莲花清瘟颗粒联合头孢噻肟钠对小儿肺炎患儿疗效及血清炎症因子的影响

doi:10.5246/jcps.2023.11.076

中国药学(英文版) ›› 2023, Vol. 32 ›› Issue (11): 947-953.DOI: 10.5246/jcps.2023.11.076

莲花清瘟颗粒联合头孢噻肟钠对小儿肺炎患儿疗效及血清炎症因子的影响

卢磊^*(), 邱成英, 陈谦

三亚市人民医院儿科, 海南三亚 572000

收稿日期:2023-06-16 修回日期:2023-07-15 接受日期:2023-08-04 出版日期:2023-12-02 发布日期:2023-12-02
通讯作者: 卢磊
作者简介:
+ Tel.: +86-13902302265, E-mail: Guofei541@163.com

Effect of Lianhua Qingwen granule combined with cefotaxime sodium on the efficacy and serum inflammatory factors in children with pediatric pneumonia

Lei Lu^*(), Chengying Qiu, Qian Chen

Sanya People's Hospital, Sanya 572000, Hainan, China

Received:2023-06-16 Revised:2023-07-15 Accepted:2023-08-04 Online:2023-12-02 Published:2023-12-02
Contact: Lei Lu

摘要/Abstract

摘要：

本研究对莲花清瘟颗粒联合头孢噻肟钠治疗小儿肺炎的疗效及其对血清炎症因子的影响进行了评估。将2020年8月–2022年8月本院小儿肺炎患儿86例随机分成研究组与对照组, 各43例, 对照组单用头孢噻肟钠, 研究组采用莲花清瘟颗粒联合头孢噻肟钠, 比较两组治疗前后总有效率以TNF-α、hs-CRP、IL-6水平; 评估两组体温转归正常时间、喘息好转时间、肺啰音消失时间、咳痰次数减少时间; 对比两组不良反应病例数。结果显示研究组治疗总有效率比对照组高(P < 0.05); TNF-α、hs-CRP、IL-6水平明显低于对照组(P < 0.05); 体温转归正常时间、喘息好转时间、肺啰音消失时间、咳痰次数减少时间均明显短于对照组(P < 0.05); 两组不良反应发生例数差异不明显(P > 0.05)。本研究说明莲花清瘟颗粒联合头孢噻肟钠治疗小儿肺炎有优良效果, 可减轻炎症, 利于病情好转, 同时具有较高的安全性。

关键词: 莲花清瘟, 头孢噻肟钠, 小儿肺炎, 血清炎症因子

Abstract:

In the present study, the efficacy of Lianhua Qingwen granule in combination with cefotaxime sodium for the treatment of pediatric pneumonia in children and its impact on serum inflammatory factors were assessed at our hospital involving 86 children of pediatric pneumonia between August 2020 and August 2022. The cases were randomly divided into a study group and a control group, with 43 cases in each. The control group received cefotaxime sodium alone, while the study group received Lianhua Qingwen granule and cefotaxime sodium. This study aimed to compare the overall effectiveness of the two groups by evaluating the levels of TNF-α, hs-CRP, and IL-6 before and after treatment. Additionally, the time taken for body temperature normalization, improvement of wheezing, disappearance of pulmonary rales, and reduction in coughing sputum were assessed in both groups. Finally, the number of adverse reactions was also compared between the two groups. The study found that the total effectiveness of treatment was significantly higher in the study group compared to the control group (P < 0.05). Moreover, the levels of TNF-α, hs-CRP, and IL-6 were significantly lower in the study group than in the control group (P < 0.05). The study group also demonstrated significantly shorter times for body temperature normalization, improvement of wheezing, disappearance of pulmonary rales, and reduction in coughing sputum compared to the control group (P < 0.05). However, the two groups had no significant difference in the number of adverse reactions (P > 0.05). The combination of Lianhua Qingwen granule and cefotaxime sodium exhibited excellent effects in treating pediatric pneumonia. It effectively reduced inflammation, facilitated disease improvement, and demonstrated a high safety profile.

Key words: Lianhua Qingwen, Cefotaxime sodium, Paediatric pneumonia, Serum inflammatory factor

Supporting:

卢磊, 邱成英, 陈谦. 莲花清瘟颗粒联合头孢噻肟钠对小儿肺炎患儿疗效及血清炎症因子的影响[J]. 中国药学(英文版), 2023, 32(11): 947-953.

Lei Lu, Chengying Qiu, Qian Chen. Effect of Lianhua Qingwen granule combined with cefotaxime sodium on the efficacy and serum inflammatory factors in children with pediatric pneumonia[J]. Journal of Chinese Pharmaceutical Sciences, 2023, 32(11): 947-953.

图/表 4

Table 1. Comparison of clinical effects between the two groups after treatment (n (%)).

Table 2. Comparison of inflammatory mediators between two groups before and after treatment (x ± s).

Table 3. Comparison of symptoms and signs between the two groups after treatment (d, x ± s).

Table 4. Comparison of adverse reactions between two groups during treatment (n (%)).

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莲花清瘟颗粒联合头孢噻肟钠对小儿肺炎患儿疗效及血清炎症因子的影响

Effect of Lianhua Qingwen granule combined with cefotaxime sodium on the efficacy and serum inflammatory factors in children with pediatric pneumonia

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