三叶鬼针草中的黄酮类成分

doi:10.5246/jcps.2011.05.066

三叶鬼针草中的黄酮类成分

田昕, 周思祥, 魏荷琳, 胡南, 代志, 刘志刚, 韩正洲, 屠鹏飞^*

1. 北京大学医学部天然药物及仿生药物国家重点实验室, 北京 100191
2. 华润三九医药股份有限公司, 深圳 518110

收稿日期:2011-05-04 修回日期:2011-08-15 出版日期:2011-09-20 发布日期:2011-09-20
通讯作者: 屠鹏飞*

Flavonoids from the herb of Bidens pilosa L.

Xin Tian, Si-Xiang Zhou, He-Lin Wei, Nan Hu, Zhi Dai, Zhi-Gang Liu, Zheng-Zhou Han, Peng-Fei Tu^*

1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China
2. China Resources Sanjiu Medical & Pharmaceutical Co. Ltd., Shenzhen 518110, China

Received:2011-05-04 Revised:2011-08-15 Online:2011-09-20 Published:2011-09-20
Contact: Peng-Fei Tu*

摘要/Abstract

摘要：

研究了三叶鬼针草Bidens pilosa L.全草的化学成分。利用各种色谱和波谱方法分离并鉴定了13个黄酮类化合物, 分别为: 2'-hydroxy-4,4'-dimethoxy-chalcone (1), isoliquiritigenin (2), 3,2',4'-trihydroxy-4-methoxy-chalcone (3), licochalcone A (4), 4'-O-β-D-glucopyranosyl-2',3-dihydroxy-4-methoxy-chalcone (5), butein (6), apigenin (7), luteolin (8), diosmetin (9), chrysoeriol (10), 3,5,6,7,3',4',5'-heptamethoxyflavone (11), 7-O-β-D-glucopyranosyl-5,3'-dihydroxy-3,6,4'-trimethoxyflavone (12), sulfuretin (13)。化合物1-5, 9, 11均为首次从鬼针草属植物中分离得到。

关键词: 三叶鬼针草, 鬼针草属, 菊科, 化学成分, 黄酮类化合物, 查尔酮, 黄酮

Abstract:

Chemical constituents of the whole herb of Bidens pilosa L. were investigated. By using various column chromatography (CC) and spectroscopic methods, 13 flavonoids were isolated and identified as follows: 2'-hydroxy-4,4'-dimethoxy-chalcone (1), isoliquiritigenin (2), 3,2',4'-trihydroxy-4-methoxy-chalcone (3), licochalcone A (4), 4'-O-β-D-glucopyranosyl-2',3-dihydroxy-4-methoxy-chalcone (5), butein (6), apigenin (7), luteolin (8), diosmetin (9), chrysoeriol (10), 3,5,6,7,3',4',5'-heptamethoxyflavone (11), 7-O-β-D-glucopyranosyl-5,3'-dihydroxy-3,6,4'-trimethoxyflavone (12), and sulfuretin (13). Compounds 1-5, 9, 11 were obtained from the genus Bidens for the first time.

Key words: Bidens pilosa L., Bidens, Compositae, Chemical constituents, Flavonoids, Chalcone, Flavone

中图分类号:

R284.2

Supporting:

Foundation items: Research Platform for Quality Standard of TCM and Information System Building (Grant No. 2009ZX09308-04) and National S&T Major Project-Created Major New Drugs Projects (Grant No. 2009ZX09311-004).
^*Corresponding author. Tel.: 86-10-82802750

田昕, 周思祥, 魏荷琳, 胡南, 代志, 刘志刚, 韩正洲, 屠鹏飞^*. 三叶鬼针草中的黄酮类成分[J]. , DOI: 10.5246/jcps.2011.05.066.

Xin Tian, Si-Xiang Zhou, He-Lin Wei, Nan Hu, Zhi Dai, Zhi-Gang Liu, Zheng-Zhou Han, Peng-Fei Tu^* . Flavonoids from the herb of Bidens pilosa L. [J]. , DOI: 10.5246/jcps.2011.05.066.

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