银杏叶中主要成分的统计学分析

doi:10.5246/jcps.2019.12.080

中国药学(英文版) ›› 2019, Vol. 28 ›› Issue (12): 843-854.DOI: 10.5246/jcps.2019.12.080

银杏叶中主要成分的统计学分析

赵一懿¹, 郭如忆², 殷海利³, 傅欣彤¹, 陈有根¹, 郭洪祝^1*

1. 北京市药品检验所中药成分分析与生物评价北京市重点实验室, 北京 102206
2. 北京理工大学数学与统计学院, 北京 100081
3. 北京中医药大学中药学院, 北京 102488

收稿日期:2019-09-12 修回日期:2019-10-28 出版日期:2019-12-28 发布日期:2019-11-03
通讯作者: Tel.: +86-13911788378, E-mail: guohz@bidc.org.cn
基金资助:
National Administration of Traditional Chinese Medicine Standardization Project (Grant No. ZYBZH-C-HEB-16).

Comparative study on main compounds in Ginkgo biloba L. base on mathematical statistics

Yiyi Zhao¹, Ruyi Guo², Haili Yin³, Xintong Fu¹, Yougen Chen¹, Hongzhu Guo^1*

1. Beijing Institute for Drug Control, Beijing Key Laboratory of Analysis and Evaluation on Chinese Medicine, Beijing 102206, China
2. School of Mathematics and Statistics, Beijing Institute of Technology, Beijing 1000081, China
3. College of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China

Received:2019-09-12 Revised:2019-10-28 Online:2019-12-28 Published:2019-11-03
Contact: Tel.: +86-13911788378, E-mail: guohz@bidc.org.cn
Supported by:
National Administration of Traditional Chinese Medicine Standardization Project (Grant No. ZYBZH-C-HEB-16).

摘要/Abstract

摘要：

利用所建立的银杏叶药材中6种黄酮醇苷、5种萜类内酯、9种有机酚酸类共20个主要成分的含量测定方法, 检测了不同来源银杏叶样品中这些成分的含量。运用统计学方法,分别对数据进行了相关性分析、主成分分析以及线性回归分析,明确了所测成分之间的相关关系,反映质量信息的主要成分组成以及主要成分之间存在的回归关系,最终确定对羟基苯甲酸、儿茶素、KRcG和银杏内酯A 4个特征成分为分析指标,既能反映不同产地、不同树龄银杏叶药材的质量特征,又是相互有内在关联、能够体现银杏叶共性特征的指标成分,简化了质量控制指标,为全面、科学和经济地进行银杏叶整体质量控制提供了依据和可行模式。

关键词: 银杏叶, 多元统计分析, 特征成分, 整体质量控制评价

Abstract:

In this paper, an HPLC-DAD-ELSD method was developed to determine main 20 components of Ginkgo bilobaL. leaves from different ages and sources, including six flavonol glycosides, five terpene lactones and nine organic acids. Using statistics method and establishing relevant mathematics models, the measured data has proceeded correlation analysis, principal component analysis, and regression statistics and the results showed generality and specific characteristics. We defined p-hydroxybenzoicacid, catechinic, KRcG and ginkgolide A as characteristic indexes representing commonness and speciality of Ginkgo biloba L. leaf. The four characteristic indexes can reflect the quality of Ginkgo biloba L. leaf, and the internal relations between them are significant.The contents of other compounds could define the quantity relation with characteristic markers. It simplified the approach of quality control, and provided a basis for quality control of Ginkgo biloba L.

Key words: Ginkgo biloba L., Statistical analysis, Characteristic markers, Holistic quality evaluation

中图分类号:

R284

Supporting:

赵一懿, 郭如忆, 殷海利, 傅欣彤, 陈有根, 郭洪祝. 银杏叶中主要成分的统计学分析[J]. 中国药学(英文版), 2019, 28(12): 843-854.

Yiyi Zhao, Ruyi Guo, Haili Yin, Xintong Fu, Yougen Chen, Hongzhu Guo. Comparative study on main compounds in Ginkgo biloba L. base on mathematical statistics[J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(12): 843-854.

参考文献

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银杏叶中主要成分的统计学分析

Comparative study on main compounds in Ginkgo biloba L. base on mathematical statistics

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