Synthesis and antibacterial studies of ciprofloxacin-metal complexes

doi:10.5246/jcps.2019.06.041

中国药学(英文版) ›› 2019, Vol. 28 ›› Issue (6): 422-429.DOI: 10.5246/jcps.2019.06.041

Synthesis and antibacterial studies of ciprofloxacin-metal complexes

Najma Sultana¹, M. Saeed Arayne², Ahsan Zamir Siddiqi¹, Agha Zeeshan Mirza^3,4*

1. Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan
2. Department of Chemistry, University of Karachi
3. Chemistry Department, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia
4. Research Laboratories Centre, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia

收稿日期:2019-01-23 修回日期:2019-03-15 出版日期:2019-06-30 发布日期:2019-04-15
通讯作者: E-mail: azmirza@uqu.edu.sa

Synthesis and antibacterial studies of ciprofloxacin-metal complexes

Najma Sultana¹, M. Saeed Arayne², Ahsan Zamir Siddiqi¹, Agha Zeeshan Mirza^3,4*

1. Research Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan
2. Department of Chemistry, University of Karachi
3. Chemistry Department, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia
4. Research Laboratories Centre, Faculty of Applied Sciences, Umm Al-Qura University, Makkah, Saudi Arabia

Received:2019-01-23 Revised:2019-03-15 Online:2019-06-30 Published:2019-04-15
Contact: E-mail: azmirza@uqu.edu.sa

摘要/Abstract

摘要：

Metal complexes of ciprofloxacin were synthesized to study the effect of the drug on the metals present in the body or metals co-administered as multivitamin therapy. These complexes were then characterized by IR, UV, ¹H NMR, CHN and AA analyses. It was found that the metals coordinated through the β-keto carboxylic group, forming four coordinated complexes having square planar geometry. The effect of the antibacterial activity of these complexes with respect to parent drug was also studied against 14 different Gram+ve and Gram–ve organisms by the disk susceptibility technique. Some complexes showed improve activity as compared with the stated drug.

关键词: Ciprofloxacin, IR, UV, 1H NMR, CHN, AA analysis

Abstract:

Key words: Ciprofloxacin, IR, UV, 1H NMR, CHN, AA analysis

中图分类号:

R914

Supporting:

Najma Sultana, M. Saeed Arayne, Ahsan Zamir Siddiqi, Agha Zeeshan Mirza. Synthesis and antibacterial studies of ciprofloxacin-metal complexes[J]. 中国药学(英文版), 2019, 28(6): 422-429.

Najma Sultana, M. Saeed Arayne, Ahsan Zamir Siddiqi, Agha Zeeshan Mirza. Synthesis and antibacterial studies of ciprofloxacin-metal complexes[J]. Journal of Chinese Pharmaceutical Sciences, 2019, 28(6): 422-429.

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Synthesis and antibacterial studies of ciprofloxacin-metal complexes

Synthesis and antibacterial studies of ciprofloxacin-metal complexes

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