北枳椇子中的黄酮碳苷类成分

doi:10.5246/jcps.2020.11.074

中国药学(英文版) ›› 2020, Vol. 29 ›› Issue (11): 813-818.DOI: 10.5246/jcps.2020.11.074

北枳椇子中的黄酮碳苷类成分

徐方方¹, 孙彪², 张晓琦², 刘博^1*

1. 广州中医药大学第二临床医学院, 广州中药活性成分手性研究重点实验室, 广东广州 510006
2. 暨南大学药学院中药及天然药物研究所, 广东省现代中药工程技术研究中心, 广东广州 510632

收稿日期:2020-08-23 修回日期:2020-09-12 出版日期:2020-11-30 发布日期:2020-09-30
通讯作者: Tel.: +86-20-39318571, E-mail: doctliu@263.net
作者简介:Bo Liu, Ph.D., Professor, the director of Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, and the Principal Investigator of Team of Chemical Research and Structural Optimization based on Chinese Materia Medica, Guangzhou University of Chinese Medicine.
基金资助:
National Natural Science Foundation of China (Grant Nos. 81703379 and U1801287); Key-Area Research and Development Program of Guangdong Province (Grant No. 2020B1111110007); Science and Technology Planning Project of Guangdong Province (Grant No. 2018B020207008); Key Laboratory Program of Guangzhou (Grant 201902010082); the Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine (Grant Nos. YN2016QJ05 and YN2015MS03); Key Project of High-level University Construction of Guangzhou University of Chinese Medicine (Grant No. XK2018019).

Flavonoid C-glycosides from the seeds of Hovenia dulcis Thunb.

Fangfang Xu¹, Biao Sun², Xiaoqi Zhang², Bo Liu^1*

1. Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, the Second Clinical Medicial College, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
2. Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, China

Received:2020-08-23 Revised:2020-09-12 Online:2020-11-30 Published:2020-09-30
Contact: Tel.: +86-20-39318571, E-mail: doctliu@263.net
About author:Bo Liu, Ph.D., Professor, the director of Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine, and the Principal Investigator of Team of Chemical Research and Structural Optimization based on Chinese Materia Medica, Guangzhou University of Chinese Medicine.
Supported by:
National Natural Science Foundation of China (Grant Nos. 81703379 and U1801287); Key-Area Research and Development Program of Guangdong Province (Grant No. 2020B1111110007); Science and Technology Planning Project of Guangdong Province (Grant No. 2018B020207008); Key Laboratory Program of Guangzhou (Grant 201902010082); the Specific Research Fund for TCM Science and Technology of Guangdong Provincial Hospital of Chinese Medicine (Grant Nos. YN2016QJ05 and YN2015MS03); Key Project of High-level University Construction of Guangzhou University of Chinese Medicine (Grant No. XK2018019).

摘要/Abstract

摘要：

本文对北枳椇种子的化学成分进行研究, 从中分离得到10个黄酮碳苷类成分, 通过波谱解析、理化常数及比对文献数据资料进行结构鉴定, 分别为2′′-O-β-D-glucopyranosyl isovitexin (1), spinosin (2), 6′′′-acetyl spinosin (3), 6′′′-p-hydroxycinnamoyl-2′′ O-β-D-glucopyranosyl isovitexin (4), 6′′′-p-hydroxy-cinnamoyl spinosin (5), 6′′′-(E)-feruloyl O-β-D-glucopyranosyl isovitexin (6), isospinosin (7), isovitexin (8), swertisin (9), swertiajaponin (10)。所有化合物均首次从该植物中分离得到。

关键词: 北枳椇, 化学成分, 黄酮碳苷

Abstract:

Ten known flavonoid C-glycosides identified as 2′′-O-β-D-glucopyranosyl isovitexin (1), spinosin (2), 6′′′-acetyl spinosin (3), 6′′′-p-hydroxycinnamoyl-2′′O-β-D-glucopyranosyl isovitexin (4), 6′′′-p-hydroxy-cinnamoyl spinosin (5), 6′′′-(E)-feruloyl O-β-D-glucopyranosyl isovitexin (6), isospinosin (7), isovitexin (8), swertisin (9), swertiajaponin (10) were purified from the seeds of Hovenia dulcis Thunb. Their structures were confirmed by spectroscopic data analysis and comparison with previous literature. All compounds were obtained from H. dulcis for the first time.

Key words: Hovenia dulcis Thunb, Chemical constituents, Flavonoid C-glycosides

中图分类号:

R284

Supporting:

徐方方, 孙彪, 张晓琦, 刘博. 北枳椇子中的黄酮碳苷类成分[J]. 中国药学(英文版), 2020, 29(11): 813-818.

Fangfang Xu, Biao Sun, Xiaoqi Zhang, Bo Liu. Flavonoid C-glycosides from the seeds of Hovenia dulcis Thunb.[J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(11): 813-818.

参考文献

[1] Sinicae Agendae Academiae Sinicae Edita. Flora Reipublicae Popularis Sinicae [M]. Science Press, Beijing. 1982, 48, 88.

[2] Jiang su xin yi yuan. Zhong yao da ci dian. Shanghai People‘s Publishing House, Shanghai. 1977, 667.

[3] Zhang, X.Q.; Xu, F.F.; Wang, L.; Huang, M.Y.; Liu, Z.; Zhang, D.M.; Wang, G.C.; Li, Y.L.; Ye, W.C. Two pairs of new diastereoisomeric flavonolignans from the seeds of Hovenia acerba. Phytochem. Lett. 2012, 5, 292-296.

[4] Xu, F.F. Chemical constituents from the seeds of Hovenia acerba. Jinan University. 2011.

[5] Song, M.; Gao, M.H.; Huang, W.H.; Li, M.M.; Li, H.; Li, Y.L.; Zhang, X.Q.; Ye, W.C. Flavonoids from the seeds of Hovenia acerba and their in vitro antiviral activity. J. Pharm. Biomed. Sci. 2016, 6, 401-409.

[6] Xu, F.F.; Fan, C.L.; Wang, L.; Wang, G.C.; Zhang, X.Q.; Ye, W.C. Chemical constituents from the seeds of Hovenia acerba. J. Jinan Univ. Nat. Sci .Med. 2011, 32, 304-306

[7] Gao, M.H.; He, T.; Zhang, X.Q.; Li, H. Study of flavonoid constituents in the seeds of Hovenia trichocarpa. J. Pharm. Res. 2016, 8, 453-456.

[8] Xu, F.F.; Gao, M.H.; Li, H.; Han, X.D.; Zhang, X.Q.; Li, Y.L.; Guo, D.A.; Liu, B. Three new bisflavonols from the seeds of Hovenia dulcis Thunb. and their anti-RSV activities. Fitoterapia. 2020, 143, 104587.

[9] Markham, K.R.; Tanner, G.J.; Caasi-Lit, M.; Whitecross, M.I.; Nayudu, M.; Mitchell, K.A. Possible protective role for 3′, 4′-dihydroxyflavones induced by enhanced UV-B in a UV-tolerant rice cultivar. Phytochemistry. 1998, 49, 1913-1919.

[10] Zhang, N.L.; Ye, D.K.; Tian, B.R.; Wu, L.J.; Zhang, X.; Long, Q.D.; Sheng, X.C.; Zhang, Y.Y. Chemical Constituents of Hydrocotyle sibthorpioides. J. Guizhou Med. Univ. 2018, 42, 1145-1148

[11] Nakayama, M.; Koshioka, M.; Kondo, T.; Imizu, K. Flavone C-glucosides responsible for yellow pigmentation induced by low temperature in bracts of Zantedeschia aethiopica. Nat. Prod. Commun. 2015, 10, 425-427.

[1]	蒋蕾, 涂渝娇, 代伟华, 袁琳. 云南美登木愈伤组织化学成分的研究[J]. 中国药学(英文版), 2023, 32(4): 283-290.
[2]	谭静玲, 陆娟, 郑国华. 酸藤子化学成分的研究[J]. 中国药学(英文版), 2022, 31(4): 264-269.
[3]	米承能, 梅文莉, 袁靖喆, 龙文兴, 戴好富. 丝沉香化学成分研究[J]. 中国药学(英文版), 2021, 30(6): 505-517.
[4]	吴桐, 杜肖, 王建农, 刘良裕, 杨宇珂. 白英中两个新糖苷生物碱[J]. 中国药学(英文版), 2021, 30(6): 518-523.
[5]	席彩彩, 徐云玲, 冯康, 吴人照, 骆世洪. 马槟榔种子的化学成分研究[J]. 中国药学(英文版), 2021, 30(11): 924-931.
[6]	王慧楠, 张景珍, 崔曰新, 王思雨, 高慧, 张瑶, 王新杰, 杨子烨, 陈梦雨, 王佩华, 张桂梅, 王英姿, 张超. 千金子制霜前后UPLC-Q-TOF/MS化学成分分析研究[J]. 中国药学(英文版), 2020, 29(7): 470-479.
[7]	陈静, 程丽, 王富乾, 汪选斌, 张勇慧, 郝新才. 王瓜化学成分研究[J]. 中国药学(英文版), 2020, 29(6): 431-438.
[8]	宛美琪, 张友波, 杨雁芳, 刘晓艳, 贾凌云, 杨秀伟. 基于UPLC-Q-TOF-MS 液质联用技术对独活中的化学成分进行分析[J]. 中国药学(英文版), 2019, 28(3): 145-159.
[9]	杨小露, 薛兴阳, 林燕, 黄绮韵, 莫毛燕, 王淑美, 孟江. 牡丹皮炭化学成分及其潜在凝血活性研究[J]. 中国药学(英文版), 2018, 27(9): 608-616.
[10]	黄传俊, 刘小锐, 张咪, 别琼, 曾繁荣, 王燕燕, 陈春梅, 朱虎成, 张勇慧. 球毛壳霉中一个新的生物碱类化合物[J]. 中国药学(英文版), 2018, 27(9): 617-622.
[11]	赵一帆, 张东, 梁彩霞, 杨立新, 孙鹏, 马悦, 王坤, 常小强, 杨岚. 维药洋甘菊化学成分研究I[J]. 中国药学(英文版), 2018, 27(5): 324-331.
[12]	李倩, 孙淑仃, 王梅英, 李彩凤, 袁丹, 付宏征. 草乌的化学成分及镇痛活性研究[J]. 中国药学(英文版), 2018, 27(12): 855-863.
[13]	程丽, 陈静, 谭艳, 王富乾, 汪选斌, 薛永波, 郝新才, 张勇慧. 血见愁植物化学成分研究[J]. 中国药学(英文版), 2018, 27(10): 719-723.
[14]	陈新涛, 兰鸿, 郑涛, 董永成, 梁俊, 陈黎. 植物内生真菌团青霉的化学成分研究[J]. 中国药学(英文版), 2017, 26(2): 156-160.
[15]	周颖, 王文光, 屠鹏飞, 姜勇. 四数九里香的化学成分研究[J]. 中国药学(英文版), 2016, 25(3): 201-205.

北枳椇子中的黄酮碳苷类成分

Flavonoid C-glycosides from the seeds of Hovenia dulcis Thunb.

RichHTML

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价