丝沉香化学成分研究

doi:10.5246/jcps.2021.06.039

中国药学(英文版) ›› 2021, Vol. 30 ›› Issue (6): 505-517.DOI: 10.5246/jcps.2021.06.039

丝沉香化学成分研究

米承能¹^,²^,³, 梅文莉¹^,², 袁靖喆¹^,²^,³, 龙文兴³, 戴好富¹^,²^,^*()

1. 中国热带农业科学院热带生物技术研究所海南省沉香工程技术研究中心, 海南海口 571101
2. 海南省黎药资源天然产物研究与利用重点实验室, 海南海口 571101
3. 海南大学热带林学院, 海南海口 570228

收稿日期:2020-11-23 修回日期:2021-01-12 接受日期:2021-03-13 出版日期:2021-06-29 发布日期:2021-06-29
通讯作者: 戴好富
作者简介:
+ Tel./Fax: +86-898-66988061, E-mail: daihaofu@itbb.org.cn
基金资助:
National Key Research & Development Program of China (Grant No. 2018YFC1706400); National Natural Science Foundation of China (Grant No. 31870668); China Agriculture Research System (Grant No. CARS-21).

Chemical constituents from agarwood of Aquilaria filaria

Chengneng Mi¹^,²^,³, Wenli Mei¹^,², Jingzhe Yuan¹^,²^,³, Wenxing Long³, Haofu Dai¹^,²^,^*()

1 Hainan Engineering Research Center of Agarwood, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China
2 Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Haikou 571101, China
3 Institute of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China

Received:2020-11-23 Revised:2021-01-12 Accepted:2021-03-13 Online:2021-06-29 Published:2021-06-29
Contact: Haofu Dai

摘要/Abstract

摘要：

为研究丝沉香的化学成分, 本研究采用硅胶、葡聚糖凝胶LH-20、半制备高效液相色谱等多种柱层析技术从丝沉香的乙醇提取物分离得到26个化合物, 运用波谱学方法分别鉴定为β-谷甾酮(1)、24α-乙基-3α-胆甾醇(2)、麦角-4,6,8(14),22-四烯-3-酮(3)、丝石竹皂苷元(4)、常春藤皂苷元(5)、17αH-trisnorhopanone (6)、羽扇豆醇(7)、木栓酮(8)、(?)-表丁香树脂醇(9)、丁香树脂醇(10)、5-羟基-7,4′-二甲氧基黄酮(11)、5,4′-二羟基-7,3′-二甲氧基黄酮(12)、2′-羟基-4,3′,6′,4′′-四甲氧基对三联苯(13)、scopularide A (14)、覆盆子酮(15)、姜油酮(16)、松柏醛(17)、7-羟基-6-甲氧基香豆素(18)、乙酰香子兰酮(19)、异香草醛(20)、香草醛(21)、对羟基苯甲醛(22)、对羟基苯甲酸(23)、原儿茶酸(24)、香草酸(25)和没食子酸-3-甲基醚(26)。以上化合物均为首次从丝沉香中分离鉴定, 化合物2, 4, 6, 7, 9, 10, 13?15, 17?20, 22, 24和26为首次从沉香和其基源植物中报道。

关键词: 丝沉香, 化学成分, 三萜, 甾体

Abstract:

Investigations on the chemical constituents from the ethanol extract of the agarwood originating from Aquilaria filaria led to the isolation of 26 compounds by column chromatography, including silica gel, Sephadex LH-20, and semi-preparative high-performance liquid chromatography. Their structures were determined to be β-sitostenone (1), 24α-ethyl-cholestan-3α-ol (2), ergosta-4,6,8(14), 22-tetraene-3-one (3), gypsogenin (4), hederagenin (5), 17αH-trisnorhopanone (6), lupeol (7), friedelin (8), (?)-episyringaresinol (9), (?)-syringaresinol (10), 5-hydroxy-7,4′-dimethoxyflavone (11), 5,4'-dihydroxy-7,3′-dimethoxyflavone (12), 2′-hydroxy-4,3′,6′,4′′-tetramethoxy-p-terphenyl (13), scopularide A (14), 4-(4-hydroxyphenyl)butan-2-one (15), zingerone (16), coniferaldehyde (17), scopoletin (18), acetovanillon (19), isovanillin (20), vanillin (21), p-hydroxybenzaldehyde (22), p-hydroxybenzoic acid (23), protocatechuic acid (24), vanillic acid (25) and 4,5-dihydroxy-3-methoxybenzoic acid (26) by using spectroscopic techniques. All compounds were isolated from agarwood of A. filaria for the first time, and this was also the first report about the isolation of compounds 2, 4, 6, 7, 9, 10, 13?15, 17?20, 22, 24 and 26 from agarwood and Aquilaria plants.

Key words: Agarwood of Aquilaria filaria, Chemical constituents, Triterpene, Steroid

Supporting:

米承能, 梅文莉, 袁靖喆, 龙文兴, 戴好富. 丝沉香化学成分研究[J]. 中国药学(英文版), 2021, 30(6): 505-517.

Chengneng Mi, Wenli Mei, Jingzhe Yuan, Wenxing Long, Haofu Dai. Chemical constituents from agarwood of Aquilaria filaria[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(6): 505-517.

图/表 1

参考文献 48

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丝沉香化学成分研究

Chemical constituents from agarwood of Aquilaria filaria

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