氢气的药理学作用及其给药途径的研究进展

doi:10.5246/jcps.2024.06.042

摘要/Abstract

摘要：

氢气是自然界中含量最丰富的元素, 是无色、无味、无臭的气体, 具有很强的还原性。目前的研究证实, 氢气具有抗氧化、抗疲劳、抗辐射、抗炎和降糖降脂的作用, 可以治疗各种缺血再灌注损伤、器官移植损伤、神经变性疾病、动脉粥样硬化和代谢综合征等多种疾病。氢气在水中的溶解度极低, 一个大气压下氢气的饱和浓度为只有0.8 ppm, 因此想要达到理想的氢气治疗浓度, 就必须提高氢气的含量和提供合适的给药途径。氢气的给药方式有吸入法给氢、饮用富氢水、饱和氢生理盐水注射、增加体内氢气产生和口服固体释氢药物等。本文总结了氢气的药理学作用及其给药途径, 为氢气在治疗应用上提供思路。

关键词: 氢气, 药理作用, 给药途径, 研究进展

Abstract:

Hydrogen, the simplest element in the universe. Hydrogen gas is colorless, odorless, and tasteless. As a reducing agent composed of two atoms. It exhibits strong reducing power and possesses numerous pharmacological effects, including anti-oxidation, antifatigue, anti-radiation, anti-inflammation, hypoglycemic, and hypolipidemic effects. Various methods exist for supplying hydrogen, but inhaling the gas is dangerous, drinking hydrogen-rich water is ineffective, and injecting hydrogen-rich saline is inconvenient. The most viable approach for clinical use is oral medicine, which produces hydrogen in vivo. Hydrogen gas holds promising potential as a clinical medicine in the future.

Key words: Hydrogen gas, Pharmacological effects, Administration route, Research progress

Supporting:

张慧, 张红梅, 彭军, 凌云. 氢气的药理学作用及其给药途径的研究进展[J]. 中国药学(英文版), 2024, 33(6): 571-578.

Hui Zhang, Hongmei Zhang, Jun Peng, Yun Ling. Advancements in pharmacological effects and administration routes of hydrogen gas: A comprehensive research overview[J]. Journal of Chinese Pharmaceutical Sciences, 2024, 33(6): 571-578.

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