchi, H.; Irie, K.; Murakami, A. Biosci. Biotechnol. Biochem. 2010, 74, 1018-1024.
[101] Liu, N.N.; Wang, Y.; Wu, Q. Chin. J. Integr. Med. 2011, 31, 926-931.

中草药对幽门螺旋杆菌导致的胃癌的预防作用

The role of Helicobacter pylori infection in gastric carcinogenesis and its prevention by using Chinese medicinal herbs

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	王番, 李锐莉, 王文军, 周晓燕, 刘美佑, 赵瑾怡, 文爱东, 王婧雯, 贾艳艳. α-乳香酸通过抑制TLR4介导的炎症通路改善急性肾损伤[J]. 中国药学(英文版), 2023, 32(7): 539-550.
[2]	王昭景, 许青霞, 许京, 徐嵬, 杨秀伟. 补骨脂宁通过激活Nrf2/HO-1并抑制NF-κB信号通路在过氧化氢诱导的HT22细胞和脂多糖诱导的BV2细胞上发挥抗氧化和抗神经炎症作用[J]. 中国药学(英文版), 2023, 32(2): 85-100.
[3]	卢磊, 邱成英, 陈谦. 莲花清瘟颗粒联合头孢噻肟钠对小儿肺炎患儿疗效及血清炎症因子的影响[J]. 中国药学(英文版), 2023, 32(11): 947-953.
[4]	李楷, 唐冰洁, 柴新龙, 平洋, 王丽红, 苏瑾. 唾液酸功能化靶向给药系统: 与唾液酸结合免疫球蛋白样凝集素或选择素受体结合的肿瘤和炎症治疗进展[J]. 中国药学(英文版), 2023, 32(10): 773-795.
[5]	赵雅慧, 赵莉, 赵娟, 卢继业, 田薇, 胡金朋, 苏彬, 付立华, 郭然. 基于生物信息学分析探讨地塞米松通过上调TNFAIP3减轻烟雾吸入性急性肺损伤炎症反应的机制[J]. 中国药学(英文版), 2022, 31(9): 689-697.
[6]	黄嘉欢, 岳玲, 张铭儒, 杨全, 程轩轩. 辣蓼对大肠杆菌性腹泻小鼠炎症因子和细胞色素P450酶表达的影响[J]. 中国药学(英文版), 2022, 31(8): 622-633.
[7]	张婵娟, 胡立坤, 张贺, 漆心怡, 黄健, 刘东. 2-Hydroxycircumdatin C通过抑制TLR4/NF-κB/MAPK和JAK2/STAT3通路对脂多糖诱导BV2小胶质细胞发挥抗炎作用[J]. 中国药学(英文版), 2022, 31(4): 239-249.
[8]	王颖峥, 杨策, 朱翠萍, 赵茜茜, 卢雪花, 苏晓宇, 王英豪. 羌活通过调节P2X3抑制PKC诱导的炎症反应治疗"上肢痹痛"[J]. 中国药学(英文版), 2022, 31(3): 163-175.
[9]	王子翼, 刘晓岩, 朱元军, 刘晔, 张平平, 王银叶. W026B对大鼠全脑缺血再灌注损伤的保护作用[J]. 中国药学(英文版), 2022, 31(2): 108-116.
[10]	吕慧婕, 许拓, 彭俊, 罗刚, 何剑琴, 杨丝丝, 张天成, 奉水东, 凌宏艳. 氢杨梅素改善高脂饮食诱导的肥胖小鼠肝脏脂肪沉积及机制[J]. 中国药学(英文版), 2022, 31(11): 824-839.
[11]	康静婷, 纪超. 加兰他敏调节IL-1β/IL-1RA比率改善炎症微环境的机制探讨[J]. 中国药学(英文版), 2022, 31(10): 773-781.
[12]	蒋雯, 韦亦霖, 温清, 史革鑫, 赵恒利. 美他多辛通过抑制巨噬细胞和中性粒细胞向肝脏浸润缓解急性酒精性肝损伤[J]. 中国药学(英文版), 2022, 31(1): 47-54.
[13]	李睿, 孔燕茹. 利格列汀对初诊2型糖尿病患者炎症因子和动脉硬化的影响[J]. 中国药学(英文版), 2021, 30(8): 692-698.
[14]	洪倩, 王增慧, 杨阳, 高璐, 闫兆. 银杏二萜内酯葡胺注射液通过调控炎症和凋亡信号通路减轻OGD/R诱导的细胞损伤[J]. 中国药学(英文版), 2020, 29(7): 455-469.
[15]	程笑, 杨滢霖, 李伟瀚, 刘漫, 张姗姗, 王月华, 杜冠华. 秦皮甲素减轻脂多糖刺激小鼠急性肾损伤和炎症反应的作用及其机制[J]. 中国药学(英文版), 2020, 29(5): 322-332.