大黄酸: 一种新型潜在抗肿瘤药物

doi:10.5246/jcps.2016.05.036

中国药学(英文版) ›› 2016, Vol. 25 ›› Issue (5): 321-328.DOI: 10.5246/jcps.2016.05.036

• 【综述】 • 下一篇

大黄酸: 一种新型潜在抗肿瘤药物

俞璐¹, 姚国栋², 马卫成^1*

1. 宁波市泌尿肾病医院临床药学, 浙江宁波 315400
2. 沈阳药科大学中日医药研究所, 辽宁沈阳 110016

收稿日期:2016-01-15 修回日期:2016-02-22 出版日期:2016-05-30 发布日期:2016-02-26
通讯作者: Tel./Fax: +86-0574-55662548, E-mail: weichengma@126.com
作者简介:马卫成教授1991年毕业于浙江中医学院中药系, 1991年至2005年任职于宁波市鄞州人民医院药剂科, 先后任中药师(1991)、主管中药师(1998)、副主任中药师(2005)。2006年至今任职于宁波市泌尿肾病医院药剂科, 先后任副主任中药师(2006)、主任中药师(2010)。2012年至今任宁波大学医学院教授。2015年作为访问学者在美国伊利诺伊大学芝加哥分校进行学术交流。兼任浙江省药学会医院药学专业委员会委员、浙江省医学会临床药学分会青年委员会委员、浙江省中西医结合临床药学专业委员会委员、浙江省毒理学会临床药物治疗安全委员会委员; 并任《中国现代应用药学》杂志编委。主要从事医院药学及临床药学研究。主持参与各级科研项目10余项, 发表论文50余篇。

Rhein: a novel potential antitumor drug

Lu Yu¹, Guodong Yao², Weicheng Ma^1*

1. Department of Clinical pharmacy, Ningbo Urology and Nephrology hospital, Ningbo 315400, China
2. China-Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2016-01-15 Revised:2016-02-22 Online:2016-05-30 Published:2016-02-26
Contact: Tel./Fax: +86-0574-55662548, E-mail: weichengma@126.com
About author:Professor Ma graduated from Department of Traditional Chinese Medicine College of Zhejiang Chinese Medical University in 1991. From 1991 to 2005, he served in pharmacy department of Ningbo Yinzhou People’s Hospital as a herbalist (1991), charge herbalist (1998), deputy director herbalist (2005). From 2006 to now, he served in pharmacy department of Ningbo Urology and Nephrology Hospital as deputy director herbalist (2006), director herbalist (2010). He was also lectured in the School of Ningbo University as a professor. During that period, he went to University of Illinois Chicago Branch as a visiting scholar in 2015. Over these years, he has specialized in hospital pharmacy and clinical pharmacy and serves as member of the editorial board for professional publications. Professor Ma has published more than 50 associated papers in domestic and international journals.

摘要/Abstract

摘要：

大黄酸,化学结构式为1, 8-二羟基-3-羧基蒽醌,是富含于大黄根茎中的一种蒽醌类化合物,已经被证实具有抗炎与抗氧化的作用。最近研究发现,大黄酸可能还具有抗肿瘤的功能,然而其抗肿瘤的分子机制目前还未知。该综述主要概括分析了大黄酸研究的相关结果,以此推出大黄酸通过细胞周期阻滞、诱导细胞凋亡以及控制转移而发挥抗肿瘤作用。

关键词: 大黄酸, 肿瘤细胞, 凋亡, 细胞周期阻滞

Abstract:

Rhein (4,5-dihydroxyanthraquinone-2-carboxylic acid) is an anthraquinone compound enriched in the rhizome of rhubarb (Rheum palmatum or Rheum tanguticum Maxim), a traditional Chinese medicine herb. Natural product compounds are a source of novel therapeutic agents. Rhein has been initially identified as an anti-inflammatory and anti-oxidant agent. Recent studies indicate that rhein may also have an antitumor effect. However, the molecular mechanisms are still unclear. This review aims to summarize the research of rhein to better understand the anti-tumor activities by targeting cell cycle arrest, apoptosis, invasion, and metastasis of cancer cells. Meanwhile, we also intend to give an overview of the mechanisms identified so far. The breakthrough findings may shed light on using rhein as a targeted-cancer therapy.

Key words: Rhein, Cancer cells, Apoptosis, Cell cycle arrest

中图分类号:

R284

Supporting:

俞璐, 姚国栋, 马卫成. 大黄酸: 一种新型潜在抗肿瘤药物[J]. 中国药学(英文版), 2016, 25(5): 321-328.

Lu Yu, Guodong Yao, Weicheng Ma. Rhein: a novel potential antitumor drug[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(5): 321-328.

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大黄酸: 一种新型潜在抗肿瘤药物

Rhein: a novel potential antitumor drug

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