丹参及其同属植物的水溶性活性成分

• 综述 • 下一篇

丹参及其同属植物的水溶性活性成分

黎莲娘

中国医学科学院中国协和医科大学药物研究所, 北京 100050

收稿日期:1996-10-14 修回日期:1997-01-03 出版日期:1997-06-15 发布日期:1997-06-15

Water Soluble Active Components of Salvia miltiorrhiza and Related Plants

Lian-Niang Li

Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050

Received:1996-10-14 Revised:1997-01-03 Online:1997-06-15 Published:1997-06-15

摘要/Abstract

摘要： 经化学研究, 自9种鼠尾草属植物中获得各种多酚酸类化合物, 其中11个成分为缩酚酸类化合物, 其化学结构是由R-(+)-β-(3,4-二羟基苯基)乳酸和咖啡酸的衍生物或咖啡酸的二聚物酯化而成的。除了迷迭香酸和紫草酸以外, 此类缩酚酸未曾从其它植物中分离得到, 因此命名其为丹酚酸A, B, C, D, E, H, I, J和异丹酚酸C。丹酚酸F, G和甘肃鼠尾草酸A为新的多酚酸类化合物。药理实验结果说明这些多酚酸具有很强的抗氧化活性。对这些化合物的心、脑损伤保护作用亦进行了研究。

关键词: 丹参, 缩酚酸, 丹酚酸, 抗氧化, 生物活性

Abstract: Chemical studies on nine Salvia species yielded various polyphenolic acids. Eleven of them were depsides of R-(+)-β-(3,4-dihydroxyphenyl) lactic acid and a caffeic acid derivative or caffeic acid dimer. Except the two known depsides, rosmarinic acid and lithospermic acid, this type of depsides has not been isolated from other plant materials before, so they were named salvianolic acid A, B, C, D, E, H, I, J and isosalvianolic acid C. Salvianolic acid F, G and przewalskinic acid A were new polyphenolic acids. Pharmacological studies of these polyphenolic acids showed potent antioxidant activities. The effects of these components in protecting against brain and heart damage have been studied.

Key words: Salvia miltiorrhiza, Depsides, Salvianolic acid, Antioxidant, Biological activities

Supporting:

黎莲娘. 丹参及其同属植物的水溶性活性成分[J]. .

Lian-Niang Li. Water Soluble Active Components of Salvia miltiorrhiza and Related Plants[J]. .

参考文献

[1] Huang SL. Botany of Salvia miltiorrhiza.. In: Xu RS. ed. Danshen-Biology and Its A pplication.. Beijing: Science Press, 1990, 23-25.
[2] Li LN, Tan R, Chen WM. Planta Med, 1984, 50: 227.
[3] Ai CB, Li LN. J Nat Prod, 1988, 51: 145.
[4] Ai CB, Li LN. Planta Med, 1992, 58: 197.
[5] Ai CB, Li LN. Chinese Chem Lett, 1996, 7: 427.
[6] Ai CB, Li LN. Chinese Chem Lett, 1991, 2: 17.
[7] Zhang HJ, Li LN. Chinese Chem Lett, 1993, 4: 501.
[8] Zhang HJ, Li LN. Planta Med, 1994, 60: 70.
[9] Ai CB, Deng QH, Song WZ, Li LN, Phytochemistry, 1994, 37: 907.
[10] Qian TX, Li LN. Phytochemistry, 1992, 31: 1068.
[11] Li J, Li LN, Song WZ. Chinese Traditional and Herbal Drugs, 1994, 24: 347.
[12] Lu XZ, Xu WH, Shen JX, Naoki H. Chinese Chem Lett 1991, 2: 301.
[13] Zhao LM, He WY, Liang XT, Li LN. Chinese Chem Lett, 1996,7: 449.
[14] Zhao LM, Liang XT, Li LN. Phytochemistry, 1996, 42: 899.
[15] Qian TX, Yan ZH, Li LN. J Chin Pharm Sci, 1993, 2: 148.
[16] Gottlieb OR. Phytochemistry, 1972, 11: 1537.
[17] Liu GT, Zhang TM, Wang BE, Wang YW. Biochem Pharmacol, 1992, 42: 147.
[18] Xu LN, Li DY, Tian JY. Proc. 3rd. Nat Symp of Activating Blood Circulation and Removing Stasis Research: Oct. 1990, Lushan, p198.
[19] Lin TJ, Liu GT. Chin J Pharmacol Toxicol, 1991, 5: 276.
[20] Lin TJ, Liu GT, Liu Y, Xu GZ. Free Radical Biology & Medicine, 1992, 12: 347.
[21] Zou ZW, Xu LN, Tian JY. Acta Pharm Sin, 1993, 28: 241.
[22] Yu WG, Xu LN. Acta Pharm Sin, 1994, 29: 412.
[23] Du GH, Qiu Y, Zhang JT. Acta Pharm Sin, 1995, 30: 731.
[24] Du GH, Zhang JT. Acta Pharm Sin, 1995, 30: 184.
[25] Du GH, Qiu Y, Tian YE, Zhang J T. Acta Pharm Sin, 1995, 30: 561.
[26] Murakami S, Kijima H, Isobe Y, Muramatsu M., Aihara H, Otomo S, Li LN, Ai CB. Planta Med, 1990, 56: 360.
[27] Tanaka T, Morimoto S, Nonaka G, Nishioka I, Yokozawa T, Chung HY, Oura H, Chem Pharm Bull, 1989, 37: 340.
[28] Kohda H, Takeda O, Tanaka S, Yamasaki K, Yamashita A, Kurokawa T, Ishibashi S. Chem Pharm Bull, 1989, 37: 1287.