不同来源中药黄芪的质量评价

不同来源中药黄芪的质量评价

刘靖, 陈虎彪^*, 杜新刚, 赵中振, 王邠, 赵玉英, 易涛

1. 香港浸会大学中医药学院, 香港

2. 北京大学天然药物及仿生药物国家重点实验室; 药学院天然药物学系, 北京 100191

收稿日期:2008-12-06 修回日期:2009-02-10 出版日期:2009-03-15 发布日期:2009-03-15
通讯作者: 陈虎彪*

Quality evaluation of Radix Astragali from different sources in China

Jing Liu, Hu-Biao Chen^*, Xin-Gang Du, Zhong-Zhen Zhao, Bin Wang, Yu-Ying Zhao, Tao Yi

1. School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China

2. The State Key Laboratory of Natural and Biomimetic Drugs; Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

Received:2008-12-06 Revised:2009-02-10 Online:2009-03-15 Published:2009-03-15
Contact: Hu-Biao Chen*

摘要/Abstract

摘要： 中药黄芪为常用补气药, 市场上黄芪药材来源复杂, 质量参差不齐。本研究针对56份不同种源、不同栽培基地、不同年限、不同采收季节、不同商业规格的黄芪药材, 采用高效液相色谱法, 测定了其中的有效成分(毛蕊异黄酮、毛蕊异黄酮苷、芒柄花素、芒柄花苷及黄芪甲苷) 的含量, 对其进行质量评价。实验结果表明不同来源的黄芪药材的异黄酮类化合物及黄芪甲苷的含量存在明显的差异, 为黄芪药材的选用提供了一定的依据。

关键词: 黄芪, 质量评价, HPLC, 异黄酮类化合物, 黄芪甲苷

Abstract: Radix Astragali (Huangqi) is one of the most valuable traditional Chinese medicinal herbs. It is used in the traditional Chinese medicine to reinforce ‘qi’, and it has immunostimulant, tonic, and antioxidant activities. There are many different sources of Huangqi in the market. In this study, the quality of Huangqi was evaluated by the measurement of four flavonoids, calycosin-7-O-β-D-glucopyranoside, ononin, calycosin and formononetin with HPLC-UV, as well as astragaloside IV with HPLC-ELSD. Samples included different plant species, different places of cultivation, different ages of plants, different seasons of collection and different commercial specifications. The results showed that the contents of isoflavonoids and astragaloside IV varied significantly in different sources. Our study provided useful information for the quality evaluation of Radix Astragali.

Key words: Radix Astragali, Radix Astragali, Quality evaluation, Quality evaluation, High performance liquid chromatography, High performance liquid chromatography, Isoflavonoids, Isoflavonoids, Astragaloside IV, Astragaloside IV

中图分类号:

R282.2

Supporting: Foundation item: Faculty Research Grant of Hong Kong Baptist University (FRG/06-07/II-24).
^*Corresponding author. Tel.: 852-34112060; fax: 852-34112461

刘靖, 陈虎彪^*, 杜新刚, 赵中振, 王邠, 赵玉英, 易涛

不同来源中药黄芪的质量评价

[J]. .

Jing Liu, Hu-Biao Chen^*, Xin-Gang Du, Zhong-Zhen Zhao, Bin Wang, Yu-Ying Zhao, Tao Yi

Quality evaluation of Radix Astragali from different sources in China

[J]. .

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