红树植物海芒果中一个新的单萜

红树植物海芒果中一个新的单萜

于霞¹, 徐岷涓¹, 邓志威², 林文翰^1*

1. 北京大学天然药物及仿生药物国家重点实验室, 北京 100191
2. 北京师范大学分析测试中心, 北京 100072

收稿日期:2009-05-27 修回日期:2009-08-10 出版日期:2009-09-15 发布日期:2009-09-15
通讯作者: 林文翰*

A new linear monoterpene from the Chinese mangrove plant Cerbera manghas L.

Xia Yu¹, Min-Juan Xu¹, Zhi-Wei Deng², Wen-Han Lin^1*

1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
2. Analytical and Testing Center, Beijing Normal University, Beijing 100072, China

Received:2009-05-27 Revised:2009-08-10 Online:2009-09-15 Published:2009-09-15
Contact: Wen-Han Lin*

摘要/Abstract

摘要：

对红树植物海芒果中的化学成分进行研究。采用多种色谱手段进行分离纯化, 得到单体化合物, 通过理化性质及1D, 2D NMR方法确定了化合物结构。分离得到1个新的单萜类化合物, 命名为 (2E,6S)-8-hydroxy-2-hydroxymethyl-6-methyl-2-octenoic acid (1)。10个已知化合物鉴定为cerbinal (2), cerberidol (3), 2α,3β,24-trihydroxyolea-12en-28oic acid (4), 4,4',9,7'-tetrahydroxy-3,3'-dimethoxy-7,9'-epoxylignan (5), (-)-olovil (6), (+)-cycloolivil (7), naringenin-7-glucoside (8), aromadendrin (9), naringenine (10) 和 (+)-dihydroquercetin (11)。化合物4, 5, 8–11为首次从该植物中分得。

关键词: 海芒果, 单萜, 化学成分, 红树植物

Abstract:

The current study aimed to investigate the chemical components of the Chinese mangrove plant Cerbera manghas L., collected in Hainan Island. Repeated column chromatography was performed for the isolation and purification. Compounds were identified by the analysis of their 1D and 2D NMR data as well as IR and MS spectral data. A new linear monoterpene, named (2E,6S)-8-hydroxy-2-hydroxymethyl-6-methyl-2-octenoic acid (1), together with cerbinal (2), cerberidol (3), 2α,3β,24-trihydroxyolea-12en-28oic acid (4), 4,4',9,7'-tetrahydroxy-3,3'-dimethoxy-7,9'-epoxylignan (5), (-)-olovil (6), (+)-cycloolivil (7), naringenin-7-glucoside (8), aromadendrin (9), naringenine (10), and (+)-dihydroquercetin (11) were isolated from the EtOH and CH2Cl2 extracts. Compounds 4, 5, 8-11 were isolated from this plant for the first time.

Key words: Cerbera manghas L., Cerbera manghas L., Monoterpene, Monoterpene, Chemical components, Chemical components, Mangrove plant, Mangrove plant

中图分类号:

R931.77

Supporting:

Foundation items: NSFC (Grant No. 30672607), the National 863Hi-Tech Projects (Grant No. 2006AA09Z446, 2006DFA31100), China Uni-PhD Base Project (Grant No. 20060001149).
^*Corresponding author. Tel.: 86-10-82806188; fax: 86-10-82802724; e-mail: whlin@bjmu.edu.cn

于霞¹, 徐岷涓¹, 邓志威², 林文翰^1*. 红树植物海芒果中一个新的单萜[J]. .

Xia Yu¹, Min-Juan Xu¹, Zhi-Wei Deng², Wen-Han Lin^1* . A new linear monoterpene from the Chinese mangrove plant Cerbera manghas L. [J]. .

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