http://jcps.bjmu.edu.cn

中国药学(英文版) ›› 2019, Vol. 28 ›› Issue (10): 699-703.DOI: 10.5246/jcps.2019.10.066

• 【研究论文】 • 上一篇    下一篇

木质素Secoisolariciresinol的高效合成

郭九州, 贾彦兴*   

  1. 北京大学药学院 天然药物及仿生药物国家重点实验室, 北京 100191
  • 收稿日期:2019-05-05 修回日期:2019-09-03 出版日期:2019-10-31 发布日期:2018-11-30
  • 通讯作者: Tel.: +86-10-82805166, E-mail: yxjia@bjmu.edu.cn
  • 基金资助:

    The Drug Innovation Major Project (Grant No. 2018ZX09711-001-005-005).

A concise total synthesis of secoisolariciresinol

Jiuzhou Guo, Yanxing Jia*   

  1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
  • Received:2019-05-05 Revised:2019-09-03 Online:2019-10-31 Published:2018-11-30
  • Contact: Tel.: +86-10-82805166, E-mail: yxjia@bjmu.edu.cn
  • Supported by:

    The Drug Innovation Major Project (Grant No. 2018ZX09711-001-005-005).

摘要:

本文报道了木质素(R,R)-Secoisolariciresinol的一种高效合成方法,该方法以二氢阿魏酸衍生物的仿生β-β’-自由基二聚为关键反应,仅以4步完成了天然产物的合成。Secoisolariciresinol向其他相关木脂素的转化研究正在进行中                     

关键词: Secoisolariciresinol, 木质素, 仿生合成, 全合成

Abstract:

A concise total synthesis of (R,R)-secoisolariciresinol was achieved in four steps, featuring a biomimetic β-β’ radical coupling of two dihydroferulic acid derivatives. The conversion of secoisolariciresinol to other related lignans was ongoing.

Key words: Secoisolariciresinol, Lignan, Total synthesis, Biomimetic synthesis

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