长毛籽远志根的化学成分研究

doi:10.5246/jcps.2014.10.092

中国药学(英文版) ›› 2014, Vol. 23 ›› Issue (10): 723-730.DOI: 10.5246/jcps.2014.10.092

长毛籽远志根的化学成分研究

周雨虹¹, 郭强², 姜勇¹, 屠鹏飞^1,2*

1. 北京大学医学部天然药物及仿生药物国家重点实验室, 北京 100191
2. 北京中医药大学中药现代研究中心, 北京 100029

收稿日期:2014-01-13 修回日期:2014-02-10 出版日期:2014-10-31 发布日期:2014-02-15
通讯作者: Tel.: 86-10-82802750, Fax: 86-10-82802859
基金资助:
The National Key Technology R&D Program “New Drug Innovation” of China (Grant No. 2012ZX09301002-002-002, 2012ZX09304-005), special funds for scientific research on traditional Chinese medicine (Grant No. 201307002), and National Science Fund for Excellent Young Scholars (Grant No. 81222051).
a These authors contribute to the paper equally.

Chemical constituents from the roots of Polygala wattersii Hance

Yuhong Zhou¹, Qiang Guo², Yong Jiang¹, Pengfei Tu^1,2*

1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China
2. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China

Received:2014-01-13 Revised:2014-02-10 Online:2014-10-31 Published:2014-02-15
Contact: Tel.: 86-10-82802750, Fax: 86-10-82802859
Supported by:
The National Key Technology R&D Program “New Drug Innovation” of China (Grant No. 2012ZX09301002-002-002, 2012ZX09304-005), special funds for scientific research on traditional Chinese medicine (Grant No. 201307002), and National Science Fund for Excellent Young Scholars (Grant No. 81222051).
a These authors contribute to the paper equally.

摘要/Abstract

摘要：

为长毛籽远志Polygala wattersii 的质量控制和进一步的开发提供科学依据, 我们对它的根进行了系统的化学成分研究。利用硅胶、Sephadex LH-20、制备薄层色谱及半制备液相等多种色谱分离技术进行分离和纯化, 应用EI-MS、ESI-MS、¹H NMR及¹³C NMR等现代波谱技术并与文献相对照等方法鉴定化合物的结构。共从长毛籽远志根中分离鉴定了23个化合物, 包括11个口山酮类: 1,3-二羟基口山酮(1), 1-羟基-3-甲氧基口山酮 (2), 1,3-二羟基-2-甲氧基口山酮 (3), 1,3,7-三羟基-2-甲氧基口山酮 (4), 1,3,6-三羟基-2,7-二甲氧基口山酮 (5), 1,6,7-三羟基-2,3-二甲氧基口山酮 (6), 1,7-二羟基-2,3-亚甲二氧基口山酮 (7), 1,7-二甲氧基口山酮 (8), 1,2,3-三甲氧基口山酮 (9), 1-甲氧基-2,3-亚甲二氧基口山酮(10), 6-羟基-1-甲氧基-2,3-亚甲二氧基口山酮 (11); 9个糖酯类: 3'-O-阿魏酰基-6-O-乙酰蔗糖 (12), arillatose B (13), sibricose A₅(14), sibricose A₆ (15), 3',6-二-O-芥子酰基蔗糖 (16),tenufoliside A (17), 3'-O-3,4,5-三甲氧基肉桂酰基-6-O-对甲氧基苯甲酰基蔗糖 (18), glomeratose A (19), 1-O-对香豆酰基葡萄糖 (20); 两个三萜皂苷类: bayogenin-3-O-glucoside (21) 和tenufolin (22)及1个苯丙素类: 芥子酸(23)。其中, 化合物2和12为首次从远志属中分离得到, 除化合物16外其它所有化合物均为首次从该种植物中分离得到。

关键词: 远志科, 长毛籽远志, 化学成分, 口山酮, 糖酯

Abstract:

To investigate the chemical constituents of the roots of Polygala wattersiiHance,the separation and purification were performed by solvent extraction and repeated column chromatography (CC) on silica gel, Sephadex LH-20 and macroporous resin D101, preparative TLC and semi-preparative HPLC. The structures were identified by spectroscopic analysis and comparison of their¹H and ¹³C NMR data with those reported in literatures. Twenty-three known compounds, including eleven xanthones (1-11), nine sugar esters (12–20), two triterpenoid saponins (21 and 22) and one phenylpropanoid (23) were isolated and their structures were identified as 1,3-dihydroxyxanthone (1), 1-hydroxy-3-methoxyxanthone (2), 1,3-dihydroxy-2-methoxyxanthone (3), 1,3,7-trihydroxy-2-methoxyxanthone (4), 1,3,6-trihydroxy-2,7-dimethoxyxanthone (5), 1,6,7-trihydroxy-2,3-dimethoxyxanthone (6), 1,7-dihydroxy-2,3-methylenedioxyxanthone (7), 1,7-dimethoxyxanthone (8), 1,2,3-trimethoxyxanthone (9), 1-methoxy-2,3-methylenedioxyxanthone (10), 6-hydroxy-1-methoxy-2,3-methylenedioxyxanthone (11), 3'-O-feruloyl-6-O-acetyl sucrose (12), arillatose B (13), sibricose A₅(14), sibricose A₆ (15), 3',6-di-O-sinapoyl sucrose (16), tenufoliside A (17), 3'-O-3,4,5-trimethoxycinnamoyl-6-O-p-methoxybenzoyl sucrose (18), glomeratose A (19), 1-O-p-coumaroyl-D-glucopyranose (20), bayogenin-3-O-glucoside (21), tenufolin (22), and sinapic acid (23). Among them, compounds 2 and 12 were obtained from genus Polygala for the first time, and except compound 16, all others were isolated from this species for the first time.

Key words: Polygalaceae, Polygala wattersii Hance, Chemical constituents, Xanthones, Sugar esters

中图分类号:

R284

Supporting:

周雨虹, 郭强, 姜勇, 屠鹏飞. 长毛籽远志根的化学成分研究[J]. 中国药学(英文版), 2014, 23(10): 723-730.

Yuhong Zhou, Qiang Guo, Yong Jiang, Pengfei Tu . Chemical constituents from the roots of Polygala wattersii Hance[J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(10): 723-730.

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长毛籽远志根的化学成分研究

Chemical constituents from the roots of Polygala wattersii Hance

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