白英中木脂素类化学成分研究

doi:10.5246/jcps.2018.04.030

中国药学(英文版) ›› 2018, Vol. 27 ›› Issue (4): 289-294.DOI: 10.5246/jcps.2018.04.030

• 【简报】 • 上一篇

白英中木脂素类化学成分研究

徐云玲^1,2,3, 徐雅娟³, 石浩霞^1,2,3, 刘悦^3*, 徐暾海^1,2*

1. 北京中医药大学中药学院, 北京 100029
2. 中医养生学教育部重点实验室, 北京 100029
3. 吉林省中医药科学院中药药效物质基础实验室, 吉林长春 130012

收稿日期:2018-01-13 修回日期:2018-02-23 出版日期:2018-04-30 发布日期:2018-03-15
通讯作者: Tel.: +86-010-64286935, E-mail: thxu@163.com
基金资助:
Science and Technology Department Plan of Jilin Province, China (Grant No. 20160101341JC and 20160622010JC).

Lignanoids from Solanum lyratum

Yunling Xu^1,2,3, Yajuan Xu³, Haoxia Shi^1,2,3, Yue Liu^3*, Tunhai Xu^1,2*

1. Academy of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
2. Health Cultivation Laboratory of Ministry of Education, Beijing 100029, China
3. Key Laboratory of Effective Substances of Traditional Chinese Medicine, Jilin Academy of Chinese Medicine Sciences, Changchun 130012, China

Received:2018-01-13 Revised:2018-02-23 Online:2018-04-30 Published:2018-03-15
Contact: Tel.: +86-010-64286935, E-mail: thxu@163.com
Supported by:
Science and Technology Department Plan of Jilin Province, China (Grant No. 20160101341JC and 20160622010JC).

摘要/Abstract

摘要：

对中药白英的木脂素类成分进行深入研究。通过正相硅胶柱色谱、Sephadex LH-20凝胶柱色谱及制备高效液相色谱技术进行分离纯化, 利用理化性质及波谱分析技术(¹H NMR、¹³C NMR)共鉴定了13个化合物, 分别为紫丁香苷 (1)、(+)-异落叶松脂素 (2)、(+)-丁香脂醇 (3)、leptolepisol D (4)、(–)-开环异裂松脂素(5)、(–)-表丁香脂素 (6)、aviculin (7)、浙贝素 (8)、刺五加酮 (9)、(–)-(7′S,8S,8′R)-4,4′-二羟基-3,3′,5,5′-四甲氧基7′,9-单环氧木脂素-9′-醇-7-酮 (10)、(+)-松脂醇 (11)、(+)-松脂素 (12)、(+)-杜仲树脂酚 (13)。这些化合物均为首次从白英中分离得到。

关键词: 白英, 木脂素类, 丁香脂醇, 松脂素

Abstract:

In the present study, we aimed to investigate the chemical constituents from Solanum lyratum.The constituents were separated by column chromatography on silica gel, Sephadex LH-20 and preparative HPLC. Their structures were elucidated by spectroscopic means. A total of 13 compounds were isolated fromS. lyratumand identified as syringin (1), (+)-isolariciresinol (2), (+)-syringaresinol (3), leptolepisol D (4),(–)-secoisolariciresinol (5), (–)-epi-syringaresinol (6),aviculin(7), zhebeiresinol(8), ciwujiatone(9), (–)-(7′S,8S,8′R)-4,4′-dihydroxy-3,3′,5,5′-tetramethoxy-7′,9-epoxylignan-9′-ol-7-one(10),(+)-lariciresinol(11), (+)-pinoresinol (12) and (+)-medioresinol (13). All the compounds were isolated from S. lyratumfor the first time.

Key words: Solanum lyratum, Lignanoids, Syringaresinol, Lariciresinol

中图分类号:

R284

Supporting:

徐云玲, 徐雅娟, 石浩霞, 刘悦, 徐暾海. 白英中木脂素类化学成分研究[J]. 中国药学(英文版), 2018, 27(4): 289-294.

Yunling Xu, Yajuan Xu, Haoxia Shi, Yue Liu, Tunhai Xu. Lignanoids from Solanum lyratum[J]. Journal of Chinese Pharmaceutical Sciences, 2018, 27(4): 289-294.

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白英中木脂素类化学成分研究

Lignanoids from Solanum lyratum

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