虎眼万年青球茎中的化学成分

虎眼万年青球茎中的化学成分

唐于平, 俞飚^*, 胡杰, 吴弢, 惠永正

中国科学院上海有机化学研究所生命有机化学国家重点实验室, 上海 200032

收稿日期:2001-08-08 修回日期:2001-10-29 出版日期:2001-12-15 发布日期:2001-12-15
通讯作者: 俞飚*

The Chemical Constituents from the Bulbs of Ornithogalum caudatum

Tang Yuping, Yu Biao^*, Hu Jie, Wu Tao, Hui Yongzheng

State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Received:2001-08-08 Revised:2001-10-29 Online:2001-12-15 Published:2001-12-15
Contact: Yu Biao*

摘要/Abstract

摘要： 从虎眼万年青(Ornithogalum caudatum) 的球茎中, 用色谱方法分离得到1个新天然产物1和26个已知化合物2~27, 它们的结构经波谱法和化学方法确定为n-butyl pyroglumate(1), 十九醇(2), 二十醇(3), 二十二烷酸(4), β-谷甾醇(5), 豆甾醇(6), 二十六烷酸1-甘油酯(7), 儿茶酚(8), 对乙氧基苯甲酸(9), p-香豆酸(10), 原儿茶酸(11), 熊果酸(12), 白桦脂酸(13), 富马酸(14), 琥珀酸(15), 尿嘧啶(16), 黄嘌呤(17), 槲皮素(18), 山柰酚(19), 异鼠李素(20), 腺嘌呤核苷(21), 胡萝卜甙(22), 豆甾醇3-O-β-D-葡萄糖甙(23), 槲皮素3-O-β-D-葡萄糖甙(24), 山柰酚3-O-β-D-葡萄糖甙(25), 芦丁(26), 山柰酚3-O-β-芸香糖甙(27)。其中除化合物5外, 其它成分均首次从虎眼万年青属植物中分离得到。

关键词: 虎眼万年青, 球茎, 化学成分

Abstract: A new natural product (1) together with 26 know compounds were isolated from the Bulbs of Ornithogalum caudatum. Their structures were established on the basis of spectral analyses as n-butyl pyroglutamate (1), nonadecyl alcohol(2), eicosanol(3), behenic acid(4), β-sitosterol(5), stigmasterol(6), glycerol 1-monocerotate(7), pyrocatechol(8), p-ethoxybenzoic acid(9), p-coumarinic acid(10), protocatechuric acid(11), ursolic acid(12), betulinic acid(13), fumaric acid(14), succinic acid(15), uracil(16), xanthine(17), quercetin(18), kaempferol (19), isorham-netin(20), adenosine(21), daucosterol(22), stigmasterol 3-O-β-D-glucopyranoside(23), quercetin 3-O-β-D-glucopyra-noside(24), kaempferol 3-O-β-D-glucopyranoside(25), rutin(26), and kaempferol 3-O-β-rutinoside(27). All of them, except compound 5, were isolated from this plant for the first time.

Key words: Ornithogalum caudatum, Ornithogalum caudatum, Bulb, Bulb, Chemical constituent, Chemical constituent

Supporting:

^*To whom correspondence should be addressed. Tel: (021) 64163300-1407. Fax: (021)64166128.
E-mail: byu@pub.sioc.ac.cn

唐于平, 俞飚^*, 胡杰, 吴弢, 惠永正. 虎眼万年青球茎中的化学成分[J]. .

Tang Yuping, Yu Biao^*, Hu Jie, Wu Tao, Hui Yongzheng . The Chemical Constituents from the Bulbs of Ornithogalum caudatum[J]. .

参考文献

[1] Liu DY, Wang KY, Zhang H, Chen WH and Chen ZL. [J] Chin Tradit Herb Drugs, 1998, 29: 443.
[2] Xu TH, Xu YJ, Liu DY and Xu DM. [J] Acta Pharm Sin, 2000, 35: 32.
[3] Tang YP, Yu B, Hu J, Wu T and Hui YZ. [J] J Nat Prod, to be published.
[4] Brennan JJ, Imondi AR, Westmoreland DG and Williamson MJ. [J] J Pharm Sci, 1982, 71: 1199.
[5] Rigo B, Lespagnol Ch and Pauly M. [J] J Hetercycl Chem, 1988, 25: 49.
[6] Tang YP, Lou FC and Wang JH. [J] Nat Prod Res Dev, 2001, 13: 5.
[7] Zheng WP, Tang YP, Lou FC and Zhi F. [J] J China Pharm Univ, 2000, 31: 5.
[8] Bai YL, Lou W and Liu YL. [J] Chin Tradit Herb Drugs, 1985, 16: 530.
[9] Lou FC, Wang GY and Guo YL. [J] J China Pharm Univ, 1998, 29: 316.
[10] Lin G, Xu XD, Liu D, Ju JH and Yang JS. [J] Chin Pharm J, 2000, 35: 298.
[11] Yang SC, Fang JM and Cheng YS. [J] J Chin Chem Soc (Taipei), 1995, 42: 573.
[12] Ikuta A and Itokawa H. [J] Phytochemistry, 1988, 27: 2813.
[13] Kamiya K, Yoshioka K, Saiki Y, Ikuta A and Satake T. [J] Phytochemistry, 1997, 44: 141.
[14] Sadtler Research Laboratories, Inc. Sadtler standard proton NMR Spectra [M], 1969, vol 7, 4407.
[15] Sadtler Research Laboratories, Inc. Sadtler standard proton NMR Spectra [M], 1969, vol 7, 4531.
[16] Zhou FX and Liang PY. [J] Chin Tradit Herb Drugs, 1980, 11: 523.
[17] Tang YP, Lou FC, Wang JH and Li YF. [J] Chin Pharm J, 2001, 36: 231.
[18] Tang YP, Wang JH, Li YF, Lou FC and Ma W. [J] Acta Phytoecol Geobot Sin, 2001, 10: 59.
[19] Coburn WC, Thorpe MC, Montgomery JA and Hewson. [J] J Org Chem, 1965, 30: 1114.
[20] Akhren AA, Mikhailopulo IA and Abranmov AF. [J] Org Magn Resonamce, 1979, 12: 247.
[21] Jares EA, Tettamanzi MC and Pomilio AB. [J] Phytochemistry, 1990, 29: 340.
[22] Lou FC, Ma QY and Du FL. [J] J China Pharm Univ, 1989, 20: 37.
[23] Tang YP, Wang Y, Lou FC, Li YF and Wang JH. [J] Acta Pharm Sin, 2000, 35: 363.
[24] Markham KR, Ternai B, Stanley R, Geiger H and Mabry TJ. [J] Tetrahedron, 1978, 34: 1389.