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胀果甘草抗氧化活性成分的研究

邹坤, 赵玉英, 傅乃武, 乔梁, 张如意   

  1. 1.北京医科大学药学院, 北京 100083;
    2.中国医学科学院肿瘤研究所, 北京 100021
  • 收稿日期:1996-04-14 修回日期:1996-07-01 出版日期:1996-12-15 发布日期:1996-12-15

Antioxidant Constituents from G. inflata Bat Root

Kun Zou, Yu-Ying Zhao, Nai-Wu Fu, Liang Qiao, Ru-Yi Zhang   

  1. 1. School of Pharmaceutical Sciences; Beijing Medical University; Beijing 100083;
    2. Institution of Oncologr The Chinese Academy of Medical Sclences; Beijing100021
  • Received:1996-04-14 Revised:1996-07-01 Online:1996-12-15 Published:1996-12-15

摘要: 继前文工作, 又从胀果甘草根茎中获得了十七个化合物。其中五个鉴定为1: 蔗糖, 2: 4',5,7-三羟基-8-异戊烯-黄铜, 3: 甘草素, 4: 芒柄花素, 5: 光甘草酮。化合物1,4,5为首次从该植物中获得。在三个体外氧化体系中观察了它们的抗氧化活性。2,3,5显示出显著的清除O2.-的活性, 5H2O2诱导的溶血具有良好的抑制作用, 3, 5(HpD+Hν)诱导的溶血的抑制作用比某些典型的抗氧化剂都好。

关键词: 胀果甘草, 黄酮类, 光甘草酮, 抗氧化

Abstract: Continuing the previous report (1), seventeen compounds were isolated from the roots and rhizoma of Glycyrrhiza inflata Bat. On the basis of spectroscopic methods five of them were identified as sucrose (1), 4’,5,7-trihydroxy-8-prenyl-flavonc (2), liquiritigenin (3), formononetin (4), and glabrone (5) (1), (4) and (5) were obtained from this plant for the first time. Their antioxidant activities were observed in three oxidizing systems in vitro. (2), (3) and (5) showed remarkable activities in scavenging O2.- (5) exhibited good activity in inhibiting hemolysis induced by H2O2 (3) and (5) displayed higher inhibitory action on (HpD+hv)-induced hemolysis than som typical antioxidants.

Key words: Glycyrrhiza inflata, Flavonoids, Glabrone, Antioxidant

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