王瓜化学成分研究

doi:10.5246/jcps.2020.06.041

中国药学(英文版) ›› 2020, Vol. 29 ›› Issue (6): 431-438.DOI: 10.5246/jcps.2020.06.041

王瓜化学成分研究

陈静¹⁺, 程丽¹⁺, 王富乾³, 汪选斌¹, 张勇慧^2*, 郝新才^1*

1. 湖北医药学院附属人民医院中医科, 湖北十堰 442008
2. 华中科技大学同济医学院药学院, 湖北省天然药物化学与资源评价重点实验室, 湖北武汉 430030
3. 武汉市第一医院药学部, 湖北武汉 430022

收稿日期:2019-09-15 修回日期:2019-11-12 出版日期:2020-06-30 发布日期:2019-12-19
通讯作者: Tel.: +86-71-98891124; +86-27-83692311, E-mail: zhangyh@mails.tjmu.edu.cn; hxc_smile@163.com
基金资助:
Hubei Provincial Outstanding Young and Middle-aged Science and Technology Innovation Team Project (Grant No. T201813).

Chemical constituents from Trichosanthes cucumeroides

Jing Chen¹⁺, Li Cheng¹⁺, Fuqian Wang³, Xuanbin Wang¹, Yonghui Zhang^2*, Xincai Hao^1*

1. Deptment of Traditional Chinese Medicine, Renmin Hospital, Hubei University of Medicine, Shiyan 442008, China
2. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
3. Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, China

Received:2019-09-15 Revised:2019-11-12 Online:2020-06-30 Published:2019-12-19
Contact: Tel.: +86-71-98891124; +86-27-83692311, E-mail: zhangyh@mails.tjmu.edu.cn; hxc_smile@163.com
Supported by:
Hubei Provincial Outstanding Young and Middle-aged Science and Technology Innovation Team Project (Grant No. T201813).

摘要/Abstract

摘要：

本文对葫芦科植物王瓜化学成分进行了研究,分离得到1个新化合物, 9个已知化合物。通过波谱解析、理化常数及比对文献数据资料进行结构鉴定,分别为3β-[(E)-caffeoyloxy]-D:C-friedooleana-7,9(11)-dien-29-oic acid (1), cucurbitacin B (2), 23,24-dihydrocucurbitacin B (3), 23,24-dihydrocu-curbitacin D (4), cucurbitacin D (5), cucurbalsaminol A (6), 3-epi-isocucurbitacin D (7), curbitacin G (8), cucurbitacin J (9) and cucurbitacin I (10), 所有化合物均首次从该植物中分离得到。

关键词: 王瓜, 化学成分, 三萜化合物, 结构解析

Abstract:

One new triterpenoid, 3β-[(E)-caffeoyloxy]-D:C-friedooleana-7,9(11)-dien-29-oic acid (1) and nine known triterpenoidsidentified as cucurbitacin B (2), 23,24-dihydrocucurbitacin B (3), 23,24-dihydrocu-curbitacin D (4), cucurbitacin D (5), cucurbalsaminol A (6), 3-epi-isocucurbitacin D (7), curbitacin G (8), cucurbitacin J (9) and cucurbitacin I (10)were purified from Trichosanthes cucumeroides. Their structures were confirmed by spectroscopic data analysis and comparison with previous literature. All compounds were obtained from T.cucumeroides for the first time.

Key words: Trichosanthes cucumeroides, Chemical constituents, Triterpenoid, Structural identification

中图分类号:

R284

Supporting:

Figure S1. IRspectrum of compound 1.

Figure S2. HRESIMSspectrum of compound 1.

Figure S3. ¹H-NMR spectrum of compound 1 (400MHz CD₃OD).

Figure S4. ¹³C-NMR spectrum of compound 1 (400MHz CD₃OD).

Figure S5. DEPTspectrum of compound 1.

Figure S6. HSQC spectrum of compound 1.

Figure S7. HMBC spectrum of compound 1.

Figure S8. ¹H–¹H COSY spectrum of compound 1.

Figure S9. NOESY spectrum of compound 1.

陈静, 程丽, 王富乾, 汪选斌, 张勇慧, 郝新才. 王瓜化学成分研究[J]. 中国药学(英文版), 2020, 29(6): 431-438.

Jing Chen, Li Cheng, Fuqian Wang, Xuanbin Wang, Yonghui Zhang, Xincai Hao. Chemical constituents from Trichosanthes cucumeroides[J]. Journal of Chinese Pharmaceutical Sciences, 2020, 29(6): 431-438.

参考文献

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王瓜化学成分研究

Chemical constituents from Trichosanthes cucumeroides

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