酸藤子化学成分的研究

doi:10.5246/jcps.2022.04.023

中国药学(英文版) ›› 2022, Vol. 31 ›› Issue (4): 264-269.DOI: 10.5246/jcps.2022.04.023

酸藤子化学成分的研究

谭静玲¹^,³, 陆娟²^,^*(), 郑国华³

1. 湖北省药品监督检验研究院, 湖北省药品质量检测与控制工程技术研究中心, 湖北武汉 430075
2. 襄阳市公共检验检测中心, 湖北襄阳 44110
3. 湖北中医药大学药学院, 湖北武汉 436065

收稿日期:2021-11-12 修回日期:2021-12-08 接受日期:2021-12-25 出版日期:2022-04-30 发布日期:2022-04-30
通讯作者: 陆娟
作者简介:
+ Tel.: +86-27-87705260, E-mail: circa2008@sina.com

Chemical constituents from the stem of Embelia laeta

Jingling Tan¹^,³, Juan Lu²^,^*(), Guohua Zheng³

1 Hubei Engineering Research Center for Drug Qualltiy Control, Hubei Institute for Drug Control, Wuhan 430075, China
2 Xiangyang Public Inspection and Testing Center, Xiangyang 441104, China
3 School of Pharmacy, Hubei Universtiy of Chinese Medicine, Wuhan 430065, China

Received:2021-11-12 Revised:2021-12-08 Accepted:2021-12-25 Online:2022-04-30 Published:2022-04-30
Contact: Juan Lu

摘要/Abstract

摘要：

本研究运用硅胶、C₁₈反相、MCI柱色谱及半制备HPLC等多种色谱分离方法从酸藤子中分离得到13个化合物。通过NMR和MS数据分析, 并结合文献数据对比等方法, 鉴定了它们的结构, 包括(6R,9R)-1-Oxo-α-ionol-9-O-β-D-goucopyranoside (1), (+)-Pinoresinol (2), Leptolepisol D (3), 山柰酚(4), 山柰酚-3-α-L-鼠李糖苷 (5), Kaempferol-3-β-D-(6-O-trans-p-coumaroyl) glucopyranoside (6), Bis(2-ethylhexyl) phthalate (7), 邻苯二甲酸二丁酯 (8), 咖啡酸甲酯 (9), 芥子醛 (10), Coniferaldehyde (11), 咖啡酸 (12), 5-羟甲基糠醛 (13)。所有化合物均为首次从该植物中分离得到。

关键词: 酸藤子, 化学成分, 结构鉴定

Abstract:

In the present study, we aimed to investigate the chemical constituents from Embelia laeta. The constituents were separated by various column chromatography, including silica gel, ODS gel, MCI gel, Sephadex LH-20, and semipreparative HPLC. Their structures were elucidated by spectroscopic means. A total of 13 compounds were isolated from E. laeta and identified as (6R,9R)-1-Oxo-α-ionol-9-O-β-D-goucopyranoside (1), (+)-Pinoresinol (2), Leptolepisol D (3), Kaempferol (4), Kaempferol-3-α-L-Ramnopyranoside (5), Kaempferol-3-β-D-(6-O-trans-p-coumaroyl) glucopyranoside (6), Bis(2-ethylhexyl) phthalate (7), 2-Benzenedicarboxylic diisobutyl ester (8), Caffeic acid methyl ester (9), Paldehyde (10), Coniferaldehyde (11), Caffeic acid (12) and 5-Hydroxymethyl furfural (13), respectively. All the compounds were isolated from E. laeta for the first time.

Key words: Embelia laeta, Chemical constituents, Structural identification

Supporting:

谭静玲, 陆娟, 郑国华. 酸藤子化学成分的研究[J]. 中国药学(英文版), 2022, 31(4): 264-269.

Jingling Tan, Juan Lu, Guohua Zheng. Chemical constituents from the stem of Embelia laeta[J]. Journal of Chinese Pharmaceutical Sciences, 2022, 31(4): 264-269.

图/表 1

参考文献 16

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酸藤子化学成分的研究

Chemical constituents from the stem of Embelia laeta

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