马槟榔种子的化学成分研究

doi:10.5246/jcps.2021.11.080

中国药学(英文版) ›› 2021, Vol. 30 ›› Issue (11): 924-931.DOI: 10.5246/jcps.2021.11.080

马槟榔种子的化学成分研究

席彩彩¹^,²^,³, 徐云玲¹, 冯康⁴, 吴人照¹^,^*(), 骆世洪³^,⁵^,^*()

1. 浙江省中医药研究院, 浙江杭州 310007
2. 浙江大学生命科学学院生物系统稳态与保护教育部实验室, 浙江杭州 310058
3. 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室, 云南昆明 650201
4. 浙江特殊教育职业学院, 浙江杭州 310023
5. 沈阳农业大学生物科学与技术学院, 辽宁沈阳 110866

收稿日期:2021-06-10 修回日期:2021-07-09 接受日期:2021-08-31 出版日期:2021-11-28 发布日期:2021-11-28
通讯作者: 吴人照, 骆世洪
作者简介:
+ Tel.: +86-571-88849081, E-mail: wufeng03@126.com
+ Tel.: +86-24-88487163, E-mail: luoshihong@syau.edu.cn
基金资助:
National Science and Technology Major Project (Major New Drug Development, Grant No. 2016ZX09101069).

Chemical constituents from the seeds of Capparis masaikai

Caicai Xi¹^,²^,³, Yunling Xu¹, Kang Feng⁴, Renzhao Wu¹^,^*(), Shihong Luo³^,⁵^,^*()

1 Zhejiang Academy of Traditional Chinese Medicine, Hangzhou 310007, China
2 MOE Laboratory of Biosystem Homeostasis and Protection, College of Life Sciences, Zhejiang University, Hangzhou 310058, China
3 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
4 Zhejiang Vocational College of Special Education, Hangzhou 310023, China
5 College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang 110866, China

Received:2021-06-10 Revised:2021-07-09 Accepted:2021-08-31 Online:2021-11-28 Published:2021-11-28
Contact: Renzhao Wu, Shihong Luo

摘要/Abstract

摘要：

采用大孔树脂、硅胶、凝胶、MCI等柱层析及RP-HPLC等色谱方法对马槟榔Capparis masaikai种子提取物反复进行分离纯化, 根据化合物的理化性质和波谱数据进行结构鉴定, 得到化合物21个, 分别鉴定为: 恶唑烷硫酮 (1)、琥珀酰亚胺 (2)、邻苯二酚 (3)、硫单质 (4)、乙醇胺 (5)、3-羟基丙腈 (6)、L-阿拉伯糖 (7)、甘油 (8)、drummondol (9)、spionoside B (10)、腺苷 (11)、(6S,9S)-长寿花糖苷 (12)、松柏苷 (13)、紫丁香苷 (14)、顺式丁香苷 (15)、二氢丁香苷 (16)、3-吲哚甲酸 (17)、吲哚-3-甲酸-β-D-吡喃葡萄糖苷 (18)、6-hydroxyindole-3-carboxylic acid β-D-glucopyranosyl ester (19)、亚油酸单甘油酯 (20)和油酸甘油三酯 (21)。其中化合物2–10和12–21为首次从该植物中分离得到。

关键词: 马槟榔, 化学成分, 分离纯化, 结构鉴定

Abstract:

A total of 21 compounds were isolated from the seeds of Capparis masaikai and identified as oxazolidine-2-thione (1), succinimide (2), catechol (3), octathiocane (4), monoethanolamine (5), 3-hydroxypropanenitrile (6), L-arabinose (7), 1,2,3-propanetriol (8), drummondol (9), spionoside B (10), adenosine (11), corchoionoside C (12), coniferin (13), syringin (14), cis-syringin (15), dihydrosyringin (16), indole-3-carboxylic acid (17), β-D-glucopyranosyl indole-3-carboxylic acid (18), 6-hydroxyindole-3-carboxylic acid β-D-glucopyranosyl ester (19), linoleis monoglyceride (20), and triolein (21). Their structures were identified based on physicochemical property and spectroscopic analysis, including MS, NMR, and single-crystal X-ray crystallographic data. Compounds 2–10 and 12–21 were isolated from C. masaikai for the first time.

Key words: Capparis masaikai, Chemical constituents, Isolation, Identification

Supporting:

席彩彩, 徐云玲, 冯康, 吴人照, 骆世洪. 马槟榔种子的化学成分研究[J]. 中国药学(英文版), 2021, 30(11): 924-931.

Caicai Xi, Yunling Xu, Kang Feng, Renzhao Wu, Shihong Luo. Chemical constituents from the seeds of Capparis masaikai[J]. Journal of Chinese Pharmaceutical Sciences, 2021, 30(11): 924-931.

图/表 1

参考文献 28

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马槟榔种子的化学成分研究

Chemical constituents from the seeds of Capparis masaikai

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