土槿皮的化学成分研究

doi:10.5246/jcps.2012.05.057

土槿皮的化学成分研究

蔡田芝, 齐文, 杨连梅, 涂光忠, 杨蓉, 谢可辉, 傅宏征^*

1. 北京大学医学部天然药物及仿生药物国家重点实验室, 北京 100191
2. 沈阳药科大学中药学院, 辽宁沈阳 110016
3. 扬州大学药学院, 江苏扬州 225009
4. 北京微量化学研究所, 北京 100091

收稿日期:2012-05-10 修回日期:2012-07-20 出版日期:2012-09-15 发布日期:2012-09-15
通讯作者: 傅宏征*

Chemical constituents of Pseudolarix kaempferi Gord

Tianzhi Cai, Wen Qi, Lianmei Yang, Guangzhong Tu, Rong Yang, Kehui Xie, Hongzheng Fu^*

1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China
2. College of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China
3. Department of Pharmaceutics, Yangzhou University, Yangzhou 225009, China
4. Beijing Institute of Microchemistry, Beijing 100091, China

Received:2012-05-10 Revised:2012-07-20 Online:2012-09-15 Published:2012-09-15
Contact: Hongzheng Fu*

摘要/Abstract

摘要： 对松科Pinaceae植物金钱松Pseudolarix kaempferi Gord的干燥根皮—土槿皮的化学成分进行了研究。应用硅胶, Sephadex LH-20, MCI柱色谱以及高效液相色谱等技术进行分离纯化, 利用化合物的理化常数和波谱数据鉴定其结构。分离并鉴定了26个化合物，分别为: 土槿丁酸 (1), 土槿甲酸 (2), 土槿乙酸 (3), 土槿丙酸 (4), 3β-乙酰氧基-齐墩果烷-11,13(18)二烯 (5), 3β-乙酰氧基-齐墩果烷-9(11), 12二烯 (6), 3β-羟基-齐墩果烷-11,13(18)二烯 (7), 3β-羟基-齐墩果烷-9(11),12二烯 (8), Celangulatin C (9), Celangulatin E (10), 17β-通关藤苷元B (11), 11α-O-(2-甲基丁酰基)-12β-O-乙酰基通关藤苷元B (12), 11α-O-(2-甲基丁酰基)-12β-O-巴豆酰基 (顺芷酰基)通关藤苷元B (13), β-谷甾醇酯 (14), 伞形花内酯 (15), 5,7-二羟基香豆素 (16), 花椒毒素 (17), 异虎耳草素 (18), 芒柄花黄素 (19), 毛蕊异黄酮 (20), Cnidimol B (21), 胸腺嘧啶 (22), 3-呋喃甲酸 (23), 2-呋喃甲酸 (24), 香草酸 (25), 原儿茶酸 (26)。其中化合物5–24为首次从该植物中分离得到; 并首次归属化合物1 的¹H和¹³C NMR谱数据。

关键词: 金钱松, 土槿皮, 化学成分

Abstract:

Phytochemical investigations of Pseudolarix kaempferi Gord led to the isolation of 26 known compounds. They were identified as follows: pseudolaric acid D (1), pseudolaric acid A (2), pseudolaric acid B (3), pseudolaric acid C (4), oleana-∆^11,13(18)-dien-3β-O-acetyl (5), oleana-∆^9(11),12-dien-3β-O-acetyl (6), oleana-∆^11,13(18)-dien-3β-hydroxyl (7), oleana-∆^9(11),12-dien-3β-hydroxyl (8), celangulatin C (9), celangulatin E (10), 17β-tenacigenin B (11), 11α-O-2-methyl butyryl-12β-O-acetyl tenacigenin B (12), 11α-O-2-methyl butyryl-12β-O-tigloyl tenacigenin B (13), β-sitosterol acetate (14), umbelliferone (15), 5,7-dihydroxyl coumarin (16), xanthotoxin (17), isopimpinellin (18), formononetin (19), calycosin (20), cnidimol B (21), thymine (22), 3-furoic acid (23), 2-furoic acid (24), vanillic acid (25), protocatechuic acid (26). Compounds 5–24 were isolated from P. kaempferi for the first time. And the ¹H and ¹³C NMR spectra of compound 1 were completely assigned for the first time.

Key words: Pseudolarix kaempferi Gord, Cortex Pseudolaricis, Chemical constituents

中图分类号:

R284

Supporting:

Foundation item: National Natural Science Foundation of China (Grant No. 30973628).
^*Corresponding author. Tel.: 86-10-82805212; Fax: 86-10-82802724

蔡田芝, 齐文, 杨连梅, 涂光忠, 杨蓉, 谢可辉, 傅宏征^*. 土槿皮的化学成分研究[J]. , DOI: 10.5246/jcps.2012.05.057.

Tianzhi Cai, Wen Qi, Lianmei Yang, Guangzhong Tu, Rong Yang, Kehui Xie, Hongzheng Fu^*. Chemical constituents of Pseudolarix kaempferi Gord [J]. , DOI: 10.5246/jcps.2012.05.057.

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