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复方止咳冲剂中甘草酸和绿原酸的高效液相色谱法测定

荣志芬, 薛会君, 张蔚青, 王欣宇, 邹安庆*   

  1. 1. 北京医科大学药学院, 北京 100083;
    2. 北京职工医学院药学系, 北京 100036
  • 收稿日期:1998-02-20 修回日期:1998-06-18 出版日期:1999-03-15 发布日期:1999-03-15
  • 通讯作者: 邹安庆*

Determination of Glycyrrhizic Acid and Chlorogcnic Acid in Compound Cough Granules by HPLC

Rong Zhifen, Xue Huijun, Zhang Weiqing, Wang Xinyu, Zou Anqing*   

  1. 1. College of Pharmacy, Beijing Medical University Beijing 100083
    2. Department of Pharmacy, Beijing Medical Staff Collese, Beijing 100036
  • Received:1998-02-20 Revised:1998-06-18 Online:1999-03-15 Published:1999-03-15
  • Contact: Zou Anqing*

摘要:

复方止咳冲剂由甘草、金银花等十几味中药与大量赋形剂制成。甘草酸与绿原酸是其中重要的化学组分。本文建立了同时测定甘草酸与绿原酸的RP-HPLC-UV方法。用C18不锈钢柱为色谱柱, 以甲醇(0.5%醋酸)-(0.5%醋酸)为流动相, 梯度法洗脱, 用外标法定量, 测定了三批样品.回收率均大于90%, 相对标准偏差均小于3%

关键词: HPLC, 甘草酸, 绿原酸, 冲剂

Key words: HPLC, Glycyrrhizic acid, Chlorogenic acid, Granules

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