基于细胞衰老角度结直肠癌治疗方法的进展: 中西药物的比较研究

doi:10.5246/jcps.2024.05.030

中国药学(英文版) ›› 2024, Vol. 33 ›› Issue (5): 396-411.DOI: 10.5246/jcps.2024.05.030

基于细胞衰老角度结直肠癌治疗方法的进展: 中西药物的比较研究

张涛¹, 刘皓辰¹, 赵亮², 张沂婧¹, 邓宇¹, 何永恒²^,^*()

^1. 湖南中医药大学研究生院, 湖南长沙 410208
^2. 湖南省中医药研究院附属医院, 湖南长沙 410006

收稿日期:2023-10-12 修回日期:2023-11-12 接受日期:2024-01-23 出版日期:2024-05-31 发布日期:2024-05-31
通讯作者: 何永恒

Advancements in cellular senescence-based therapeutic approaches for colorectal cancer: a comparative study of Chinese and western medications

Tao Zhang¹, Haochen Han¹, Liang Zhao², Yijing Zhang¹, Yu Deng¹, Yongheng He²^,^*()

¹ Graduate School, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China
² Department of Colorectal and Anorectal Surgery, the Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha 410006, Hunan, China

Received:2023-10-12 Revised:2023-11-12 Accepted:2024-01-23 Online:2024-05-31 Published:2024-05-31
Contact: Yongheng He
Supported by:
Hunan Provincial Natural Science Foundation Facial Project (Grant No. 2021JJ30419); Hunan Provincial Key Project of Chinese Medicine Research Program (Grant No. 2021017); Changsha Science and Technology Bureau Key Project (Grant No. kh2201062); Hunan University of Chinese Medicine Postgraduate Innovation Project (Grant No. 2022CX45); Health Commission of Hunan Province 2023 Health Appropriate Technology Promotion Program?(Grant No. 202319019186).

摘要/Abstract

摘要：

结直肠癌(Colorectal cancer, CRC)为临床高发的恶性肿瘤。本病由各种综合因素促成, 病因病机复杂, 至今尚未明确。细胞衰老是一种永久性的细胞周期终止状态, 抗肿瘤发生有力的保护机制, 在CRC发生中的发挥着至关重要的作用。CRC是一种发病率很高的恶性肿瘤, 病因复杂且不甚明了。细胞衰老的特点是不可逆的细胞分裂停滞, 它在CRC的发展过程中发挥着至关重要的作用, 是防止肿瘤形成的一种防御机制。目前临床上治疗CRC的方法, 如手术、放疗和化疗, 往往副作用大、费用高, 给患者带来巨大的生理和心理负担。因此, 探究副反应轻且疗效稳定的中医药疗法迫在眉睫。近年来, 大量相关研究表明中药单体及复方能调控癌细胞衰老而发挥抗癌的作用, 为临床上防治CRC提供了新思路。然而, 目前尚缺乏中医药调控细胞衰老防治CRC的系统综述。因此, 本文对近年来靶向调节细胞衰老以治疗CRC的西药化合物、中药单体及复方进行系统总结, 以期为CRC的治疗及药物研发提供新思路。

关键词: 细胞衰老, 结直肠癌, 中医药, 西药, 研究进展

Abstract:

Colorectal cancer (CRC) is a prevalent malignant neoplasm with complex and poorly understood etiology. Cellular senescence, characterized by irreversible cell division arrest, plays a crucial role in the development of CRC by acting as a defense mechanism against tumor formation. Current clinical treatment modalities for CRC, such as surgery, radiotherapy, and chemotherapy, often come with significant side effects and high costs, placing a substantial physical and psychological burden on patients. Consequently, exploring Chinese medicinal treatments with milder side effects and consistent efficacy is essential. Recent research has highlighted the potential of traditional Chinese medicine (TCM) components and formulations to modulate the senescence process of cancer cells and exhibit anticancer properties. These findings offer a promising avenue for the prevention and treatment of CRC within clinical settings. However, a comprehensive evaluation of how TCM can control cellular senescence to prevent and manage CRC is currently lacking. This article aims to provide a comprehensive overview of pharmaceutical compounds from western medicine, individual components of TCM, and their combinations in recent research that target cellular senescence as part of CRC treatment. The objective is to present new perspectives on CRC treatment and drug development.

Key words: Cellular senescence, Colorectal cancer, Traditional Chinese medicine, Western medicine, Research progress

Supporting:

张涛, 刘皓辰, 赵亮, 张沂婧, 邓宇, 何永恒. 基于细胞衰老角度结直肠癌治疗方法的进展: 中西药物的比较研究[J]. 中国药学(英文版), 2024, 33(5): 396-411.

Tao Zhang, Haochen Han, Liang Zhao, Yijing Zhang, Yu Deng, Yongheng He. Advancements in cellular senescence-based therapeutic approaches for colorectal cancer: a comparative study of Chinese and western medications[J]. Journal of Chinese Pharmaceutical Sciences, 2024, 33(5): 396-411.

图/表 2

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基于细胞衰老角度结直肠癌治疗方法的进展: 中西药物的比较研究

Advancements in cellular senescence-based therapeutic approaches for colorectal cancer: a comparative study of Chinese and western medications

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