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吴茱萸化学成分的研究

杨秀伟*, 滕杰   

  1. 1.北京大学药学院 天然药物及仿生药物国家重点实验室, 北京 100083;
    2.天津医科大学药学院, 天津 300072
  • 收稿日期:2006-10-24 修回日期:2007-02-10 出版日期:2007-03-15 发布日期:2007-03-15
  • 通讯作者: 杨秀伟*

Chemical constituents of the unripe fruits of Evodia rutaecarpa

Xiu-Wei Yang*, Jie Teng

  

  1. 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China;
    2. School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin 300072, China
  • Received:2006-10-24 Revised:2007-02-10 Online:2007-03-15 Published:2007-03-15
  • Contact: Xiu-Wei Yang*

摘要: 目的 研究中药吴茱萸化学成分, 为其质量评价提供科学依据。方法 通过硅胶柱色谱法分离纯化化合物,谱学方法鉴定其结构。结果 分离鉴定了16个化合物,分别为:吴茱萸碱(1), 吴茱萸次碱(2), β-谷甾醇(3), 异鼠李黄素(4), 吴茱萸内酯醇(5), 槲皮素(6), 柠檬苦素(7), 吴茱萸新碱A(8), 吴茱萸内酯素(9), 石虎柠檬素A(10), 吴茱萸新碱B(11), 吴茱萸果酰胺-I(12), 胡萝卜苷(13), 反式咖啡酸甲酯(14), 去氢吴茱萸碱(15)和蔗糖(16)结论 化合物461014系首次从吴茱萸中分离得到。

关键词: 芸香科, 芸香科, 芸香科, 吴茱萸, 吴茱萸, 吴茱萸, 黄酮类, 黄酮类, 黄酮类, 柠檬苦素类, 柠檬苦素类, 柠檬苦素类, 苯丙素类, 苯丙素类, 苯丙素类

Abstract:

Aim To investigate the chemical constituents of the unripe fruits of Evodia rutaecarpa (Juss.) Benth. and provide a scien-tific basis for its quality control. Methods The compounds were isolated by silica gel column chromatography and identified by spec-tral analysis. Results Sixteen compounds were identified as evodiamine(1), rutaecarpine(2), β-sitosterol(3), isorhamnetin(4), evodol(5), quercetin(6), limonin(7), wuzhuyurutine A(8), evodirutaenin(9), shihulimonin A(10), wuzhuyurutine B(11), wuchuyuamide I(12), daucosterol(13), trans-caffeic acid methylate(14), dehydroevodiamine(15) and sucrose(16). Conclusion Compounds 4, 6, 10 and 14 were isolated from the title plant for the first time.

Key words: Rutaceae, Rutaceae, Evodia rutaecarpa Juss. Benth., Evodia rutaecarpa Juss. Benth., Flavonoids, Flavonoids, Limonoids, Limonoids, Phenylpropenoids, Phenylpropenoids

中图分类号: 

Supporting:

Foundation item: The National High-Tech 863 Project (No.2002AA22Z343C) and Beijing Sciences Foundation (No.Z0004105040311).
*Corresponding author. Tel.: 86-10-82805106