维药洋甘菊化学成分研究I

doi:10.5246/jcps.2018.05.033

中国药学(英文版) ›› 2018, Vol. 27 ›› Issue (5): 324-331.DOI: 10.5246/jcps.2018.05.033

维药洋甘菊化学成分研究I

赵一帆, 张东^*, 梁彩霞, 杨立新, 孙鹏, 马悦, 王坤, 常小强, 杨岚^*

中国中医科学院中药研究所, 北京 100700

收稿日期:2018-01-16 修回日期:2018-03-18 出版日期:2018-05-31 发布日期:2018-04-23
通讯作者: Tel.: +86-010-64014347; +86-13810123884, E-mail: ylan_66@163.com; 13810123884@163.com

Chemical constituents from Matricaria chamomilla L. (I)

Yifan Zhao, Dong Zhang^*, Caixia Liang, Lixin Yang, Peng Sun, Yue Ma, Kun Wang, Xiaoqiang Chang, Lan Yang^*

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

Received:2018-01-16 Revised:2018-03-18 Online:2018-05-31 Published:2018-04-23
Contact: Tel.: +86-010-64014347; +86-13810123884, E-mail: ylan_66@163.com; 13810123884@163.com

摘要/Abstract

摘要：

研究洋甘菊MatricariachamomillaL.的化学成分。采用硅胶、凝胶、制备液相等色谱方法进行分离纯化,并利用核磁(NMR)、质谱(MS)等现代波谱技术对化合物的结构进行鉴定。从维药洋甘菊中共鉴定出18个酚类化合物,分别鉴定为芹菜素(1), 高良姜素(2), 木犀草素(3), 山奈酚(4), 槲皮素(5), 高车前素(6), 6-甲氧基山奈酚(7), 泽兰叶黄素(8), 3-甲氧基槲皮素(9), 3,4′-二甲氧基-5,7-二羟基黄酮(10), 5,7,4′-三羟基-3,6-二甲氧基黄酮(11), bracteoside(12), 7-O-(β-D-glucopyranosyl)-galactin(13), 异绿原酸B(14), 异绿原酸C(15), 对羟基苯甲酸(16), 5-十五烷基间苯二酚(17), 东莨菪内酯(18)。其中,化合物1–13为黄酮类化合物。化合物2、6–17是首次从母菊属植物中分离得到。

关键词: 洋甘菊, 全草, 化学成分, 黄酮类

Abstract:

In the present study, we aimed to perform a phytochemical investigation of the whole herb of Matricaria chamomilla L., a Uygur herbal medicine. A total of 18 phenolic compounds were isolated by silica gel and Sephadex LH-20 chromatography, together with preparative HPLC methods. By analysis of the MS and NMR spectroscopic data and comparison with those in literature, these 18 compounds were identified as apigenin (1), galangin (2), luteolin (3), kempherol (4), quercetin (5), hispidulin (6), 6-methoxykaempferol (7), eupafolin (8), 3-methylquercetin (9), ermanin (10), 5,7,4′-trihydroxy-3,6-dimethoxyflavonone (11),bracteoside (12), 7-O-(β-D-glucopyranosyl)-galactin (13), isochlorogenic acid B (14), isochlorogenic acid C (15), 4-hydroxybenzoic acid (16), 5-pentadecylbenzene-1,3-diol (17) and scopoletin (18). Among them, compounds 1–13 were identified as flavonoids. Compounds 2 and 6–17 were isolated from both the plant and the Matricaria genus for the first time.

Key words: Matricaria chamomilla L., The whole herb, Constituents, Flavonoids

中图分类号:

R284

Supporting:

赵一帆, 张东, 梁彩霞, 杨立新, 孙鹏, 马悦, 王坤, 常小强, 杨岚. 维药洋甘菊化学成分研究I[J]. 中国药学(英文版), 2018, 27(5): 324-331.

Yifan Zhao, Dong Zhang, Caixia Liang, Lixin Yang, Peng Sun, Yue Ma, Kun Wang, Xiaoqiang Chang, Lan Yang. Chemical constituents from Matricaria chamomilla L. (I)[J]. Journal of Chinese Pharmaceutical Sciences, 2018, 27(5): 324-331.

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维药洋甘菊化学成分研究I

Chemical constituents from Matricaria chamomilla L. (I)

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