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中国药学(英文版) ›› 2015, Vol. 24 ›› Issue (3): 169-176.DOI: 10.5246/jcps.2015.03.021

• 【研究论文】 • 上一篇    下一篇

大叶钩藤茎三萜类成分研究

位玉仃1, 鄢连和2, 梁鸿1, 朱美晓2, 叶端炉3, 张庆英1*   

  1. 1. 北京大学医学部 天然药物及仿生药物国家重点实验室; 天然药物学系, 北京 100191
    2. 浙江省丽水市人民医院, 浙江 丽水 323000
    3. 浙江省庆元县人民医院, 浙江 丽水 323800
  • 收稿日期:2014-12-23 修回日期:2015-01-19 出版日期:2015-03-29 发布日期:2015-01-21
  • 通讯作者: Tel.: 86-10-82801725
  • 基金资助:
    Zhejiang Province Traditional Chinese Medicine Scientific Research Fund Project (Grant No. 2011 ZA115).

Triterpenoids from the stems of Uncaria macrophylla

Yuding Wei1, LianheYan2, Hong Liang1, Meixiao Zhu2, Duanlu Ye3, Qingying Zhang1*   

  1. 1. State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
    2. Lishui People’s Hospital, Lishui 323000, Zhejiang, China
    3. Qingyuan People’s Hospital, Lishui 323800, Zhejiang, China
  • Received:2014-12-23 Revised:2015-01-19 Online:2015-03-29 Published:2015-01-21
  • Contact: Tel.: 86-10-82801725
  • Supported by:
    Zhejiang Province Traditional Chinese Medicine Scientific Research Fund Project (Grant No. 2011 ZA115).

摘要:

从大叶钩藤茎中分离得到19个三萜类成分, 包括11个乌苏烷型三萜和8个齐墩果烷型三萜, 其化学结构通过波谱学方法鉴定。19个化合物中12个化合物为首次从大叶钩藤中分离得到, 6个化合物为首次从钩藤属植物中分离得到。

关键词: 大叶钩藤, 化学成分, 三萜

Abstract:

Nineteen triterpenoids, including eleven ursane triterpenoids and eight olenane triterpenoids, were isolated from the stems of Uncaria macrophylla Wall. by comprehensive chromatographic methods. Structure elucidation of the compounds was succeeded by extensive spectroscopic analysis. Twelve compounds were obtained from this plant for the first time, among which six compounds were obtained from the genus Uncaria for the first time.

Key words: Uncaria macrophylla, Chemical constituents, Triterpenoids

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