水飞蓟素纳米传递系统的研究进展

doi:10.5246/jcps.2011.05.055

水飞蓟素纳米传递系统的研究进展

陈美婉, 谭雯, 王胜鹏, 钟章锋, 王一涛^*

澳门大学中华医药研究院中药质量研究国家重点实验室, 澳门 999078

收稿日期:2011-01-27 修回日期:2011-05-30 出版日期:2011-09-20 发布日期:2011-09-20
通讯作者: 王一涛*

Advances in the nanoparticle drug delivery systems of silymarin

Mei-Wan Chen, Wen Tan, Sheng-Peng Wang, Zhang-Feng Zhong, Yi-Tao Wang^*

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China

Received:2011-01-27 Revised:2011-05-30 Online:2011-09-20 Published:2011-09-20
Contact: Yi-Tao Wang*

摘要/Abstract

摘要： 纳米科学和纳米技术在纳米药物传递系统中具有很大的潜力。水飞蓟素纳米药物传递系统的研究和开发将改善其水溶性和脂溶性, 并提高生物利用度。固体脂质纳米粒、微乳、自微乳和脂质体等一系列水飞蓟素纳米处方的研究已越来越受到关注。本文综述了水飞蓟素纳米制剂的制备表征, 性能评价, 吸收、生物利用度等体内外研究, 为其制剂的进一步研究提供科学基础。

关键词: 纳米传递系统, 水飞蓟素, 研究进展

Abstract:

The recent advances in nanoscience and nanotechnology have greatly facilitated the development of nanoparticle drug delivery system. A nanoparticle drug delivery system of silymarin will improve its poor solubility in water and oil, thus enhancing its bioavailability. A variety of nanoparticle formulations of silymarin such as solid lipid nanoparticles, microemulsion and self-emulsifying drug delivery system, and liposomes have been extensively investigated. This paper reviews the advances of these formulations on their preparation and characterization, absorption and bioavailability, as well as in vivo and in vitro studies, in order to provide an assessment of current research for further pharmaceutical studies of silymarin.

Key words: Nanoparticle drug delivery system, Silymarin, Research advances

中图分类号:

R944

Supporting:

Foundation item: Research Fund of the University of Macau (Grant No. MYRG 208 (Y1-L4)-ICMS11-WYT).
^*Corresponding author. Tel.: 00853-83974691

陈美婉, 谭雯, 王胜鹏, 钟章锋, 王一涛^*. 水飞蓟素纳米传递系统的研究进展[J]. , DOI: 10.5246/jcps.2011.05.055.

Mei-Wan Chen, Wen Tan, Sheng-Peng Wang, Zhang-Feng Zhong, Yi-Tao Wang^* . Advances in the nanoparticle drug delivery systems of silymarin [J]. , DOI: 10.5246/jcps.2011.05.055.

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