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中国药学(英文版) ›› 2014, Vol. 23 ›› Issue (11): 778-782.DOI: 10.5246/jcps.2014.11.099

• 【研究论文】 • 上一篇    下一篇

岗梅叶的化学成分研究

王超, 李军*, 屠鹏飞**   

  1. 北京大学医学部 药学院 天然药物及仿生药物国家重点实验室,  北京 100191 
  • 收稿日期:2014-05-08 修回日期:2014-05-15 出版日期:2014-11-24 发布日期:2014-06-09
  • 通讯作者: Tel./Fax: 86-10-82805103, 86-10-82802750
  • 基金资助:
    National Key Technology R&D Program “New Drug Innovation” of China (Grant No. 2012ZX09201-201-001, 2012ZX09301002-002-002 and 2012ZX09304-005), and Doctoral Fund of Ministry of Education (Grant No. 20110001130003).

Chemical constituents from the leaves of Ilex asprella (Hook. et Arn.) Champ. ex Benth.

Chao Wang, Jun Li*, Pengfei Tu**   

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
  • Received:2014-05-08 Revised:2014-05-15 Online:2014-11-24 Published:2014-06-09
  • Contact: Tel./Fax: 86-10-82805103, 86-10-82802750
  • Supported by:
    National Key Technology R&D Program “New Drug Innovation” of China (Grant No. 2012ZX09201-201-001, 2012ZX09301002-002-002 and 2012ZX09304-005), and Doctoral Fund of Ministry of Education (Grant No. 20110001130003).

摘要:

研究冬青属植物岗梅叶的化学成分, 通过硅胶柱色谱、Sephadex LH-20柱色谱、反相硅胶柱色谱、制备高效液相色谱等色谱方法分离纯化得到11个化合物, 经多种波谱方法鉴定及与文献对照, 其结构分别为kaempferol-3-O-β-D-6′′-acetylglucopyranoside (1), kaempferol-4'-methylether (2), quercetin (3), quercetin-3-O-glucopyranoside (4), tormentoside (5), suavissimoside R1 (6), 3β,19α-dihydroxyolean-12-ene-24,28-dioicacid-28-O-β-D-glucopyranoside (7), 3-O-β-sulfooxy-19-hydroxyurs-12-ene-28-oic acid (8), coniferin (9), adenoside (10), 1-O-benzyl-α-L-rhamnopyranosyl-(1′′→6)-β-D-glucopyranoside (11)。其中化合物1, 2, 5, 9-11为首次从冬青属植物中分离得到, 化合物3, 4, 6-8为首次从岗梅叶中分离得到。

关键词: 岗梅叶, 黄酮, 含硫三萜, 三萜皂苷, 化学成分

Abstract:

Phytochemical investigation of the leaves of Ilex aspralla (Hook. et Arn.) Champ. ex Benth. led to the isolation of eleven compounds (1-11). By comparison with those reported data in the literatures their structures were identified as kaempferol-3-O-β-D-6′′-acetylglucopyranoside (1), kaempferol-4-methylether (2), quercetin (3), quercetin-3-O-glucopyranoside (4), tormentoside (5), suavissimoside R1 (6), 3β,19α-dihydroxyolean-12-ene-24,28-dioicacid-28-O-β-D-glucopyranoside (7), 3-O-β-sulfooxy-19-hydroxy-urs-12-ene-28-oic acid (8), coniferin (9), adenoside (10), 1-O-benzyl-α-L-rhamnopyranosyl-(1′′→6)-β-D-glucopyranoside (11). Among these, six compounds (1, 2, 5, 9-11) were firstly reported from the genus Ilex, and five compounds (3, 4, 6-8) were isolated for the first time from Ilex aspralla.

Key words: Ilex asprella, Flavonoids, Sulfated triterpenoid, Triterpenoid saponins, Chemical constituents

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