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红树植物海漆中的酚苷类化合物

李泳新, 于霞, 于善江, 马爱英, 邓志威, 林文翰*   

  1. 1. 北京大学医学部 天然药物及仿生药物国家重点实验室, 北京100191
    2. 中国生物技术发展中心, 北京 100036
    3. 北京师范大学 分析测试中心, 北京 100072
  • 收稿日期:2010-03-25 修回日期:2010-06-10 出版日期:2010-07-15 发布日期:2010-07-15
  • 通讯作者: 林文翰*

Phenolic glucopyranosides from the Chinese mangrove plant Excoecaria agallocha L.

Yong-Xin Li, Xia Yu, Shan-Jiang Yu, Ai-Ying Ma, Zhi-Wei Deng, Wen-Han Lin*   

  1. 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
    2. China National Center for Biotechnology Development, Beijing 100036, China
    3. Analytical and Testing Center, Beijing Normal University, Beijing, 100072
  • Received:2010-03-25 Revised:2010-06-10 Online:2010-07-15 Published:2010-07-15
  • Contact: Wen-Han Lin*

摘要: 应用色谱技术, 从红树植物海漆Excoecaria agallocha L.中获得11种酚苷类化合物。其中, 化合物 1 为新的酚苷类化合物, 命名为1-(3,5-dimethoxy-4-hydroxybenzyl)-6-O-galloyl-1-O-β-D-glucopyranoside (1)。已知糖苷分别鉴定为3,5-dimethoxy-4-hydroxybenzyl-1-O-β-D-glucopyranoside (2), hydrangeifolin I (3), (2-methoxy-5-hydroxymethyl-phenyl)-1-O-β-D-(6-O-galloyl) glucopyranoside (4), (3,5-dimethoxy-4-hydroxyphenyl)-1-O-β-D-(6-O-galloyl) glucopyranoside (5), 3-methoxy-4-hydroxyphenyl 1-O-β-D-(6-O-galloyl) glucopyranoside (6), 3,4,5-trimethoxyphenyl-(6-O-galloyl)-1-O-β-D-glucopyranoside (7), koaburaside (8), koaburaside monomethyl ether (9), cuneatasides D (10), (E)-isosyringin (11)。化合物 2-6, 8-11 为首次从大戟科海漆属中分得。新化合物的结构经理化性质及1D, 2D NMR方法确定, 已知化合物的结构通过波谱分析及与文献数据比较得以确定。

关键词: 海漆, 酚苷, 化学成分, 红树植物

Abstract: Chemical examination of a Chinese mangrove plant Excoecaria agallocha L. led to the isolations of a new glucoside named 1-(3,5-dimethoxy-4-hydroxybenzyl)-6-O-galloyl-1-O-β-D-glucopyranoside (1), together with 10 known glycosides including 3,5-dimethoxy-4-hydroxybenzyl-1-O-β-D-glucopyranoside (2), hydrangeifolin I (3), (2-methoxy-5-hydroxymethyl-phenyl)-1-O-β-D-(6-O-galloyl) glucopyranoside (4), (3,5-dimethoxy-4-hydroxyphenyl)-1-O-β-D-(6-O-galloyl) glucopyranoside (5), 3-methoxy-4-hydroxyphenyl 1-O-β-D-(6-O-galloyl) glucopyranoside (6), 3,4,5-trimethoxyphenyl-(6-O-galloyl)-O-β-D-glucopyranoside (7), koaburaside (8), koaburaside monomethyl ether (9), cuneatasides D (10), and (E)-isosyringin (11). Their structures were determined through the extensive spectroscopic analysis and comparison with the reported data in literature. Compounds 2-6, 8-11 were isolated from the genus Excoecaria for the first time.

Key words: Excoecaria agallocha, Phenolic glucopyranoside, Chemical components, Mangrove plant

中图分类号: 

Supporting: Foundation items: National Hi-Tech Development Project (863 Project) (Grant No. 2006DFA31100, 2007AA09Z448, 2008AA09Z405), NSFC (No. 30930109), National Key Innovation Project (2009ZX09501-014, DYXM-115-02-2-09).
*Corresponding author. Tel.: 86-10-82806188; fax: 86-10-82802724