中药葛根的化学成分研究进展

doi:10.5246/jcps.2014.06.048

中国药学(英文版) ›› 2014, Vol. 23 ›› Issue (6): 347-360.DOI: 10.5246/jcps.2014.06.048

中药葛根的化学成分研究进展

宋玮, 李艳姣, 乔雪, 钱薏, 叶敏^*

北京大学医学部药学院天然药物及仿生药物国家重点实验室, 北京 100191

收稿日期:2014-04-06 修回日期:2014-04-24 出版日期:2014-06-28 发布日期:2014-05-05
通讯作者: Tel.: 86-10-82802024
作者简介:叶敏博士, 2000年毕业于北京中医药大学, 获学士、硕士学位; 2003年毕业于北京大学药学院, 获生药学专业博士学位; 2003–2007年先后于北京大学医学部、美国路易斯安娜州立大学、耶鲁大学医学院从事博士后研究; 2007年12月任北京大学药学院生药学专业副教授, 2012年9月始任教授。研究方向: 中药质量标准与代谢研究, 天然产物的生物转化研究。
基金资助:
National Natural Science Foundation of China (Grant No. 81222054), and the Program for New Century Excellent Talents in University from Chinese Ministry of Education (Grant No. NCET-11-0019).

Chemistry of the Chinese herbal medicine Puerariae Radix (Ge-Gen): A review

Wei Song, Yanjiao Li, Xue Qiao, Yi Qian, Min Ye^*

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

Received:2014-04-06 Revised:2014-04-24 Online:2014-06-28 Published:2014-05-05
Contact: Tel.: 86-10-82802024
About author:Dr. Ye graduated from Beijing University of Chinese Medicine in 2000 and obtained his B.Sc and M.Sc degrees. In 2003, he obtained his Ph.D. degree in Pharmacognosy from School of Pharmaceutical Sciences, Peking University. During 2003–2007, he did postdoctoral research at Peking University Health Science Center, Louisiana State University, and Yale University School of Medicine. In December 2007, he joined the School of Pharmaceutical Sciences at Peking University as an Associate Professor in Pharmacognosy and currently as a Professor. His research interest is quality control and DMPK of Chinese herbal medicines, and biotransformation of natural products.
Supported by:
National Natural Science Foundation of China (Grant No. 81222054), and the Program for New Century Excellent Talents in University from Chinese Ministry of Education (Grant No. NCET-11-0019).

摘要/Abstract

摘要：

葛根是一味常用中药, 来源于豆科葛属植物野葛Pueraria lobata (Willd.) Ohwi或甘葛藤Pueraria thomsonii Benth的干燥根。葛根具有多种显著的药理活性, 临床用于治疗高血压等心脑血管疾病、糖尿病等。本文对葛属植物的化学成分进行了综述, 主要包括黄酮、葛根苷、香豆素、三萜及三萜皂苷等类型。同时总结了近年来葛根药材定性定量分析的研究进展。

关键词: 葛根, 野葛, 甘葛藤, 化学成分, 成分分析

Abstract: Puerariae Radix (Ge-Gen in Chinese) is a popular traditional Chinese herbal medicine derived from the dried roots of Pueraria lobata (Willd.) Ohwi or P. thomsonii Benth. It shows significant pharmacological activities in the treatment of cardiovascular diseases, hypertension, and diabetes. This review summarizes progress in the chemistry study of Pueraria species, mainly covering the classes of flavonoids, puerosides, coumarins, triterpenoids, and triterpene saponins. Qualitative and quantitative chemical analyses are also covered.

Key words: Pueraria lobata, Pueraria thomsonii, Puerariae Radix, Chemical constituents, Chemical analysis

中图分类号:

R284

Supporting: National Natural Science Foundation of China (Grant No. 81222054), and the Program for New Century Excellent Talents in University from Chinese Ministry of Education (Grant No. NCET-11-0019).

宋玮, 李艳姣, 乔雪, 钱薏, 叶敏. 中药葛根的化学成分研究进展[J]. 中国药学(英文版), 2014, 23(6): 347-360.

Wei Song, Yanjiao Li, Xue Qiao, Yi Qian, Min Ye . Chemistry of the Chinese herbal medicine Puerariae Radix (Ge-Gen): A review[J]. Journal of Chinese Pharmaceutical Sciences, 2014, 23(6): 347-360.

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中药葛根的化学成分研究进展

Chemistry of the Chinese herbal medicine Puerariae Radix (Ge-Gen): A review

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