川芎的植物化学、生物活性及质量评价研究综述

doi:10.5246/jcps.2020.11.070

中国药学(英文版) ›› 2020, Vol. 29 ›› Issue (11): 755-779.DOI: 10.5246/jcps.2020.11.070

川芎的植物化学、生物活性及质量评价研究综述

石金徽, 李睿悦, 杨思雨, 张红梅^*

上海中医药大学中药学院, 上海 201203

收稿日期:2020-09-02 修回日期:2020-09-25 出版日期:2020-11-30 发布日期:2020-10-29
通讯作者: Tel.: +86-13916041712; E-mail: naturecolor@163.com
作者简介:Dr Hongmei Zhang, Associate Professor of the institute of pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China, obtained her Ph.D. (Chinese pharmacy) from Shanghai University of Traditional Chinese Medicine in 2008...
基金资助:
The 12th innovation activity plan of undergraduates in the Shanghai University of Traditional Chinese Medicine (Grant No. 2019SHUTCM060), the Natural Science Foundation of Shanghai (Grant No. 19ZR1457700), 2020 New Agricultural Science Research and Reform Practice Project of the Ministry of Education, and 2020 Key Undergraduate Education Reform Project of Shanghai Colleges.

Phytochemistry, biological properties and quality control of Chuanxiong Rhizoma: a review

Jinhui Shi, Ruiyue Li, Siyu Yang, Hongmei Zhang^*

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

Received:2020-09-02 Revised:2020-09-25 Online:2020-11-30 Published:2020-10-29
Contact: Tel.: +86-13916041712; E-mail: naturecolor@163.com
About author:Dr Hongmei Zhang, Associate Professor of the institute of pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China, obtained her Ph.D. (Chinese pharmacy) from Shanghai University of Traditional Chinese Medicine in 2008...
Supported by:
The 12th innovation activity plan of undergraduates in the Shanghai University of Traditional Chinese Medicine (Grant No. 2019SHUTCM060), the Natural Science Foundation of Shanghai (Grant No. 19ZR1457700), 2020 New Agricultural Science Research and Reform Practice Project of the Ministry of Education, and 2020 Key Undergraduate Education Reform Project of Shanghai Colleges.

摘要/Abstract

摘要：

川芎是一味应用广泛的中药, 已有2000年的用药历史。川芎的化学成分由挥发油、苯酞内酯、有机酚酸和多糖等化合物组成。到目前为止, 川芎中共报道有149个化合物, 其中报道的生物活性包括心血管疾病治疗作用、中枢神经系统作用以及抗炎和抗氧化作用, 对炎症因子和凋亡因子的调控是川芎体现这些生物活性的主要机理。川芎质量评价的分析方法有HPLC、GC、UPLC等。本文我们讨论了采收期、生长期、炮制方法和储存对川芎质量的影响。全面的质量评价可以保证川芎的临床应用更加安全、有效。我们收集并整理了过去20年内CNKI、Springer link、ScienceDirect、Wiley和PubMed收载的川芎相关文献, 并提供了有关川芎的最新信息。我们建议将藁本内酯、丁烯基苯酞和总洋川芎内酯作为川芎的质量评价指标。此外, 我们认为土壤条件和炮制方法对川芎质量的影响可以作为未来的一个研究方向。

关键词: 川芎, 植物化学, 生物活性, 质量控制

Abstract:

Chuanxiong Rhizoma is a widely used Chinese herbal medicine in the past 2000 years. Chuanxiong Rhizoma is composed of volatile oils, phthalide lactones, phenolic acids, polysaccharides and other compounds. To date, more than 149 compounds in Chuanxiong Rhizoma have been isolated and identified, and some of them have been reported to possess promising biological properties on cardiovascular and central nervous system disorders besides their anti-cancer and antioxidant effects. Modulation of inflammatory mediators and apoptotic factors are believed to contribute to its bioactivities. Analytical methods, such as HPLC, GC and UPLC, are employed for qualitative evaluation of Chuanxiong Rhizoma. In this work, harvest period, growing habitat, processing method and storage, which can affect the quality of Chuanxiong Rhizoma, were also discussed. Comprehensive quality control methods should be developed to ensure the safety, quality and efficacy use of Chuanxiong Rhizoma. Herein, we collected and analyzed the literature of Chuanxiong Rhizoma published on CNKI, ScienceDirect, Springer link, Wiley and PubMed in past two decades, and up-to-date information of Chuanxiong Rhizoma was provided in this paper. We suggested ligustilide, butylidenephthalide and total senkyunolides as the chemical markers to evaluate the quality of Chuanxiong Rhizoma. Additionally, the influences of soil conditions and processing methods on Chuanxiong Rhizoma as future research perspectives should also be further assessed.

Key words: Chuanxiong Rhizoma (CXR), Phytochemistry, Biological property, Quality control

中图分类号:

R284

Supporting:

石金徽, 李睿悦, 杨思雨, 张红梅. 川芎的植物化学、生物活性及质量评价研究综述[J]. 中国药学(英文版), 2020, 29(11): 755-779.

Jinhui Shi, Ruiyue Li, Siyu Yang, Hongmei Zhang. Phytochemistry, biological properties and quality control of Chuanxiong Rhizoma: a review[J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(11): 755-779.

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川芎的植物化学、生物活性及质量评价研究综述

Phytochemistry, biological properties and quality control of Chuanxiong Rhizoma: a review

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