黄芪甲苷对心血管的保护作用

doi:10.5246/jcps.2013.03.031

黄芪甲苷对心血管的保护作用

刘帅, 张金国^*

山东省心脏疾病诊疗重点实验室济宁医学院附属医院心内二科, 山东济宁 272029

收稿日期:2012-08-25 修回日期:2013-01-05 出版日期:2013-05-08 发布日期:2013-05-08
通讯作者: 张金国*

Cardiovascular protective effects of astragaloside IV

Shuai Liu, Jinguo Zhang^*

The Second Department of Cardiology, Affiliated Hospital of Jining Medical College, Key Lab of Heart Disease Diagnose and Treatment in Shandong Province, Jining 272029, China

Received:2012-08-25 Revised:2013-01-05 Online:2013-05-08 Published:2013-05-08
Contact: Jinguo Zhang*

摘要/Abstract

摘要：

黄芪甲苷作为中药黄芪的主要有效成分, 具有舒张血管, 保护血管内皮细胞, 抗炎, 抗病毒, 正性肌力等多方面作用, 这些作用是通过抗氧化损伤、清除氧自由基、调节钙稳态、抗线粒体损伤等途径实现的。黄芪甲苷目前已有效用于治疗冠心病、心力衰竭、高血压、心肌炎等心血管疾病, 其对心血管的保护作用和机制有待进一步研究。

关键词: 黄芪甲苷, 心血管, 保护作用, 机制

Abstract:

Astragali Radix has been widely used in traditional Chinese medicine for centuries, especially for the treatment of cardiovascular diseases. Astragaloside IV (AST IV), one of the main active ingredients in Astragali Radix, is involved in various functions, including vasodilating effect, protecting the vascular endothelial cells, anti-inflammatory effect, antivirus effect, positive inotropism and so on. These functions are attributed to the ability of AST IV in scavenging oxygen free radicals, the regulation of calcium homeostasis, its anti-oxidative effect and prevention of mitochondrial damage. Astragaloside IV has been effectively used to treat coronary artery disease, heart failure, viral myocarditis, hypertension and other cardiovascular diseases. Its cardiovascular protective effects and mechanisms are worth studying.

Key words: Astragaloside IV, Cardiovascular, Protective effect, Mechanism

中图分类号:

Supporting: Foundation item: Shandong Provincial Natural Science Foundation (Grant No. ZR2011HL006).
^*Corresponding author. Tel.: 13181312256

刘帅, 张金国^*. 黄芪甲苷对心血管的保护作用[J]. , DOI: 10.5246/jcps.2013.03.031.

Shuai Liu, Jinguo Zhang^*. Cardiovascular protective effects of astragaloside IV [J]. , DOI: 10.5246/jcps.2013.03.031.

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