白英中两个新糖苷生物碱

doi:10.5246/jcps.2021.06.040

中国药学(英文版) ›› 2021, Vol. 30 ›› Issue (6): 518-523.DOI: 10.5246/jcps.2021.06.040

白英中两个新糖苷生物碱

吴桐, 杜肖, 王建农^*(), 刘良裕, 杨宇珂

中国中医科学院西苑医院基础医学研究所, 北京 100091

收稿日期:2020-11-06 修回日期:2020-12-23 接受日期:2021-01-20 出版日期:2021-06-29 发布日期:2021-06-29
通讯作者: 王建农
作者简介:
+ Tel.: +86-10-62835620 , E-mail: wangjiannong2008@sina.com
基金资助:
National Natural Science Foundation of China (Grant No. 81872989), the Program of G20 Project Support Guarantee (Grant No. Z151100003815026) and the National Major New Drugs Innovation Projects (Grant No. 2009ZX09103-402).

Two new glycoalkaloids from Solanum lyratum Thunb.

Tong Wu, Xiao Du, Jiannong Wang^*(), Liangyu Liu, Yuke Yang

Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China

Received:2020-11-06 Revised:2020-12-23 Accepted:2021-01-20 Online:2021-06-29 Published:2021-06-29
Contact: Jiannong Wang

摘要/Abstract

摘要：

对中药白英的生物碱类成分进行研究。采用ODS、硅胶柱层析和高效液相色谱相结合的方法对生物碱进行分离纯化。通过UHPLC-ESI-Q-TOF-MS、1D和2D NMR鉴定了7个生物碱类化合物, 分别为15β-ethoxy-(3β,5α,25R)-16,23-epoxy-23,24-imino-cholestan-16,20,23(N)-triene-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (1), 15β-hydroxyl-(3β,25R)-16,23-epoxy-23,24-imino-cholestan-5,16,20,23(N)-tetraene-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactop-yranoside (2), Solalyraine A (3), Solalyraine B (4), 16,23-epoxy-22,26-imino-cholest-22(N),23,25(26)-trien-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (5), N-(4-amino-butyl)-3-(3-hydroxy-4-methoxy-phenyl)-E-acrylamide (6) and magnoflorine (7)。其中化合物1和2为文献未报道的两个新的甾体糖苷类生物碱, 化合物7首次从白英中分离得到。

关键词: 白英, 甾体糖苷生物碱, 化学成分, 结构鉴定

Abstract:

To study the alkaloids of Solanum lyratum Thunb. ODS and silica gel column chromatography combined with HPLC were used to separate and purify the alkaloids. Seven alkaloids were identified via UHPLC-ESI-Q-TOF-MS, 1D and 2D NMR, respectively 15β-ethoxy-(3β,5α,25R)-16,23-epoxy-23,24-imino-cholestan-16,20,23(N)-triene-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactopyran-oside (1), 15β-hydroxyl-(3β,25R)-16,23-epoxy-23,24-imino-cholestan-5,16,20, 23(N)-tetraene-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactop-yranoside (2), Solalyraine A (3), Solalyraine B (4), 16,23-epoxy-22,26-imino-cholest-22(N),23,25(26)-trien-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (5), N-(4-amino-butyl)-3-(3-hydroxy-4-methoxy-phenyl)-E-acrylamide (6) and magnoflorine (7). Among them, compounds 1 and 2 were two new steroidal glycoalkaloids that has not been reported in the literature, and compound 7 was isolated from S. lyratum for the first time.

Key words: Solanum lyratum Thunb., Steroidal glycoalkaloids, Chemical constituents, Structure identification

Supporting:

吴桐, 杜肖, 王建农, 刘良裕, 杨宇珂. 白英中两个新糖苷生物碱[J]. 中国药学(英文版), 2021, 30(6): 518-523.

Tong Wu, Xiao Du, Jiannong Wang, Liangyu Liu, Yuke Yang. Two new glycoalkaloids from Solanum lyratum Thunb.[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(6): 518-523.

图/表 3

参考文献 15

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白英中两个新糖苷生物碱

Two new glycoalkaloids from Solanum lyratum Thunb.

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