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中国药学(英文版) ›› 2017, Vol. 26 ›› Issue (2): 156-160.DOI: 10.5246/jcps.2017.02.015

• 【简 报】 • 上一篇    下一篇

植物内生真菌团青霉的化学成分研究

陈新涛, 兰鸿, 郑涛, 董永成, 梁俊, 陈黎*   

  1. 十堰市太和医院(湖北医药学院附属医院) 药学部, 湖北 十堰 442000
  • 收稿日期:2016-10-09 修回日期:2016-11-25 出版日期:2017-02-28 发布日期:2016-12-30
  • 通讯作者: Tel.: +86-0719-8801157, E-mail: chenli0201@sina.com
  • 基金资助:

    National Natural Science Foundation of China (Grant Nos. 31370372, 81573316, 31270395, 31570361, and 81202423), the National Science and Technology Project of China (Grant Nos. 2011ZX09102-004 and 2013ZX09103001-020).

Chemical constituents isolated from the endophytic fungus Penicillium commune

Xintao Chen, Hong Lan, Tao Zheng, Yongcheng Dong, Jun Liang, Chen Li*   

  1. Department of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
  • Received:2016-10-09 Revised:2016-11-25 Online:2017-02-28 Published:2016-12-30
  • Contact: Tel.: +86-0719-8801157, E-mail: chenli0201@sina.com
  • Supported by:

    National Natural Science Foundation of China (Grant Nos. 31370372, 81573316, 31270395, 31570361, and 81202423), the National Science and Technology Project of China (Grant Nos. 2011ZX09102-004 and 2013ZX09103001-020).

摘要:

对植物内生真菌团青霉的大米发酵产物进行化学成分研究, 从其乙酸乙酯的提取物中分离得到9个已知化合物。通过波谱手段、理化常数以及与文献对照的方法, 化合物被鉴定为6-acetyl-2α,5-dihydroxy-2-(2-hydroxypropyl)-3α,8-dimethylchroman (1), communol B (2), communol E (3), communol G (4), 4-phenylcarbostyril (5), viridicatol (6), 3-O-methylviridicatin (7), trans-ferulic acid (8), 1,2-benzenediol,4-(2-methoxyethenyl) (9)其中化合物15-9为首次从团青霉的大米发酵产物中首次分离得到。

关键词: 团青霉, 化学成分, 结构鉴定

Abstract:

Phytochemical investigation of the endophytic fungus Penicillium communeled to the isolation of nine known compounds.Based on the spectroscopic and chemical properties, their structures were identified as 6-acetyl-2α,5-dihydroxy-2-(2-hydroxypropyl)-3α,8-dimethylchroman (1), communol B (2), communol E (3), communol G (4), 2-hydroxy-4-phenylquinoline (5), viridicatol (6), 3-O-methylviridicatin (7), trans-ferulic acid (8), 1,2-benzenediol,4-(2-methoxyethenyl) (9). Compounds 1 and 5-9 were isolated from this fungus for the first time.        

Key words: Penicillium commune, Chemical constituents, Structural identification

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