四逆散提取物对慢性社会竞争失败树鼩抑郁模型的干预作用

doi:10.5246/jcps.2016.06.051

中国药学(英文版) ›› 2016, Vol. 25 ›› Issue (6): 458-465.DOI: 10.5246/jcps.2016.06.051

四逆散提取物对慢性社会竞争失败树鼩抑郁模型的干预作用

韦姗姗¹, 杨和金², 黄加文², 陆雪萍², 彭玲芳², 王庆国^1*

1. 北京中医药大学基础医学院, 北京 100029
2. 云南省药物研究所药物筛选中心, 云南昆明 650111

收稿日期:2016-02-17 修回日期:2016-03-27 出版日期:2016-06-29 发布日期:2016-04-16
通讯作者: Tel.: +86-010-64286727, Fax: +86-010-64213817, E-mail: wangqg8558@sina.com
基金资助:
National Basic Research Program of China (Grant No. 2011CB505100) funded by the Ministry of Science and Technology of China.

Sini Powder extract produces antidepressant-like effects in a chronic social defeat stress model of depression in tree shrews

Shanshan Wei¹, Hejin Yang², Jiawen Huang², Xueping Lu², Lingfang Peng², Qingguo Wang^1*

1. School of Basic Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China
2. Department of Drug Screening, Yunnan Institute of Materia Medica, Kunming, 650111, China

Received:2016-02-17 Revised:2016-03-27 Online:2016-06-29 Published:2016-04-16
Contact: Tel.: +86-010-64286727, Fax: +86-010-64213817, E-mail: wangqg8558@sina.com
Supported by:
National Basic Research Program of China (Grant No. 2011CB505100) funded by the Ministry of Science and Technology of China.

摘要/Abstract

摘要：

四逆散是一个著名的中药复方, 长久以来用于治疗抑郁症。在本研究中, 我们探索了四逆散提取物对于社会竞争失败树鼩抑郁模型的作用及可能机制。动物分为4组, 除了空白组外, 其他动物接受5周的社会竞争失败应激, 后4周分别给予四逆散提取物(3.6 g/kg/d), 氟西汀(15 mg/kg/d)与蒸馏水。结果表明, 四逆散提取物可以逆转慢性应激造成的体重下降和尿/血皮质醇升高;还可以升高海马中去甲肾上腺素的水平。结果证明, 四逆散提取物对于社会竞争失败树鼩抑郁模型的主要症状有治疗作用, 机制可能与缓解应激后高度活跃的下丘脑-皮质-肾上腺轴有关。

关键词: 慢性应激, 树鼩, 社会竞争失败, 四逆散提取物, 下丘脑-垂体-肾上腺轴

Abstract:

Sini Power (SP) is a famed traditional Chinese formula that has long been used to treat depression. Here, we investigated the effects and possible mechanisms of SP extract on an established model of depression: chronic stressed tree shrew, which mimics the human condition of social stress. The animals were divided into 4 groups. Except for the naïve group, the other animalswere subjected to daily social defeat stress for 5 weeks, and during the last 4 weeks treated with SP extract (3.6 g/kg/d), fluoxetine (15 mg/kg/d), and vehicle, respectively. The results showed that SP extract could reverse body weight loss to a certain extent and reduce the levels of urine/serum cortisol that were initially increased by chronic social defeat. In addition, SP extract increased hippocampus norepinephrine concentrations. Our data suggested that SP extract had positive effects on the main depression symptoms in the chronic stressed tree shrew model and that it may be used to help control hypothalamic-pituitary-adrenal axis hyperactivity.

Key words: Chronic stress, Tree shrews, Social defeat, Sini Powder extract, Hypothalamic-pituitary-adrenal axis

中图分类号:

R284

Supporting:

韦姗姗, 杨和金, 黄加文, 陆雪萍, 彭玲芳, 王庆国. 四逆散提取物对慢性社会竞争失败树鼩抑郁模型的干预作用[J]. 中国药学(英文版), 2016, 25(6): 458-465.

Shanshan Wei, Hejin Yang, Jiawen Huang, Xueping Lu, Lingfang Peng, Qingguo Wang. Sini Powder extract produces antidepressant-like effects in a chronic social defeat stress model of depression in tree shrews[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(6): 458-465.

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四逆散提取物对慢性社会竞争失败树鼩抑郁模型的干预作用

Sini Powder extract produces antidepressant-like effects in a chronic social defeat stress model of depression in tree shrews

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