红花岩黄芪药材的化学指纹分析

doi:10.5246/jcps.2015.10.083

中国药学(英文版) ›› 2015, Vol. 24 ›› Issue (10): 654-659.DOI: 10.5246/jcps.2015.10.083

红花岩黄芪药材的化学指纹分析

刘毅^1,2, 王伟^1,3, 赵玉英¹, 陈虎彪⁴, 梁鸿¹, 张庆英^1*

1. 北京大学医学部药学院天然药物及仿生药物国家重点实验室; 天然药物学系, 北京 100191
2. 中国食品药品检定研究院, 北京 100050
3. 清华大学生命科学院, 北京 100084
4. 香港浸会大学中药学院, 香港 999077

收稿日期:2015-05-25 修回日期:2015-07-18 出版日期:2015-10-21 发布日期:2015-08-20
通讯作者: Tel./Fax: 86-10-82801725, E-mail: qyzhang@hsc.pku.edu.cn
基金资助:
Quality Standards for Chinese Medicines of Chinese Pharmacopeia 2010 edition (Grant No. YZ-029) and National Natural Science Foundation of China (Grant No. 21372015).

Chemical analysis of the Hedysarum multijugum root by HPLC fingerprinting

Yi Liu^1,2, Wei Wang^1,3, Yuying Zhao¹, Hubiao Chen⁴, Hong Liang¹, Qingying Zhang^1*

1. State Key Laboratory of Natural and Biomimetic Drugs; Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China
2. National Institutes for Food and Drug Control, Beijing 100050, China
3. School of Life Sciences, Tsinghua University, Beijing 100084, China
4. School of Chinese Medicine, Hong Kong Baptist University, Hongkong 999077, China

Received:2015-05-25 Revised:2015-07-18 Online:2015-10-21 Published:2015-08-20
Contact: Tel./Fax: 86-10-82801725, E-mail: qyzhang@hsc.pku.edu.cn
Supported by:
Quality Standards for Chinese Medicines of Chinese Pharmacopeia 2010 edition (Grant No. YZ-029) and National Natural Science Foundation of China (Grant No. 21372015).

摘要/Abstract

摘要：

红花岩黄芪根在民间不仅作为一种草药入药, 同时在我国某些地区还作为药典品种红芪的代用品入药。本文首先建立了红花岩黄芪根的高效液相色谱指纹图谱分析方法, 并采用建立的方法对不同批次的红花岩黄芪根进行了化学指纹分析, 确定了22个共有指纹峰, 指认了其中8个特征指纹峰的化学结构。结果显示尽管不同产地红花岩黄芪根的化学指纹稍有差异, 但主要成分基本一致; 而红花岩黄芪根和红芪的化学指纹谱图则完全不同, 因此至少从化学角度表明红花岩黄芪根不宜作为红芪代用品入药。

关键词: 红花岩黄芪, 岩黄芪属, HPLC指纹图谱, 质量分析, 品种鉴别

Abstract:

The root of Hedysarum multijugum(RHM) is recorded as a folk herbal medicine in China and is sometimes used asa substitute for Hedysari Radix, which is a famous traditional Chinese medicine derived from the roots of Hedysarum polybotrys. In the present study, a sensible, reliable, and reproducible HPLC-DAD fingerprint analysis method for RHM was developed and then subsequently applied to analyze RHM samples from different origins. The chemical constituents of the RHM sampleswere generally consistent, although it wasslightly affected by the local environment of the plant. In addition, the chemical constituency of RHM was shown to be significantly different from that of Hedysari Radix, suggesting that RHM is not suitable as a substitute for Hedysari Radix, at least from the chemical point of view.

Key words: Hedysarum multijugum, Hedysarum, HPLC fingerprint, Quality analysis, Species identification

中图分类号:

R284

Supporting:

刘毅, 王伟, 赵玉英, 陈虎彪, 梁鸿, 张庆英. 红花岩黄芪药材的化学指纹分析[J]. 中国药学(英文版), 2015, 24(10): 654-659.

Yi Liu, Wei Wang, Yuying Zhao, Hubiao Chen, Hong Liang, Qingying Zhang. Chemical analysis of the Hedysarum multijugum root by HPLC fingerprinting[J]. Journal of Chinese Pharmaceutical Sciences, 2015, 24(10): 654-659.

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红花岩黄芪药材的化学指纹分析

Chemical analysis of the Hedysarum multijugum root by HPLC fingerprinting

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