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中国药学(英文版) ›› 2016, Vol. 25 ›› Issue (3): 201-205.DOI: 10.5246/jcps.2016.03.024

• 【研究论文】 • 上一篇    下一篇

四数九里香的化学成分研究

周颖, 王文光, 屠鹏飞, 姜勇*   

  1. 北京大学医学部 药学院 天然药物及仿生药物国家重点实验室, 北京 100191
  • 收稿日期:2015-10-25 修回日期:2015-11-18 出版日期:2016-03-29 发布日期:2015-12-15
  • 通讯作者: Tel.: 86-10-82802719, E-mail: yongjiang@bjmu.edu.cn
  • 基金资助:

    National Science Fund for Excellent Young Scholars (Grant No. 81222051), and National Key Technology R&D Program “New Drug Innovation” of China (Grant Nos. 2012ZX09301002-002-002 and 2012ZX09304-005).

Chemical constituents from Murraya tetramera Huang

Ying Zhou, Wenguang Wang, Pengfei Tu, Yong Jiang*   

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
  • Received:2015-10-25 Revised:2015-11-18 Online:2016-03-29 Published:2015-12-15
  • Contact: Tel.: 86-10-82802719, E-mail: yongjiang@bjmu.edu.cn
  • Supported by:

    National Science Fund for Excellent Young Scholars (Grant No. 81222051), and National Key Technology R&D Program “New Drug Innovation” of China (Grant Nos. 2012ZX09301002-002-002 and 2012ZX09304-005).

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摘要：

对四数九里香的地上部位进行了化学成分研究。运用硅胶和Sephadex LH-20柱色谱及制备HPLC和TLC等多种分离方法进行分离纯化, 共分离得到9个化学成分, 通过NMR和MS数据分析, 并结合文献对比, 鉴定其结构分别为3,3'-[oxybis(methylene)]bis(9-methoxy-9H-carbazole) (1), murrastifoline B (2), murrayaquinone A (3), 2,4-二甲氧基苯酚 (4), 1,2-二甲氧基-4-硝基苯(5), 间甲基苯甲醚(6), 丁香树脂酚葡萄糖苷(7), β-谷甾醇(8), 3-甲氧基-4-羟基反式苯丙烯酸正十八醇酯(9)。化合物4–6和9为首次从九里香属植物中分离得到, 化合物2–9为该种植物中首次分离得到。

关键词: 芸香科, 四数九里香, 化学成分

Abstract:

The aim of this study is to perform a phytochemical investigation of the aerial parts of Murraya tetramera Huang. Nine compounds wereisolated by silica gel and Sephadex LH-20 chromatography, together with preparative TLC and HPLC methods. By analysis of the MS and NMR spectroscopic data and comparison with those in literature, these nine compounds were identified as 3,3'-[oxybis(methylene)]bis(9-methoxy-9H-carbazole) (1), murrastifoline B (2), murrayaquinone A(3), 2,4-dimethoxyphenol (4), 1,2-dimethoxy-4-nitrobenzene (5), 3-methylanisole (6), (–)-syringaresinol-4-O-β-D-glucopyranoside (7), β-sitosterol (8), and octadecanyl-3-methoxy-4-hydroxylbenzeneacrylate (9), respectively. Among them, compounds 4–6 and 9 were described from the genus Murraya for the first time, and compounds 2–9were isolated from M. tetramera for the first time.

Key words: Rutaceae, Murraya tetramera, Chemical constituents

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