款冬花的化学成分

款冬花的化学成分

刘玉峰, 杨秀伟^*, 武滨

1. 北京大学药学院天然药物学系天然药物及仿生药物国家重点实验室, 北京 100083;
2. 山西省医药集团有限责任公司, 山西太原 030012

收稿日期:2007-07-19 修回日期:2007-11-10 出版日期:2007-12-15 发布日期:2007-12-15
通讯作者: 杨秀伟*

Chemical constituents of the flower buds of Tussilago farfara

Yu-Feng Liu, Xiu-Wei Yang^*, Bin Wu

1. Department of Natural Medicines and The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China;
2. Shanxi Medicine Group Co., Ltd., Taiyuan 030012, China

Received:2007-07-19 Revised:2007-11-10 Online:2007-12-15 Published:2007-12-15
Contact: Xiu-Wei Yang*

摘要/Abstract

摘要：

目的研究我国中药材规范化种植基地栽培的款冬花的化学成分, 为其质量评价提供科学依据。方法用色谱法分离, 并用各种谱学方法对化合物的结构进行鉴定。结果从款冬花中分离鉴定了28个化合物, 分别为:正二十七烷酸 (1)、邻苯二甲酸-双-2-乙基己酯 (2)、甲基丁酰-3,14-Z-去氢款冬素酯 (3)、甲基丁酰-3,14-E-去氢款冬素酯 (4)、款冬酮 (5)、邻苯二甲酸二丁酯 (6)、3β,16α-二羟基鲍尔烯 (7)、异鲍尔烯醇 (8)、豆甾醇 (9)、b-谷甾醇 (10)、2,2-二甲基-6-乙酰基苯骈二氢吡喃酮 (11)、正十六烷酸 (12)、7β-羟基谷甾醇 (13)、7α-羟基谷甾醇 (14)、7,14-bisdesacylnotonipetrone (15)、棕榈酸甘油酯 (16)、胡萝卜苷 (17)、6-羟基-2,6-二甲基庚-2-烯-4-酮 (18)、反式阿魏酸 (19)、异阿魏酸 (20)、反式咖啡酸 (21)、α-D-葡萄糖 (22)、蔗糖 (23)、邻苯二甲酸 (24)、对羟基苯甲酸 (25)、没食子酸 (26)、尿嘧啶核苷 (27)和腺嘌呤核苷 (28)。结论化合物1, 1216, 18 和 20为首次从本属植物中分离得到。

关键词: 菊科, 菊科, 菊科, 款冬花, 款冬花, 款冬花, 化学成分, 化学成分, 化学成分

Abstract:

Aim To study the chemical constituents of the flower buds of Tussilago farfara L. in the China National GAP Base of Traditional Chinese Materia Medica and provide scientific basis for quality control. Methods The constituents were separated and purified by different chromatographic methods, and their structures were elucidated by IR, MS and NMR techniques. Results Twenty eight compounds were isolated from the flower buds of T. farfara. Their structures were identified as n-heptacosane (1), bis(2-ethylhexyl)phthalate (2), 7-[3'-ethylcrotonoyloxy]-lα-[2'-methylbutyryloxy]-3,14-dehydro-Z-notonipetranone (3), 7-[3'-ethylcrotonoyloxy]-lα-[2'-methylbutyryloxy]-3,14-dehydro-E-notonipetranone (4), tussilagone (5), dibutyl phthalate (6), bauer-7-ene-3β,16α-diol (7), isobauerenol (8), stigmasterol (9), β-sitosterol (10), 2,2-dimethyl-6-acetylchromanone (11), n-hexadecanoic acid (12), 7β-hydroxysitosterol (13), 7α-hydroxysitosterol (14), 7,14-bisdesacylnotonipetrone (15), 2,3-dihydroxypropylpalmitate (16), daucosterol (17), 6-hydroxy-2,6-dimethylhept-2-en-4-one (18), ferulic acid (19), isoferulic acid (20), caffeic acid (21), α-D-glucose (22), sucrose (23), phthalic acid (24), p-hydroxybenzoic acid (25), gallic acid (26), uridine (27), and adenosine (28). Conclusion Compounds 1, 1216, 18 and 20 were obtained from the genus Tussilago for the first time.

Key words: Compositae, Compositae, Flower buds of Tussilago farfara L., Flower buds of Tussilago farfara L., Chemical constituents, Chemical constituents

中图分类号:

R284

Supporting: Foundation item: The National High-Tech ?63?Project (Grant No. 2004AA2Z3730-07) and State Projects of the Tenth-Five-year Plan (Grant No. 2001-BA701A62-11).
^*Corresponding author. Tel.: 86-10-82805106

刘玉峰, 杨秀伟^*, 武滨. 款冬花的化学成分[J]. .

Yu-Feng Liu, Xiu-Wei Yang^*, Bin Wu. Chemical constituents of the flower buds of Tussilago farfara[J]. .

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