泽泻中倍半萜类化合物

doi:10.5246/jcps.2016.08.069

中国药学(英文版) ›› 2016, Vol. 25 ›› Issue (8): 614-620.DOI: 10.5246/jcps.2016.08.069

泽泻中倍半萜类化合物

于京艺, 王君, 梁鸿, 张庆英^*, 陈世忠, 屠鹏飞

北京大学医学部药学院天然药物及仿生药物国家重点实验室; 天然药物学系, 北京 100191

收稿日期:2016-05-24 修回日期:2016-06-15 出版日期:2016-09-01 发布日期:2016-06-20
通讯作者: Tel.: +86-010-82801725, E-mail: qyzhang@bjmu.edu.cn
基金资助:
The National Science and Technology Major Project of “Technological study on the safety and standards of Chinese materia medica” (Grant No. 2014ZX09304307-001-011) and Chinese materia medica supporting program of “Quality control base construction of Chinese material medica including Isatidis Radix, Carthami Flos, etc” by Ministry of Industry and Information Technology of Peoples Republic of China.

Sesquiterpenes from Alisma plantago-aquatica

Jingyi Yu, Jun Wang, Hong Liang, Qingying Zhang^*, Shizhong Chen, Pengfei Tu

State Key Laboratory of Natural and Biomimetic Drugs; Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2016-05-24 Revised:2016-06-15 Online:2016-09-01 Published:2016-06-20
Contact: Tel.: +86-010-82801725, E-mail: qyzhang@bjmu.edu.cn
Supported by:
The National Science and Technology Major Project of “Technological study on the safety and standards of Chinese materia medica” (Grant No. 2014ZX09304307-001-011) and Chinese materia medica supporting program of “Quality control base construction of Chinese material medica including Isatidis Radix, Carthami Flos, etc” by Ministry of Industry and Information Technology of Peoples Republic of China.

摘要/Abstract

摘要：

对泽泻中倍半萜类成分进行了研究, 从中共分离得到3个愈创木烷型(1-3)、1个刺参烷型(4)、1个苍耳烷型(5)和1个鼠尾草烷型(6)倍半萜, 其结构分别鉴定为泽泻薁醇氧化物(1), 泽泻薁醇(2), 东方泽泻醇(3), 刺参烷醇(4), 吉布洛萨软珊瑚二酮(5) 和7α,10α-环氧鼠尾草烷-10β-醇(6), 其中化合物6为新天然产物, 苍耳烷型和鼠尾草烷型倍半萜为首次从泽泻属植物中分离得到。另外对分离所得倍半萜类成分的生源途径进行了合理推测。

关键词: 泽泻, 倍半萜, 生源途径

Abstract:

Six sesquiterpenes, including three guaiane type sesquiterpenes (1–3), one oplopanone type sesquiterpene (4), one xanthane type sesquiterpene (5) and one salvialane type sesquiterpene (6), were isolated from Alisma plantago-aquatica for the first time. The structures of these six compounds were elucidated as alismoxide (1), alismol (2), orientalol B (3), oplopanone (4), gibberodione (5), and 7α,10α-epoxy-salvialan-10β-ol (6), respectively, among which 6 was a new natural product. Xanthane type and salvialane type sesquiterpenes were obtained from the genus Alisma for the first time. In addition, a plausible biosynthetic pathway for all isolates was discussed.

Key words: Alisma plantago-aquatica, Sesquiterpenes, Biogenetic pathway

中图分类号:

R284

Supporting:

于京艺, 王君, 梁鸿, 张庆英, 陈世忠, 屠鹏飞. 泽泻中倍半萜类化合物[J]. 中国药学(英文版), 2016, 25(8): 614-620.

Jingyi Yu, Jun Wang, Hong Liang, Qingying Zhang, Shizhong Chen, Pengfei Tu. Sesquiterpenes from Alisma plantago-aquatica[J]. Journal of Chinese Pharmaceutical Sciences, 2016, 25(8): 614-620.

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泽泻中倍半萜类化合物

Sesquiterpenes from Alisma plantago-aquatica

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